Protein Alignment Nhe1 and Slc9a8

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001020452.2
• Gene: Slc9a8 / 311651
• RGDID: 1308193
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 332/613 - (54%)
• Similarity: 416/613 - (67%)
• Gaps: 56/613 - (9%)

  Fly    35 SNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDPPL-------IDSH 92
            ||||....:.::||...|                    |||      ||...|.       ....
  Rat     6 SNTTHESFNFTLHTTLGV--------------------TTK------LVLPTPAKPILPVQTGEQ 44

  Fly    93 AVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQN-GSW 156
            |.::|.:|.:::||.:.|:.:.|:|:|.:::....:||||:.||.||..:|..:.|:..:. .:|
  Rat    45 AQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANW 109

  Fly   157 KREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGE 221
            |.||:|.|..|||:|||||||||||:|||||||||||||.:||:|||.|||.|:|.|||.||..:
  Rat   110 KEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD 174

  Fly   222 VAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSAN 286
            |..:|:.::||||||||||||||||:|||:||.|||:||||||||||||||:|||||.:......
  Rat   175 VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTR 239

  Fly   287 VNAEASTGEAMFS-ALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPY 350
            .:....:|...|| ||..|..|||.||.:|.:..|||||:||||||||.|||||.||::|.|.||
  Rat   240 KHMSDVSGWQTFSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPY 304

  Fly   351 VLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKH 415
            .|||||.|||||||||.|||||||||.|||.||||.||||:||:||:.||||||:|||:||||.|
  Rat   305 GLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPH 369

  Fly   416 QVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLD 480
            :.|:|||||.|||.|.|||.|||||::|:|.||:|||..||.||||||||||||.|||||||.|:
  Rat   370 KFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLE 434

  Fly   481 SQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSK 545
            ..|||.:|.|||:||||||.|:||||||||:: |...:..|||                 |:..|
  Rat   435 PMEKRQLIGTTTIIIVLFTILLLGGSTMPLIR-LVDIEDARAR-----------------RRSKK 481

  Fly   546 SISLSKTREWGQAIDSEHLSELTEEE-DVTFTQARDRFGRM--DRKYFIPFFTRRFNSQELHECK 607
            .::||||.:.|.||:||||||||||| :..:.:.:|..|.|  |.||..||||||...::||..:
  Rat   482 DVNLSKTEKMGNAIESEHLSELTEEEYEAHYIRQQDLKGFMWLDAKYLNPFFTRRLTQEDLHHGR 546

  Fly   608 SQMADLTNKWYQAIRVSPLDSDESDEEI 635
            .||..||||||:.:|..|..|::.::|:
  Rat   547 IQMKSLTNKWYEEVRQGPSGSEDDEQEL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	297/490 (61%)
Slc9a8	NP_001020452.2	Na_H_Exchanger	58..>482	CDD:470090	270/441 (61%)