Protein Alignment Nhe1 and Slc9c1

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_932774.3
• Gene: Slc9c1 / 208169
• MGIID: 2685456
• Length: 1175
• Species: Mus musculus
• Alignment Length: 619
• Identity: 127/619 - (20%)
• Similarity: 245/619 - (39%)
• Gaps: 137/619 - (22%)

  Fly    96 QEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFL----GAF--------------- 141
            :|.:.:|:....|.:..:.:.|:.|:..:..|.|||.|:::.|    |||
Mouse     4 EEISENLTASHSIKLTNMWLELLKSVFLSTPQDLPEIILILSLICTVGAFLNMHLKDFPIPLPVI 68

  Fly   142 ---IGLSLNVMSGQNG---------SWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGS 194
               ||....::|..:.         .|...::     ||.:..|.|||...:::......:....
Mouse    69 LFLIGCCFEILSFASTQIQIYADAIQWMDPDI-----FFGIFTPVIIFNVAFDMDIYMLQKLFWQ 128

  Fly   195 ILVFAIFGTTIS-ALVIGAGIYLLGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPI 258
            |||..|.|..|: .|::.   ||..:.:::  |.......|.:::.:.||:.|.|....|.:...
Mouse   129 ILVITIPGFLINYTLILW---YLQSVNKLS--LKTVPWLLFSAVLISSDPMLTSASIRDLGLSRS 188

  Fly   259 LNMLVFGESILNDAISIVLTASIT----QSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFA 319
            |..|:.|||:|...:|:|:.:.:.    :|.:|| .....:.|.:|.......|..    |::|.
Mouse   189 LTNLINGESLLTSVLSLVIYSGVVHIRFKSKSVN-HTLAHKVMSTAWSYIVESFIT----GIVFT 248

  Fly   320 LISALLLKHI--DLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTV 382
            .:..|.:..|  |...|.:|.|:::.:..|    :.|.:.:|||..:...|:.::. |.|...
Mouse   249 KVIQLWMATIFGDDVNHITLIFSVLYLIFY----VCELVGMSGIFTLATIGLFLNS-TSFKPG-- 306

  Fly   383 TQITMQQTMRTLAFIAETCVFAYLGLAI-------FSFK---HQVELSFVIWAIVLCLIGRACNI 437
            .:..:.:....|:||....||.::||.|       .||.   :.:.:.|.:  |||.|:     :
Mouse   307 VEAFLLEFWNCLSFIGFLMVFTFIGLLIPAHTYLHISFSDVYYSLNIYFTL--IVLRLL-----V 364

  Fly   438 FPLAFLVNKFREHKINNKMQFIMWFSGLRGA--ISYALSL---HLNLDSQEKRHVIITTTLIIVL 497
            |.|...:.....|..:.:..|||.:|.::|.  |:.||.|   .::|.|:.:|..|:... :.|.
Mouse   365 FLLMSPILSRLGHGFSWRWAFIMVWSEMKGTPNINMALLLAYSDISLGSERERSQILFHG-VSVC 428

  Fly   498 FTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSE 562
            ..||::....:|:                  |..:.|.|:.:..| .||:..:          .:
Mouse   429 VITLIVNRFILPM------------------AVTKLGLRDVTSTK-YKSVYYT----------FQ 464

  Fly   563 HLSELTEEEDVTFTQARD----RFGRMDRKYFI--PFFTRRFNSQELHE--------CKSQM--- 610
            |..|||:...:.....:|    .:..:|....:  |:   ..|.:|:.|        |..::
Mouse   465 HFQELTKSTAMALKFDKDLANADWNMVDNAIILQNPY---AMNQEEITEHQKVKCPDCNKEIDET 526

  Fly   611 -----ADLTNKWYQAIRVSPLDSDESDEEIGLAA 639
                 .:|||:...:.:::.......:|.:..:|
Mouse   527 LNIEAMELTNRRLLSAQIASYQRQYRNEVLSQSA 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	104/467 (22%)
Slc9c1	NP_932774.3	Na_H_Exchanger	40..459	CDD:294713	101/467 (22%)
		Ion transport-like	618..698
		Crp	885..>1035	CDD:223736
		CAP_ED	895..1019	CDD:237999
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1137..1175

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810