DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a1

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_036784.1	Gene:	Slc9a1 / 24782	RGDID:	3718	Length:	820	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	181/665 - (27%)
Similarity:	312/665 - (46%)	Gaps:	126/665 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDP 86
            :|.|.|.|:.::..:.||.. |..:|...|       .|:|......|.....|..
  Rat    46 TIRGSEPPRERSIGDVTTAP-SEPLHHPDD-------RNLTNLYIEHGAKPVRKAF--------- 93

  Fly    87 PLIDSHAVEQEHNSSLSLFFVI-CVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMS 150
            |::|...:.......:||:.:: |::.:|.    .::.|....:|||.:::.:|..:| .|....
  Rat    94 PVLDIDYLHVRTPFEISLWILLACLMKIGF----HVIPTISSIVPESCLLIVVGLLVG-GLIKGV 153

  Fly   151 GQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY 215
            |:...:.:.:|     |||.||||||.::||.|....|.:|:|:||:||:.||..:|..:|..:|
  Rat   154 GETPPFLQSDV-----FFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLY 213

  Fly   216 LLGL--GEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLT 278
            .:.|  ||....:...::..|||:||||||||.:|:|..:.::.:|::||||||:||||:::||.
  Rat   214 AVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLY 278

  Fly   279 ASITQSANVN----AEASTGEAMFSALKTFCAMFFASAG---IGVIFALISAL---LLKHIDLRK 333
            ....:.|:..    ::...|         |.:.|..|.|   :||::.:|:|.   ...||.:
  Rat   279 HLFEEFASYEYVGISDIFLG---------FLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRV-- 332

  Fly   334 HPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIA 398
               :|...:.:::|..|:.||..|||||||::..|:||..|...|:|..:..|::..::..:.::
  Rat   333 ---IEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVS 394

  Fly   399 ETCVFAYLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFS 463
            ||.:|.:||::..:..||...:|||..::.|||.|...:..|.:.:||||..|:..|.|||:.:.
  Rat   395 ETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYG 459

  Fly   464 GLRGAISYALSLHLNLDSQEKRH-----VIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRAR 523
            ||||||:::|...|     :|:|     :.:|..:.::.||..|.|.:..||:..|...||:..:
  Rat   460 GLRGAIAFSLGYLL-----DKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETK 519

  Fly   524 GSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSE-LTEEEDVT----FTQARDRFG 583
               |:..||                          |.::.|.. ||..||:.    ....:|:..
  Rat   520 ---RSINEE--------------------------IHTQFLDHLLTGIEDICGHYGHHHWKDKLN 555

  Fly   584 RMDRKY---------------FIPFFTRRFNSQELHECKS-------------QMADLTNKWYQA 620
            |.::||               .|.|:.:....|.:...:|             .|.::..|...:
  Rat   556 RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAAS 620

  Fly   621 IRVSPLDSDESDEEI 635
            .|:.|..|.:.:|||
  Rat   621 ERILPALSKDKEEEI 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	138/432 (32%)
Slc9a1	NP_036784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..71		7/25 (28%)
		b_cpa1	99..664	CDD:273294	166/595 (28%)
		Na_H_Exchanger	109..507	CDD:279355	137/426 (32%)
		Interaction with TESC. /evidence=ECO:0000269\|PubMed:18321853	505..571		18/94 (19%)
		Interaction with CHP2. /evidence=ECO:0000250\|UniProtKB:P19634	519..549		9/58 (16%)
		NEXCaM_BD	606..704	CDD:293250	8/30 (27%)
		Interaction with CALM1. /evidence=ECO:0000250\|UniProtKB:P19634	637..820
		Interaction with TESC. /evidence=ECO:0000250\|UniProtKB:P19634	637..820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810