Protein Alignment Nhe1 and Nhe2

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 179/629 - (28%)
• Similarity: 297/629 - (47%)
• Gaps: 96/629 - (15%)

  Fly     9 AAALLL----------LVHAGPESISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNV-T 62
            |.||:|          .|...|..:| |::..:.|..|   ...|:.|..|......:|...| .
  Fly   101 ALALILGSAQARPNTSAVGVAPRKVS-QDIVDAVTQLN---LGQSAPIDAVDVGLDPTPSARVPR 161

  Fly    63 PSISASGNASTTKRGNASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGI-LLIHSMLQTGF 126
            |....||:.:.  :|:           :.|.:|:...||:....|....::|| :|..|:.:.||
  Fly   162 PEPLKSGDENA--KGD-----------EGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGF 213

  Fly   127 Q-------YLPESIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLH 184
            .       ..|||.:::.:|..||:.|...:....|     ..:|..||..:|||||.::||.:.
  Fly   214 HMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVS-----PLTPNTFFFYMLPPIILDAGYFMP 273

  Fly   185 KGNFFQNIGSILVFAIFGTTISALVIGAGIYLLG----LGEVAFRLSFSES------FAFGSLIS 239
            ...||.|:|:||:.|:.||..:...||..:|..|    .||       ||:      |.|.||||
  Fly   274 NRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGE-------SETPGLMDVFLFASLIS 331

  Fly   240 AVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMFSALKTF 304
            ||||||.:|:|..:.|:.||.::|||||:||||:::|:...:.....:..:....:.:.|.:.:|
  Fly   332 AVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSF 396

  Fly   305 CAMFFASAGIGVIFALISALLLKHIDLRKHPS-LEFAMMLMFTYAPYVLAEGIHLSGIMAILFCG 368
            ..:......||:|:..::.|:.:..|   |.. :|...:.:..|..|:.||..|:|||:||.|||
  Fly   397 FVVALGGTAIGIIWGFLTGLVTRFTD---HVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCG 458

  Fly   369 IVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFVIWAIVLCLIGR 433
            |.|.:|...|:|..:..|::..::.|:..|||.:|.:||:|..:..|.....||:..|..|.:.|
  Fly   459 ITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFR 523

  Fly   434 ACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLF 498
            ...:..|:.|.|:||.||::...||:|.:.|||||:::||.|.::.:..:::::.:|||:.::.|
  Fly   524 VIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYF 588

  Fly   499 TTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEH 563
            |..:.|.:..||:|.|   ..:||                  .||..:::        :.|....
  Fly   589 TVFLQGITIKPLVKIL---NVKRA------------------NKRKPTMN--------ERIHERF 624

  Fly   564 LSELTE--EEDVTFT---QARDRFGRMDRKYFIPFFTRRFNSQE 602
            :..|..  |:.|..|   ..||:|.|.|.::..|...|.....|
  Fly   625 MDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAE 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	140/433 (32%)
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	156/524 (30%)
		Na_H_Exchanger	199..602	CDD:279355	136/417 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468118
Domainoid	1	1.000	89	1.000	Domainoid score	I412
eggNOG	1	0.900	-	-		E1_COG0025
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51371
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840