Protein Alignment Nhe1 and Slc9a6

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_036017816.1
• Gene: Slc9a6 / 236794
• MGIID: 2443511
• Length: 732
• Species: Mus musculus
• Alignment Length: 666
• Identity: 207/666 - (31%)
• Similarity: 316/666 - (47%)
• Gaps: 117/666 - (17%)

  Fly    64 SISASGNASTTKRGNASTLVTDPPLIDSHAVEQEH-NSSLSLFFVICVIMLGILLIHSMLQTGFQ 127
            ::|..|..........:|...|..::.....|:.| ..|.:|...|.::.|.||.|........:
Mouse    34 AVSFFGWTGALDGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRAR 98

  Fly   128 YLPESIVVVFLGAFIGLSL-----------NV----------------MSG-------------- 151
            :|.|:.:.:..|..:||.|           ||                :||
Mouse    99 FLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSH 163

  Fly   152 -----QNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIG 211
                 |:....|:..|.|..||.:|||||||.:||:|.:.:||:|:||||.:|..||.||..|||
Mouse   164 ELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIG 228

  Fly   212 AGIY-----LLGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILND 271
            :.:|     :...|::|....|::...||:::||.|||..:||||.|.||..|..|:||||:|||
Mouse   229 SIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLND 293

  Fly   272 AISIVLTASIT--QSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKH 334
            |::|||::||.  |.|..|:......|||.::..|..:|..|..:|....:::||:.|...||:.
Mouse   294 AVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREF 358

  Fly   335 PSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAE 399
            ..||..:..:.:::.::|||....:|::|:|||||..:|||:.||||.:|...:|....|.|:||
Mouse   359 QLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAE 423

  Fly   400 TCVFAYLGLAIFSFK-HQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFS 463
            ..:|:|:||.:|:|: |....:||:.|.:...:|||.||:||:.|:|..|..||.:..|.:|.|:
Mouse   424 NFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFA 488

  Fly   464 GLRGAISYALSLHLNLDSQE-KRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGR 527
            |||||:::||::.   |:.. .|.::.:|||:||.||..|.||.|..:|..|..          |
Mouse   489 GLRGAMAFALAIR---DTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHI----------R 540

  Fly   528 NAAEEGGRR----NGSGRKRSKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRM--- 585
            ..|...|.|    :|...:.:.|: ..:|...|...|.|||.....|...|..::...| ||
Mouse   541 YYARLWGYRDELTHGLYPQEAHSL-FGETDRVGVDSDQEHLGVPDNERRTTKAESAWLF-RMWYN 603

  Fly   586 -DRKYFIPFFT------------------RRFNSQELHECKSQMADLTNKWYQAIRVSPLDSDES 631
             |..|..|..|                  |...|.:.:|.:.|:.|                |:|
Mouse   604 FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKD----------------DDS 652

  Fly   632 DEEIGLAASTSQIHLT 647
            |    |..:...|.||
Mouse   653 D----LILNDGDISLT 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	167/469 (36%)
Slc9a6	XP_036017816.1	b_cpa1	94..>540	CDD:273294	161/458 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720