DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe1 and slc9a2

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001107567.1	Gene:	slc9a2 / 562904	ZFINID:	ZDB-GENE-070912-541	Length:	746	Species:	Danio rerio

Alignment Length:	420	Identity:	125/420 - (29%)
Similarity:	226/420 - (53%)	Gaps:	29/420 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LLIHSMLQTGFQ-------YLPESIVVVFLGAFIGLSLNVMSGQNGSWKREE---VFSPMGFFLV 170
            :|:.|..:.||.       ::|||.:::.||..:|..::.:        |:|   |.|...|||.
Zfish    34 VLLASFAKIGFNVYHKITVWVPESCLLISLGFVVGGVMHAV--------RKEPPAVISSNVFFLY 90

  Fly   171 LLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEV-AF---RLSFSES 231
            :|||||.||||.:....||:|:|:::.||:.||..:.:  |.||.|..:.:: ||   .::..|:
Zfish    91 MLPPIILESGYFMPTRPFFENVGTVMWFAVVGTLWNTM--GIGISLFAICQIEAFGVQDINLQEN 153

  Fly   232 FAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNAEASTGEA 296
            ..|.:::|||:|||.:::|..:.::..|.:::|||.:.|||:::||.......|.:  |......
Zfish   154 LLFAAILSAVEPVAVLSVFEDISINEQLYIVMFGECLFNDAVTVVLYNLFNHVAAM--EVDEPAV 216

  Fly   297 MFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGI 361
            :|..:..|..:.......|::|..::|...:...  |...:|..::.||:|..|::||...||.|
Zfish   217 IFMDIGGFFVVGLGGIFFGLLFGFLTAFTTRFTG--KVREIEPLVIFMFSYMSYLIAELFALSSI 279

  Fly   362 MAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFVIWAI 426
            ||||.|.:.|.:|...|:|..:..|::..::.:..::||.:|.:||:...:.:|:....::::.:
Zfish   280 MAILICTLSMKYYVEENVSQRSCTTIRHVIKMVGSVSETLIFFFLGVVSITTEHEWNWGYILFTL 344

  Fly   427 VLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITT 491
            ...|..|...|..|..::|.||:...|.:.||.:.:.|||||:|:||:..|. :|...|.:.||.
Zfish   345 FFTLFWRFLGILVLTQIINPFRKIPFNFQDQFGLAYGGLRGALSFALAFTLP-NSIPHRKLFITD 408

  Fly   492 TLIIVLFTTLVLGGSTMPLLKYLKPGKKRR 521
            |:.:::||..:.|.:..||||.:...|..|
Zfish   409 TIAVIIFTVFIQGITIRPLLKLMNIRKTNR 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	123/412 (30%)
slc9a2	NP_001107567.1	b_cpa1	21..578	CDD:273294	125/420 (30%)
		Na_H_Exchanger	30..429	CDD:279355	121/409 (30%)
		NEXCaM_BD	525..629	CDD:293250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810