Protein Alignment Nhe1 and Slc9a5

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_620213.1
• Gene: Slc9a5 / 192215
• RGDID: 620473
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 169/573 - (29%)
• Similarity: 276/573 - (48%)
• Gaps: 75/573 - (13%)

  Fly    63 PSISASGNASTTKRGNASTLVTDPPLI-----DSHAVEQEHNSSLSLFFVICVIMLGILLIHSML 122
            |.:..:|..:|.:.......:.:||.:     ..|.||..:..:|    .|.|..|..::.| :.
  Rat    10 PGLPLAGVGATEEPTQEPGPLGEPPGLALFRWQWHEVEAPYLVAL----WILVASLAKIVFH-LS 69

  Fly   123 QTGFQYLPESIVVVFLG-AFIGLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKG 186
            :.....:|||.:::.|| |..|:.|.|..      |.|....|..|||.|||||:.:|||.:...
  Rat    70 RKVTSLVPESCLLILLGLALGGIVLAVAK------KAEYQLEPGTFFLFLLPPIVLDSGYFMPSR 128

  Fly   187 NFFQNIGSILVFAIFGTTISALVIGAGIY-LLGLGEVAFRL--SFSESFAFGSLISAVDPVATVA 248
            .||.|:|:||.:|:.||..:|...|..:: |...|.||.|:  ...:...||||||||||||.:|
  Rat   129 LFFDNLGAILTYAVVGTLWNAFTTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLA 193

  Fly   249 IFHALDVDPILNMLVFGESILNDAISIVL---TASITQSANVNAEASTGEAMFSALKTFCAMFFA 310
            :|..:.|:..|.::|||||:||||::.||   ..|..:..:.|.:|:      ..||...::|..
  Rat   194 VFEEVHVNETLFIIVFGESLLNDAVTAVLYKVCNSFVEMGSANVQAT------DYLKGVASLFVV 252

  Fly   311 SAG---IGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMS 372
            |.|   :|::||.:.||..:.  .::...:|..::.:..||.|:.||...||.|:|:..||:...
  Rat   253 SLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCK 315

  Fly   373 HYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGL-AIFSFKHQVELSFVIWAIVLCLIGRACN 436
            .|...|:|..::..::.||:|||..|||.:|..||: |:.|.|...:...|:..:...|..||..
  Rat   316 KYVEANISHKSRTAVKYTMKTLASSAETVIFMLLGISAVDSSKWAWDSGLVLGTLFFILFFRALG 380

  Fly   437 IFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTL 501
            :....:::|:||...::...|.:|.:.|||||:::||.:.|:......:...:.||:::|.||.:
  Rat   381 VVLQTWVLNQFRLAPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVI 445

  Fly   502 VLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSE 566
            |.|.:..||:|:|:.                         |||.....:..:|.     .||..:
  Rat   446 VQGLTIKPLVKWLRV-------------------------KRSDYHKPTLNQEL-----HEHTFD 480

  Fly   567 --LTEEEDVT----FTQARDRFGRMDRKYFIPFFTRRFNSQELHECKSQMADL 613
              |...|||.    :...|||:.:.|:||......||    ..:..:.|:.|:
  Rat   481 HILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRR----SAYRIRDQIWDV 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	154/502 (31%)
Slc9a5	NP_620213.1	Na_H_Exchanger	43..632	CDD:470090	164/540 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	660..692
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..888