Protein Alignment Nhe1 and Slc9a5

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_006531127.1
• Gene: Slc9a5 / 277973
• MGIID: 2685542
• Length: 971
• Species: Mus musculus
• Alignment Length: 647
• Identity: 172/647 - (26%)
• Similarity: 283/647 - (43%)
• Gaps: 149/647 - (23%)

  Fly    63 PSISASGNASTTKRGNASTLVTDPP------LIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSM 121
            |.:..:|..:|.:....|..:.:||      ....|.||..:..:|    .|.|..|..::.| :
Mouse    10 PGLPLAGAGATEEPTQESGPLGEPPPGLALFRWQWHEVEAPYLVAL----WILVASLAKIVFH-L 69

  Fly   122 LQTGFQYLPESIVVVFLGAFI-GLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHK 185
            .:.....:|||.:::.||..: |:.|.|..      |.|....|..|||.|||||:.:|||.:..
Mouse    70 SRKVTSLVPESCLLILLGLVLGGIVLAVAK------KAEYQLEPGTFFLFLLPPIVLDSGYFMPS 128

  Fly   186 GNFFQNIGSILVFAIFGTTISALVIGAGIY-LLGLGEVAFRL--SFSESFAFGSLISAVDPVATV 247
            ..||.|:|:||.:|:.||..:|...|..:: |...|.||.|:  ...:...||||||||||||.:
Mouse   129 RLFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVL 193

  Fly   248 AIFHALDVDPILNMLVFGESILNDAISIVL---TASITQSANVNAEASTGEAMFSALKTFCAMFF 309
            |:|..:.|:..|.:::||||:||||:::||   ..|..:..:.|.:|:      ..||...::|.
Mouse   194 AVFEEVHVNQTLFIIIFGESLLNDAVTVVLYKVCNSFVEMGSANVQAT------DYLKGVASLFV 252

  Fly   310 ASAG---IGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVM 371
            .|.|   :|::||.:.||..:.  .::...:|..::.:..||.|:.||...||.|:|:..||:..
Mouse   253 VSLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGC 315

  Fly   372 SHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGL-AIFSFKHQVE-------LSFVIWAIVL 428
            ..|...|:|..::..::.||:|||..|||.:|..||: |:.|.|...:       |.|:::...|
Mouse   316 KKYVEANISHKSRTAVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRAL 380

  Fly   429 CLIGRAC-------------------------------------------------------NIF 438
            .:.|..|                                                       ::.
Mouse   381 GIAGALCSPVPFLSPLAAPHPLSPSSHPHQFPCLPAALTCPDPCQTLAQMLGAGLPVSSTPNSLL 445

  Fly   439 PLA-----------FLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTT 492
            |||           :.:|:||...::...|.:|.:.|||||:::||.:.|:......:...:.||
Mouse   446 PLALPPAVGVVLQTWALNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATT 510

  Fly   493 LIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQ 557
            :::|.||.:|.|.:..||:|:|:.                         |||.....:..:|.
Mouse   511 IVVVFFTVIVQGLTIKPLVKWLRV-------------------------KRSDYHKPTLNQEL-- 548

  Fly   558 AIDSEHLSE--LTEEEDVT----FTQARDRFGRMDRKYFIPFFTRRFNSQELHECKSQMADL 613
               .||..:  |...|||.    :...|||:.:.|:||......||    ..:..:.|:.|:
Mouse   549 ---HEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRR----SAYRIRDQIWDV 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	142/498 (29%)
Slc9a5	XP_006531127.1	b_cpa1	44..706	CDD:273294	166/613 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810