Protein Alignment Nhe1 and Nha2

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 115/546 - (21%)
• Similarity: 196/546 - (35%)
• Gaps: 158/546 - (28%)

  Fly    20 PESISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNAS---T 81
            ||..:|.:..|:..:...|.|..:.:..|..:|..|:           :||:|||...|.:   .
  Fly   160 PEDEAGADATQNAATIILTPTSLNLTNTTTQNVAANN-----------AGNSSTTTSTNTNYGPG 213

  Fly    82 LVTDPP-----------------LIDSHAVEQEHNSSLSLFFVICVIMLGILL------------ 117
            .|:..|                 .|.||.|......:|...|:....|..:||
  Fly   214 SVSGYPTPNATPGDEYKGPKWWLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMR 278

  Fly   118 ---------IHSMLQTGFQYLPESIVVVFLGA-FIGLSLNVMSGQNGSWKREEVF-SPMGFFLVL 171
                     |..:|.| |.:||:.:.::|.|. :..|.|....|    :::.|:| ..|....::
  Fly   279 IAFLFVGAQISGILVT-FVHLPDMLGMLFFGVLYANLGLANFEG----YQKFELFLREMALINIM 338

  Fly   172 LPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFSESFAFGS 236
            |     .:|..| .|:.|:.    |.|.|...|:...::.... :.||..:...:.:....|.|.
  Fly   339 L-----LAGLGL-DGDAFKR----LWFMILRLTLLPTIVEVAA-IAGLANLTLSMPWLWGIALGL 392

  Fly   237 LISAVDPVATVAIFHALDVDPI-----LNMLVFGESILNDAISIVL----------TASITQSAN 286
            :|:||.|...|.:...|..|.:     ::.|::..:..||.::|.:          |.|:||..
  Fly   393 VITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQV- 456

  Fly   287 VNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYA--- 348
              .:...|                 .|||::|..:...:|:::..|.           .|||
  Fly   457 --LQGPIG-----------------IGIGLVFGYLYGSMLQYLPSRN-----------ATYANGL 491

  Fly   349 PYVLAEGIHLSGIMAILFCGIVMSHYTHFN-LSTVTQITMQQTMRTLAFIA-------ETCVFAY 405
            .:||.   .|.|.:|::  |..:..||... |..|          |.||||       ||.:...
  Fly   492 RFVLT---ILGGTIAVM--GSRVIGYTSAGALGCV----------TTAFIARIGWRREETRLTPQ 541

  Fly   406 LGLA--IFSFKHQVELSFVIW----AIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSG 464
            ...|  |.|...:::|   :|    .:...|||:..|.       |..:.|.|......::..|.
  Fly   542 QLQAQQIASVPKRLDL---MWKFLKPVSFALIGKEINF-------NVLQGHVIGYGALLVLVGSL 596

  Fly   465 LRGAISYALSLHLNLDSQEKRHVIIT 490
            .|.|.:|..:...||..:|:.::.|:
  Fly   597 FRLAFAYLSTYGGNLSRKERAYITIS 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	94/446 (21%)
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	89/416 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900