Protein Alignment Nhe1 and Slc9a9

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001258367.1
• Gene: Slc9a9 / 363115
• RGDID: 1560736
• Length: 644
• Species: Rattus norvegicus
• Alignment Length: 560
• Identity: 189/560 - (33%)
• Similarity: 291/560 - (51%)
• Gaps: 96/560 - (17%)

  Fly    97 EHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSL--------------- 146
            :|..::.|.....:::|.||.|.......|::|.|:...:..|..:||.|
  Rat    17 QHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVY 81

  Fly   147 --------------------------------NVMSGQNGSWKREEVFSPMGFFLVLLPPIIFES 179
                                            |:...|..:...:..|.|..||.||||||||.:
  Rat    82 NCGKLLFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHA 146

  Fly   180 GYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-----LLGLGEV-AFRLSFSESFAFGSLI 238
            ||:|.|.:||||:||||.:|..||.||.:|||..:|     ::..|:: :....|::...||||:
  Rat   147 GYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLM 211

  Fly   239 SAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASIT-QSANVNAEASTGEAMFSALK 302
            ||.|||..:||||.|.|||.|..|:||||:||||::||||.||: .|...|..|....|.|.::.
  Rat   212 SATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVG 276

  Fly   303 TFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFC 367
            .|..:|..|..:|..:|:::|||.|...||:.|.||..:..:.:::.::.||...|:||:|:|||
  Rat   277 NFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFC 341

  Fly   368 GIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFK-HQVELSFVIWAIVLCLI 431
            |:..:|||:.|||:.:::..:|....:.|:||..:|.|:|||:|:|: |.....|::.|.:...:
  Rat   342 GVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFV 406

  Fly   432 GRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIV 496
            .|||||:||:||:|..|:.||....|.:|.||||||||::||::. |.:||.|: ::.||||::|
  Rat   407 ARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIR-NTESQPKQ-MMFTTTLLLV 469

  Fly   497 LFTTLVLGGSTMPLLKYL--KPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAI 559
            .||..|.||.|.|:|.:|  :.|..          .:|..:...|.::.:..:
  Rat   470 FFTVWVFGGGTTPMLTWLQIRVGVD----------LDESLKEEPSSQQEANKV------------ 512

  Fly   560 DSEHLSELTEEEDVTFTQARDRFGRM----DRKYFIPFFT 595
                      ::|:|.|::...| ||    |.||..|..|
  Rat   513 ----------DKDMTKTESAQLF-RMWYGFDHKYLKPILT 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	187/546 (34%)
Slc9a9	NP_001258367.1	Na_H_Exchanger	12..541	CDD:470090	188/558 (34%)