Protein Alignment Nhe1 and slc9a7

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001025248.2
• Gene: slc9a7 / 554532
• ZFINID: ZDB-GENE-050913-8
• Length: 718
• Species: Danio rerio
• Alignment Length: 642
• Identity: 201/642 - (31%)
• Similarity: 305/642 - (47%)
• Gaps: 124/642 - (19%)

  Fly    77 GNASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAF 141
            |....|.|:....:||     ...|::|...|.::.|.||.|........::|.|:.:.:..|..
Zfish    39 GGIEELATEKEAEESH-----RQDSVNLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLL 98

  Fly   142 IGLSL-----------------------------------------------NVMSGQNGSWKRE 159
            :|:.|                                               .:.|.:.....|:
Zfish    99 VGVILRYGIPSTSYHNKTPPSCMLKEGPVSTVLLNVSGKFFEYTLKGEINLREIHSVEQNDMLRK 163

  Fly   160 EVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-----LLGL 219
            ..|.|..||.:|||||||.:||:|.|.:||:|:|||:.:|..||.||..|||..:|     :..|
Zfish   164 LTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSIITYAFLGTAISCFVIGNLMYGVVKLMQVL 228

  Fly   220 GEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASIT-- 282
            |::..:..:::...||::|||.|||..:|||:.|..|..|..|:||||::|||:||||::||.
Zfish   229 GQLTDKFYYTDCLFFGAIISATDPVTVLAIFNELHADGDLYALLFGESVMNDAVSIVLSSSIVAY 293

  Fly   283 QSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTY 347
            |.:..|.......|.|.::..|..:|..|..:|.:..:::||:.|...|...|.||.|:..:.::
Zfish   294 QPSGANTHTFDASAFFKSVGVFIGIFSGSFAMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSW 358

  Fly   348 APYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFS 412
            :.::|||....:|::|:|||||..:|||:.|||..:....:|....|.|:||..:|:|:|||:|:
Zfish   359 STFLLAEACGFTGVVAVLFCGITQAHYTYNNLSEESTKRTKQLFEVLHFLAENFIFSYMGLALFT 423

  Fly   413 FK-HQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLH 476
            |: |.....|::.|.:...||||.||:||:||:|..|.|||....|.:|.|:|||||:::||::.
Zfish   424 FQNHVFSPIFIVGAFLAIFIGRALNIYPLSFLINLGRRHKIRGNFQHMMMFAGLRGAMAFALAIR 488

  Fly   477 LNLDSQE-KRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRAR-GSGRNAAEEGGRR--- 536
               |:.. .|.::.||||:||.||..|.||.|.|:|.:|      ..| |...:|.:|..||
Zfish   489 ---DTATYARQMMFTTTLLIVFFTVWVFGGGTTPMLSWL------HIRVGESSDAEKERMRRLWN 544

  Fly   537 ----------------------NGSGRKRSKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQAR 579
                                  .|.|   |:|...|||::     :|..|..|.    .||
Zfish   545 YDRVGVDPDQDLQPCGDSFQVLQGDG---SQSEGQSKTKQ-----ESAWLFRLW----YTF---- 593

  Fly   580 DRFGRMDRKYFIPFFTRRFN--SQELHECKSQMAD-LTNKWYQAIRV-SPLDSDESD 632
                  |..|..|..|....  :..|..|...:|. ||:.  ||... .||..::||
Zfish   594 ------DHNYLKPILTHSGPPLTSTLPACCGPLARCLTSP--QAYETHEPLRDNDSD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	162/470 (34%)
slc9a7	NP_001025248.2	Na_H_Exchanger	165..523	CDD:279355	148/360 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820