Protein Alignment Nhe1 and Slc9a4

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_006244800.1
• Gene: Slc9a4 / 24785
• RGDID: 3721
• Length: 797
• Species: Rattus norvegicus
• Alignment Length: 641
• Identity: 185/641 - (28%)
• Similarity: 301/641 - (46%)
• Gaps: 130/641 - (20%)

  Fly    38 TTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDPPLIDSHAVEQEHNSSL 102
            |..:.||.::..|     ||.|..||....:.::|            ||         .|..|..
  Rat    22 TCLEASSYVNESS-----SPTGQQTPDARFAASSS------------DP---------DERISVF 60

  Fly   103 SLFFVICVIMLGI---LLIHSMLQTGF-------QYLPESIVVVFLGAFIGLSLNVMSGQNGSWK 157
            .|.:....|...:   :|:.|:.:.||       ..:|||.:::.:||.:|   :::.|.:  .|
  Rat    61 ELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVG---SIIFGTH--HK 120

  Fly   158 REEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLL----- 217
            ...|.....:||.|||||:.||||.:....||:||||||.:|..|..|:|..||..:|.:
  Rat   121 SPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKA 185

  Fly   218 -GLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASI 281
             |||::    :..::..||||||||||||.:|:|....|:..|.|::|||::|||.||:||...:
  Rat   186 FGLGDI----NLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNIL 246

  Fly   282 TQSANVNAEASTGEAMFSALKTF-----CAMF--FASAGI--GVIFALISALLLKHIDLRKHPSL 337
            .        |.|....|..::..     ||.|  ....|:  |:||..|||.:.:.  .:...::
  Rat   247 I--------AFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRF--TQNISAI 301

  Fly   338 EFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCV 402
            |..::.||:|..|:.||.::||||:||..|.:.|..|...|:|..:..|::..|:.|:.::||.:
  Rat   302 EPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLI 366

  Fly   403 FAYLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRG 467
            |.::|::.....|:...:||.:.:..|.|.||.::|.|.::.|:||....:.|.|.|:::||:||
  Rat   367 FIFMGVSTVGKNHEWNWAFVCFTLAFCQIWRAISVFTLFYVSNQFRTFPFSIKDQLIIFYSGVRG 431

  Fly   468 AISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEE 532
            |.|::|:..|.|....::.:.:|.||::..||....|.:..||::||
  Rat   432 AGSFSLAFLLPLSLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYL------------------ 478

  Fly   533 GGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSELTEE-----EDV----TFTQARDRFGRMDRK 588
                  ..||.:|.          ::|:.|....|.:.     |||    :..|.||:|.:.|.:
  Rat   479 ------DVRKTNKK----------ESINEELHIRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHR 527

  Fly   589 YFIPFFTRRFNSQELHECKSQMADLTNK--WYQAIRVSPLDSDESDEEIGLAASTS 642
            |......||      ::.||.:..|..|  ..|||.::         |.||.:|.:
  Rat   528 YLRKILIRR------NQPKSSIVSLYKKLEMKQAIEMA---------ETGLLSSVA 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	143/439 (33%)
Slc9a4	XP_006244800.1	b_cpa1	63..621	CDD:273294	170/574 (30%)
		Na_H_Exchanger	73..476	CDD:279355	139/421 (33%)
		NEXCaM_BD	569..675	CDD:293250	185/641 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810