Protein Alignment Nhe1 and nhx-5

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001024720.1
• Gene: nhx-5 / 181258
• WormBaseID: WBGene00003733
• Length: 630
• Species: Caenorhabditis elegans
• Alignment Length: 646
• Identity: 185/646 - (28%)
• Similarity: 303/646 - (46%)
• Gaps: 144/646 - (22%)

  Fly    44 SSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDPPLIDSHAVEQEHNSSLSLFFVI 108
            |:|..:|.....|..||....::|...||...|.:...|:|                      .:
 Worm     8 STILLISSTVAGSNNGNTRLDMAAQRRASNIHRMDTIILLT----------------------YV 50

  Fly   109 CVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIG-----LSLNVMSGQ---------------- 152
            .|::|.::...:.....|:::.||.|.:|.|..||     ..|.::..|
 Worm    51 SVMVLIVVTAWAFKHYRFRFIHESGVTLFYGLLIGFVIRYFGLGLLQSQTFDVITKNKTIVKEPP 115

  Fly   153 ----------NGS-----------------------WKREEVFSPMGFFLVLLPPIIFESGYNLH 184
                      .||                       .:::.||||..||.:|:|||||.:||:|.
 Worm   116 DYLMLEVKPEGGSRVSFHYELIEGFFADKRKKIEQQIEQKSVFSPEVFFNMLIPPIIFNAGYSLK 180

  Fly   185 KGNFFQNIGSILVFAIFGTTISALVIG------AGIYLLGLGEVAFRLSFSESFAFGSLISAVDP 243
            |.:||:||||||.....|||||....|      ..|:.:|       .||.|...||:||||.||
 Worm   181 KRHFFRNIGSILAIVFIGTTISCFGTGCLMFVFTSIFQMG-------YSFKELLFFGALISATDP 238

  Fly   244 VATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMFSALKTFCAMF 308
            |..:::|:.::|:..|..|:||||.||||::||| :.:.::.:.::||.|.:...||:..|..:|
 Worm   239 VTIISVFNDMNVEADLFALIFGESALNDAVAIVL-SEVIENFSTSSEAITLQDFGSAIAGFAGVF 302

  Fly   309 FASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSH 373
            |.|..:|.:...::|.|.|...:.:|..||.::.::.:|..:::||...|:||:::|||||..:|
 Worm   303 FGSLMLGFMIGCMNAFLTKMTLISEHALLESSLFVLISYISFLVAEVCGLTGIVSVLFCGIAQAH 367

  Fly   374 YTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQ-VELSFVIWAIVLCLIGRACNI 437
            ||:.|||..:|...:.....::||.|:.:|.|:|:::|...:| ...||::::::.....||..:
 Worm   368 YTYNNLSDESQSNTKHFFHMVSFIMESFIFCYIGVSVFVTNNQRWSFSFLLFSLISITASRALFV 432

  Fly   438 FPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLV 502
            :||::|:|..|..||..:.|.::.|:|||||:::||:....  |.|.|.:|..||..:|:.|.||
 Worm   433 YPLSWLLNIRRRPKIPKRYQHMILFAGLRGAMAFALAGRNT--STENRQMIFATTTAVVIVTVLV 495

  Fly   503 LGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSEL 567
            .||.|..::.||:       ...|::|.||       |::...|:|.|..        .:| |:|
 Worm   496 NGGLTSWMIDYLQ-------IKHGKDAIEE-------GQRLENSMSSSPA--------DQH-SDL 537

  Fly   568 TEEEDVTFTQARDRFGRMDRKYFIPFFTRRFNSQELHECKSQMADLTNKWY--QAIRVSPL 626
            .|...||.:...:.:.    |.|:|                      .|||  .|..:.||
 Worm   538 DESVPVTMSPGLNPWD----KAFLP----------------------RKWYHFDASFMKPL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	149/475 (31%)
nhx-5	NP_001024720.1	NhaP	152..470	CDD:223104	121/325 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D242793at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820