DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a3

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_038956774.1	Gene:	Slc9a3 / 24784	RGDID:	3720	Length:	864	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	173/606 - (28%)
Similarity:	294/606 - (48%)	Gaps:	121/606 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 VEQEHNSSLSLFFVI---------CVIMLGILLIHSMLQTGF-------QYLPESIVVVFLGAFI 142
            :|:|.||..|...|.         .:|.|.| |:.|:.:..|       ..:|||.:::.||..:
  Rat    29 IEEEPNSGGSFQIVTFKWHHVQDPYIIALWI-LVASLAKIVFHLSHKVTSVVPESALLIVLGLVL 92

  Fly   143 GLSLNVMSGQNGSWKREEVFS----PMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGT 203
            |..:         |..:.:.|    |..||..|||||:.::||.:....||.|:|:||::|:.||
  Rat    93 GGIV---------WAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGT 148

  Fly   204 TISALVIGA---GIYLLGL-GEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVF 264
            ..:|...|.   |::|.|| ||:  ::...:...|||||:||||||.:|:|..:.|:.:|.::||
  Rat   149 IWNAATTGLSLYGVFLSGLMGEL--KIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVF 211

  Fly   265 GESILNDAISIVLTASITQSANVNAEASTGEAMFSALKTFCAMFFASAG---IGVIFALISALL- 325
            |||:||||:::||.........:..:|.||   ...:|...:.|..|.|   :|||||.:.:|:
  Rat   212 GESLLNDAVTVVLYNVFESFVTLGGDAVTG---VDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVT 273

  Fly   326 --LKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQ 388
              .||:.:     :|...:.:.:|..|:.:|.:.||.|:||.||||....|...|:|..:..|::
  Rat   274 RFTKHVRI-----IEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVR 333

  Fly   389 QTMRTLAFIAETCVFAYLGLA-----IFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFR 448
            .||:.||..|||.:|.:||::     |:::    ..:||:..:|...:.||..:....:::|::|
  Rat   334 YTMKMLASGAETIIFMFLGISAVDPVIWTW----NTAFVLLTLVFISVYRAIGVVLQTWILNRYR 394

  Fly   449 EHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKY 513
            ..::....|.:|.:.|||||::|||.:.|:....:::::.::||||:|.||.:..|.:..||:::
  Rat   395 MVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQW 459

  Fly   514 LKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTRE-------WGQAIDSEHLSELTEEE 571
            ||                               :..|:.||       .|:|.|  |:  |:..|
  Rat   460 LK-------------------------------VKRSEQREPKLNEKLHGRAFD--HI--LSAIE 489

  Fly   572 DVT----FTQARDRFGRMDRKYFIPFFTRR------------FNSQELHECKSQMADLTNKWYQA 620
            |::    ....||::...|||:......||            |:...|.:..|.:|:...:...|
  Rat   490 DISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLA 554

  Fly   621 IRVSPLDSDESDEEIGLAAST 641
            ...||    .:|..:.:..||
  Rat   555 FIRSP----STDNMVNVDFST 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	141/449 (31%)
Slc9a3	XP_038956774.1	b_cpa1	45..644	CDD:273294	167/590 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810