DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a5

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_620213.1	Gene:	Slc9a5 / 192215	RGDID:	620473	Length:	898	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	169/573 - (29%)
Similarity:	276/573 - (48%)	Gaps:	75/573 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PSISASGNASTTKRGNASTLVTDPPLI-----DSHAVEQEHNSSLSLFFVICVIMLGILLIHSML 122
            |.:..:|..:|.:.......:.:||.:     ..|.||..:..:|    .|.|..|..::.| :.
  Rat    10 PGLPLAGVGATEEPTQEPGPLGEPPGLALFRWQWHEVEAPYLVAL----WILVASLAKIVFH-LS 69

  Fly   123 QTGFQYLPESIVVVFLG-AFIGLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKG 186
            :.....:|||.:::.|| |..|:.|.|..      |.|....|..|||.|||||:.:|||.:...
  Rat    70 RKVTSLVPESCLLILLGLALGGIVLAVAK------KAEYQLEPGTFFLFLLPPIVLDSGYFMPSR 128

  Fly   187 NFFQNIGSILVFAIFGTTISALVIGAGIY-LLGLGEVAFRL--SFSESFAFGSLISAVDPVATVA 248
            .||.|:|:||.:|:.||..:|...|..:: |...|.||.|:  ...:...||||||||||||.:|
  Rat   129 LFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLA 193

  Fly   249 IFHALDVDPILNMLVFGESILNDAISIVL---TASITQSANVNAEASTGEAMFSALKTFCAMFFA 310
            :|..:.|:..|.::|||||:||||::.||   ..|..:..:.|.:|:      ..||...::|..
  Rat   194 VFEEVHVNETLFIIVFGESLLNDAVTAVLYKVCNSFVEMGSANVQAT------DYLKGVASLFVV 252

  Fly   311 SAG---IGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMS 372
            |.|   :|::||.:.||..:.  .::...:|..::.:..||.|:.||...||.|:|:..||:...
  Rat   253 SLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCK 315

  Fly   373 HYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGL-AIFSFKHQVELSFVIWAIVLCLIGRACN 436
            .|...|:|..::..::.||:|||..|||.:|..||: |:.|.|...:...|:..:...|..||..
  Rat   316 KYVEANISHKSRTAVKYTMKTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALG 380

  Fly   437 IFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTL 501
            :....:::|:||...::...|.:|.:.|||||:::||.:.|:......:...:.||:::|.||.:
  Rat   381 VVLQTWVLNQFRLAPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVI 445

  Fly   502 VLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSE 566
            |.|.:..||:|:|:.                         |||.....:..:|.     .||..:
  Rat   446 VQGLTIKPLVKWLRV-------------------------KRSDYHKPTLNQEL-----HEHTFD 480

  Fly   567 --LTEEEDVT----FTQARDRFGRMDRKYFIPFFTRRFNSQELHECKSQMADL 613
              |...|||.    :...|||:.:.|:||......||    ..:..:.|:.|:
  Rat   481 HILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRR----SAYRIRDQIWDV 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	140/425 (33%)
Slc9a5	NP_620213.1	b_cpa1	43..632	CDD:273294	164/540 (30%)
		Na_H_Exchanger	52..457	CDD:279355	139/423 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..692
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810