Protein Alignment Nhe1 and slc9a5

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001106943.1
• Gene: slc9a5 / 565213
• ZFINID: ZDB-GENE-080225-43
• Length: 970
• Species: Danio rerio
• Alignment Length: 530
• Identity: 149/530 - (28%)
• Similarity: 256/530 - (48%)
• Gaps: 63/530 - (11%)

  Fly   111 IMLGILLIHSMLQTGFQY-------LPESIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMGFF 168
            |:...||:.|:.:..|.:       :|||.:::.||..:|..:.:     .|.|:.....|..||
Zfish    99 IIASWLLVASVAKILFHFSQRFTTAVPESCMLILLGLALGTVVLL-----ASKKQPYQLDPGLFF 158

  Fly   169 LVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIG---AGIYLLGLGEVAFRLSFSE 230
            |.|||.|:.::||.:....||.|:|:||::|:.||..:|...|   .|:.:.|:.:........|
Zfish   159 LFLLPTIVGDAGYFMPARLFFDNLGAILMYAVVGTLWNAFCTGFCLYGVKMAGVIDEKVDAGLME 223

  Fly   231 SFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNAEASTGE 295
            ...||:|||||||||.:|:|..:.|:..|.::|||||:||||:::||.........|........
Zfish   224 FLLFGALISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVYISFVEVGPGNVNTA 288

  Fly   296 AMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSG 360
            ..|..:.:|..:......:|:|||:|.|...:.  .:|...:|...:.:..|..|:.||...||.
Zfish   289 DYFKGIASFLIVSIGGTLVGLIFAVILAFFTRF--TKKVRIIEPMFIFLLVYLAYLTAELFSLSA 351

  Fly   361 IMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGL-AIFSFKHQVELSFVIW 424
            |:::.||||..:.|...|:|..::.|::.||:|||.||||.:|.:||: |:...|...:...|:.
Zfish   352 ILSLTFCGIGCNKYVEANISQKSRTTVKYTMKTLASIAETIIFIFLGISAVDKSKWAWDTGLVVS 416

  Fly   425 AIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVII 489
            .::..|:.||..:....:.:|.||...::...|.:|.:.|||||:::||.:.|:.:..:.:...:
Zfish   417 TLIFILVFRAMGVIGQTWFLNWFRLVPLDKIDQVVMSYGGLRGAVAFALVVLLDKEHVKAKDYFV 481

  Fly   490 TTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTRE 554
            .||:::|.||.:..|.:..||:|:||..:....:.:......|
Zfish   482 ATTIVVVFFTVMFQGLTIKPLVKWLKVPRSTNRKPTINEEIHE---------------------- 524

  Fly   555 WGQAIDSEHLSELTEEEDVT----FTQARDRFGRMDRKYFIPFFTRR--FNSQELHECKSQMADL 613
              :|.|  |:  |...||:.    :...||::.:.|:.|......|:  ::..||.|.
Zfish   525 --RAFD--HI--LAAVEDIAGLNGYHHWRDKWEQFDKNYLSKLLLRKSVYHKSELWEA------- 576

  Fly   614 TNKWYQAIRV 623
                ||.|.:
Zfish   577 ----YQKINI 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	129/414 (31%)
slc9a5	NP_001106943.1	b_cpa1	90..675	CDD:273294	149/530 (28%)
		Na_H_Exchanger	100..505	CDD:279355	127/411 (31%)
		NEXCaM_BD	645..>699	CDD:293250

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810