DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a9

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_808577.3	Gene:	Slc9a9 / 331004	MGIID:	2679732	Length:	644	Species:	Mus musculus

Alignment Length:	568	Identity:	188/568 - (33%)
Similarity:	285/568 - (50%)	Gaps:	112/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSL--------------- 146
            :|..::.|.....:::|.||.|.......|::|.|:...:..|..:||.|
Mouse    17 QHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVY 81

  Fly   147 --------------------------------NVMSGQNGSWKREEVFSPMGFFLVLLPPIIFES 179
                                            |:...|..:...:..|.|..||.||||||||.:
Mouse    82 NCGNLFFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHA 146

  Fly   180 GYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-----LLGLGEV-AFRLSFSESFAFGSLI 238
            ||:|.|.:||||:||||.:|..||.||.:|||..:|     ::..|:: :....|::...||||:
Mouse   147 GYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLM 211

  Fly   239 SAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASIT-QSANVNAEASTGEAMFSALK 302
            ||.|||..:||||.|.|||.|..|:||||:||||::||||.||: .|...|..|....|.|.::.
Mouse   212 SATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVG 276

  Fly   303 TFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFC 367
            .|..:|..|..:|..:|:::|||.|...||:.|.||..:..:.:::.::.||...|:||:|:|||
Mouse   277 NFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFC 341

  Fly   368 GIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFK-HQVELSFVIWAIVLCLI 431
            |:..:|||:.|||:.:::..:|....:.|:||..:|.|:|||:|:|: |.....|::.|.:...:
Mouse   342 GVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFV 406

  Fly   432 GRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIV 496
            .|||||:||:||:|..|:.||....|.:|.||||||||::||::. |.:||.|: ::.||||::|
Mouse   407 ARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIR-NTESQPKQ-MMFTTTLLLV 469

  Fly   497 LFTTLVLGGSTMPLLKYL--------------KPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSI 547
            .||..|.||.|.|:|.:|              :|..::.|              |...:..:|:.
Mouse   470 FFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEA--------------NKLDKNMTKTE 520

  Fly   548 SLSKTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPFFT 595
            |....|.|                          :| .|.||..|..|
Mouse   521 SAQLFRMW--------------------------YG-FDHKYLKPILT 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	174/483 (36%)
Slc9a9	NP_808577.3	Na_H_Exchanger	128..486	CDD:279355	159/359 (44%)
Slc9a9	NP_808577.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..644
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720