Protein Alignment Nhe1 and slc9a6b

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001106947.1
• Gene: slc9a6b / 556638
• ZFINID: ZDB-GENE-080226-2
• Length: 692
• Species: Danio rerio
• Alignment Length: 617
• Identity: 191/617 - (30%)
• Similarity: 290/617 - (47%)
• Gaps: 120/617 - (19%)

  Fly    71 ASTTKRGNASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVV 135
            |..|:..|..|        :..|.|.....|.:|...|.::.:.||.|.......|::|.|:.:.
Zfish    31 AENTEMVNVVT--------ERKAEESHRQDSANLLIFITLLTITILTIWLFKHRRFRFLHETGLA 87

  Fly   136 VFLGAFIGLSLNV---------------------------MSGQ-------------------NG 154
            :..|.|:|:.|..                           :||:                   |.
Zfish    88 MIYGLFVGVILRFGVHSPQDTSEVTLSCAVNSSPTTILVNVSGRFYEYSLKGEVQDSKGHDVPNA 152

  Fly   155 SWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY---- 215
            ...|:..|.|..||.:|||||||.:||:|.:.:||:|:||||.:|..||..|..|.|..:|
Zfish   153 EMLRKVTFDPEVFFNILLPPIIFHAGYSLKRRHFFRNLGSILSYAFVGTMTSCFVTGLAMYSCVV 217

  Fly   216 -LLGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTA 279
             :..:|::.....|::...||:::||.|||..:|||:.|.||..|..|:||||:||||::|||::
Zfish   218 FMKIIGQLGGDFFFTDCLFFGAIVSATDPVTVLAIFNELKVDVDLYALMFGESVLNDAVAIVLSS 282

  Fly   280 SIT--QSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMM 342
            ||.  |....|.......|:...|..|..:|..|..:|....:::||:.|...||..|.||.|:.
Zfish   283 SIVAYQPEGDNRHTFDASALLKCLGVFLGVFSGSFAMGAATGVMTALVTKFTKLRDFPLLETALF 347

  Fly   343 LMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLG 407
            .:.:::.::|||....:|::|:|||||..:|||:.|||..::...:|....|.|:||..:|:|:|
Zfish   348 FLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESKSRTKQLFELLNFLAENFIFSYMG 412

  Fly   408 LAIFSFKHQV-ELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISY 471
            |.:|||:|.| ...|:|.|.|...:||..||:||:||:|..|::||.:..|.:|.|||||||:::
Zfish   413 LTLFSFQHHVFNPFFIIGAFVAIFLGRLANIYPLSFLLNLGRKNKIPSNFQHVMMFSGLRGAMTF 477

  Fly   472 ALSLHLNLDSQE-KRHVIITTTLIIVLFTTLVLGGSTMPLLK--YLKPGKKRRARGSGRNAAEEG 533
            |||:.   |:.. .|.::.:|||:||.||..|.||.|.|:|.  .::.|.......|...|
Zfish   478 ALSIR---DTATYARQMMFSTTLLIVFFTVWVCGGGTTPVLSLMQIRVGVDTEQDNSATAA---- 535

  Fly   534 GRRNGSGRKRSKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPFFT--- 595
               :|..::.:|..|....|.|                 .||          |..|..||.|
Zfish   536 ---DGMTQRSTKHESAWPFRLW-----------------YTF----------DHNYLKPFLTHSG 570

  Fly   596 ---------------RRFNSQELHECKSQMAD 612
                           |...|.:.:|...|:.|
Zfish   571 PPLTTTLPACCGPIARCLTSSQAYENAGQLHD 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	165/471 (35%)
slc9a6b	NP_001106947.1	Na_H_Exchanger	158..515	CDD:279355	147/359 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720