DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a1

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_058677.1	Gene:	Slc9a1 / 20544	MGIID:	102462	Length:	820	Species:	Mus musculus

Alignment Length:	662	Identity:	182/662 - (27%)
Similarity:	317/662 - (47%)	Gaps:	120/662 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDP 86
            :|.|.|.|:.::..:.||.. |..:|...|       .|:|..|...|...:.|..
Mouse    46 TIRGSEPPRERSIGDVTTAP-SEPLHRPDD-------HNLTNLIIEHGGKPSRKAF--------- 93

  Fly    87 PLIDSHAVEQEHNSS---LSLFFVI-CVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLN 147
            |::|   ::..|..:   :||:.:: |::.:|.    .::.|....:|||.:::.:|..:| .|.
Mouse    94 PVLD---IDYPHVRTPFEISLWILLACLMKIGF----HVIPTISSIVPESCLLIVVGLLVG-GLI 150

  Fly   148 VMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGA 212
            ...|:...:.:.:|     |||.||||||.::||.|....|.:|:|:||:||:.||..:|..:|.
Mouse   151 KGVGETPPFLQSDV-----FFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGG 210

  Fly   213 GIYLLGL--GEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISI 275
            .:|.:.|  ||....:...::..|||:||||||||.:|:|..:.::.:|::||||||:||||:::
Mouse   211 LLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTV 275

  Fly   276 VLTASITQSANVNAEASTG-EAMFSALKTFCAMFFASAGIGVIFALISAL---LLKHIDLRKHPS 336
            ||.....:.|:.:   |.| ..:|....:|..:......:||::.:|:|.   ...||.:
Mouse   276 VLYHLFEEFASYD---SVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRV----- 332

  Fly   337 LEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETC 401
            :|...:.:::|..|:.||..|||||||::..|:||..|...|:|..:..|::..::..:.::||.
Mouse   333 IEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETL 397

  Fly   402 VFAYLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLR 466
            :|.:||::..:..||...:|||..::.|||.|...:..|.:.:||||..|:..|.|||:.:.|||
Mouse   398 IFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLR 462

  Fly   467 GAISYALSLHLNLDSQEKRH-----VIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSG 526
            |||:::|...|     :|:|     :.:|..:.::.||..|.|.:..||:..|...||:..:
Mouse   463 GAIAFSLGYLL-----DKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETK--- 519

  Fly   527 RNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSE-LTEEEDVT----FTQARDRFGRMD 586
            |:..||                          |.::.|.. ||..||:.    ....:|:..|.:
Mouse   520 RSINEE--------------------------IHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFN 558

  Fly   587 RKY---------------FIPFFTRRFNSQELHECKS-------------QMADLTNKWYQAIRV 623
            :||               .|.|:.:....|.:...:|             .|.::..|...:.|:
Mouse   559 KKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKAVTSDRI 623

  Fly   624 SPLDSDESDEEI 635
            .|..|.:.:|||
Mouse   624 LPALSKDKEEEI 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	137/429 (32%)
Slc9a1	NP_058677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..74		8/28 (29%)
		b_cpa1	99..664	CDD:273294	166/589 (28%)
		Na_H_Exchanger	109..507	CDD:279355	136/420 (32%)
		Interaction with TESC. /evidence=ECO:0000250\|UniProtKB:P19634	507..549		12/70 (17%)
		Interaction with CHP2. /evidence=ECO:0000250\|UniProtKB:P19634	519..549		9/58 (16%)
		NEXCaM_BD	606..704	CDD:293250	8/30 (27%)
		Interaction with CALM1. /evidence=ECO:0000250\|UniProtKB:P19634	637..820
		Interaction with TESC. /evidence=ECO:0000250\|UniProtKB:P19634	637..820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810