DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and SLC9A1

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_003038.2	Gene:	SLC9A1 / 6548	HGNCID:	11071	Length:	815	Species:	Homo sapiens

Alignment Length:	647	Identity:	182/647 - (28%)
Similarity:	303/647 - (46%)	Gaps:	101/647 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SNTTTTDNSSS---IHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDPPLIDSHAVEQ 96
            |.|.:|..||.   ..::.||....|  .|||. |...|.|.|..|...........||...|..
Human    40 SPTASTIRSSEPPRERSIGDVTTAPP--EVTPE-SRPVNHSVTDHGMKPRKAFPVLGIDYTHVRT 101

  Fly    97 EHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQNGSWKREEV 161
            ....||.: .:.|::.:|.    .::.|....:|||.:::.:|..:| .|....|:...:.:.:|
Human   102 PFEISLWI-LLACLMKIGF----HVIPTISSIVPESCLLIVVGLLVG-GLIKGVGETPPFLQSDV 160

  Fly   162 FSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGL--GEVAF 224
                 |||.||||||.::||.|....|.:|:|:||:||:.||..:|..:|..:|.:.|  ||...
Human   161 -----FFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQIN 220

  Fly   225 RLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNA 289
            .:...::..|||:||||||||.:|:|..:.::.:|::||||||:||||:::||.....:.||...
Human   221 NIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEH 285

  Fly   290 EASTGEAMFSALKTFCAMFFASAGIGVIFALISAL---LLKHIDLRKHPSLEFAMMLMFTYAPYV 351
            .....  :|....:|..:......:||::.:|:|.   ...||.:     :|...:.:::|..|:
Human   286 VGIVD--IFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRV-----IEPLFVFLYSYMAYL 343

  Fly   352 LAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQ 416
            .||..|||||||::..|:||..|...|:|..:..|::..::..:.::||.:|.:||::..:..|.
Human   344 SAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHH 408

  Fly   417 VELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDS 481
            ...:|||..::.|||.|...:..|.:.:||||..|:..|.|||:.:.||||||:::|...|
Human   409 WNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLL---- 469

  Fly   482 QEKRH-----VIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGR 541
             :|:|     :.:|..:.::.||..|.|.:..||:..|...||:..:   |:..||
Human   470 -DKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETK---RSINEE--------- 521

  Fly   542 KRSKSISLSKTREWGQAIDSEHLSE-LTEEEDVT----FTQARDRFGRMDRKY------------ 589
                             |.::.|.. ||..||:.    ....:|:..|.::||
Human   522 -----------------IHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSK 569

  Fly   590 ---FIPFFTRRFNSQELHECKS-------------QMADLTNKWYQAIRVSPLDSDESDEEI 635
               .|.|:.:....|.:...:|             .|.::..|...:.|:.|..|.:.:|||
Human   570 EPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEI 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	135/424 (32%)
SLC9A1	NP_003038.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..79		13/39 (33%)
		b_cpa1	95..660	CDD:273294	165/589 (28%)
		Na_H_Exchanger	105..503	CDD:279355	134/420 (32%)
		Interaction with TESC. /evidence=ECO:0000269\|PubMed:30287853	503..545		12/70 (17%)
		Interaction with CHP2. /evidence=ECO:0000269\|PubMed:21392185	515..545		9/58 (16%)
		NEXCaM_BD	602..700	CDD:293250	8/30 (27%)
		Interaction with CALM1. /evidence=ECO:0000269\|PubMed:30287853	633..815
		Interaction with TESC. /evidence=ECO:0000269\|PubMed:12809501	633..815
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810