DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and SLC9A9

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_775924.1	Gene:	SLC9A9 / 285195	HGNCID:	20653	Length:	645	Species:	Homo sapiens

Alignment Length:	532	Identity:	189/532 - (35%)
Similarity:	288/532 - (54%)	Gaps:	69/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSG----QNGS-- 155
            :|..::.|.....:::|.||.|.......|::|.|:...:..|..:||.|...:.    ::|:
Human    17 QHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVY 81

  Fly   156 ------------------------WKRE-----------------EVFSPMGFFLVLLPPIIFES 179
                                    :|||                 ..|.|..||.||||||||.:
Human    82 DCVKLTFSPSTLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHA 146

  Fly   180 GYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-----LLGLGEVA---FRLSFSESFAFGS 236
            ||:|.|.:||||:||||.:|..||.||.:|||..:|     ::..|::.   |.  |::...|||
Human   147 GYSLKKRHFFQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFH--FTDCLFFGS 209

  Fly   237 LISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASIT-QSANVNAEASTGEAMFSA 300
            |:||.|||..:||||.|.|||.|..|:||||:||||::||||.||: .|...|..|....|.|.:
Human   210 LMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDAAAFFQS 274

  Fly   301 LKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAIL 365
            :..|..:|..|..:|..:|:|:|||.|...|.:.|.||..:..:.:::.::.||...|:||:|:|
Human   275 VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVL 339

  Fly   366 FCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFK-HQVELSFVIWAIVLC 429
            |||:..:|||:.|||:.::|..:|....:.|:||..:|.|:|||:|:|: |.....|::.|.:..
Human   340 FCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAI 404

  Fly   430 LIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLI 494
            .:.|||||:||:||:|..|:.||....|.:|.||||||||::||::. |.:||.|: ::.||||:
Human   405 FVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIR-NTESQPKQ-MMFTTTLL 467

  Fly   495 IVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRR----NGSGRKRSKSISLSKTREW 555
            :|.||..|.||.|.|:|.:|   :.|.......|..|:...:    |...:..:|:.|....|.|
Human   468 LVFFTVWVFGGGTTPMLTWL---QIRVGVDLDENLKEDPSSQHQEANNLDKNMTKAESARLFRMW 529

  Fly   556 GQAIDSEHLSEL 567
             .:.|.::|..:
Human   530 -YSFDHKYLKPI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	177/471 (38%)
SLC9A9	NP_775924.1	Na_H_Exchanger	128..486	CDD:279355	161/361 (45%)
SLC9A9	NP_775924.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720