Protein Alignment Nhe1 and Nha1

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_723224.2
• Gene: Nha1 / 33961
• FlyBaseID: FBgn0031865
• Length: 715
• Species: Drosophila melanogaster
• Alignment Length: 568
• Identity: 116/568 - (20%)
• Similarity: 195/568 - (34%)
• Gaps: 151/568 - (26%)

  Fly   107 VICVIMLGILLIHSMLQTGFQYLPES---------IVVVFLGA--------------FIGLSLNV 148
            :|.:|::|:|:    ..|.|..:.:|         :||:.:.|              .||:.|..
  Fly   225 LISIILIGVLI----WVTAFVIIGDSAAPGGQLFGLVVLTVAANFGGYLISLTTLPRLIGMLLVG 285

  Fly   149 MSGQNGSWKR-EEVFSPMGFFL--VLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVI 210
            :..||..|.. :..||.:...|  ..|..|:..:|..:....|.:...:||...|....:.|:|:
  Fly   286 ILFQNVGWADIDGDFSKVTAHLRKFALTIILTRAGLEMEPEAFKKVYKTILKLGIIPWCVEAVVM 350

  Fly   211 GAGIYLLGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVD--------PILNMLVFGES 267
            ....:.|      ..|.:..:|..||:|:||.|...|.....|...        |.|.:.|.|
  Fly   351 AVMSHFL------LDLPWIWAFLLGSIIAAVSPAVVVPCLFRLRTKGYGVAKGIPTLVVAVAG-- 407

  Fly   268 ILNDAISIVLTASITQSANVNAEASTGEAMFS--------ALKTFCAMFFASAGIGVIFALISAL 324
             ::||:|:.:...|:            ..|||        |....|.:  ...|.||::..::.:
  Fly   408 -VDDALSVAIFGIIS------------TVMFSDKGLAYQIAQAPVCIL--GGLGFGVVWGSLARI 457

  Fly   325 LLKHIDLRKHPSLEFAMMLMFT---YAPYVLAE-GIHLSGIMAILFCGIVMSHYTHFNLSTVTQI 385
            ..:..|....|   ...:|:||   .|.|...| |...:|.:|::|...|.:.:...:...|...
  Fly   458 FPEKGDAYVVP---LRTLLLFTGGLMAIYGSEELGFEGAGPLAVVFSAFVSNLFWCKDGWDVEDN 519

  Fly   386 TMQQTMRTLAFIAETCVFAYLGLAIFSFK---HQVELSFVIWAIVLCLIGRACNIFP-------- 439
            .:.........|.|..:|...|..|...:   |.|.            ||.|| ||.
  Fly   520 PVSTAFEIFWMIFEPILFGLTGATIKIRELDSHTVS------------IGAAC-IFTGAILRILT 571

  Fly   440 ---LAFLVNKFREHKINNKMQFIMWFSGL-RGAISYALS----LHLNLDSQEKRH---VIITTTL 493
               :||      ..::|.|.:|.:..|.: :..:..||.    .||..|:.|:..   .|:.|..
  Fly   572 TAGIAF------GDRLNTKEKFFVGLSWMAKATVQAALGPVALKHLGDDATEEERNWANIVQTIC 630

  Fly   494 IIVLFTTLVLGG------STMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKT 552
            :..:..|..||.      .|..|.|..:|                   ::.||.:||...|:.
  Fly   631 VFSIVLTAPLGAIMISVTGTKLLTKTKQP-------------------QDLSGWRRSHRPSIR-- 674

  Fly   553 REWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPFFTRRFNS 600
                   |...:.|..|.||....:.::..........||..:..:|:
  Fly   675 -------DISIIDEEEEREDPEIPEDKETHDNTLNNAHIPSISYTYNT 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	114/559 (20%)
Nha1	NP_723224.2	NhaP	253..>661	CDD:439796	96/471 (20%)