Protein Alignment Nhe1 and F41E7.2

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_509723.2
• Gene: F41E7.2 / 181235
• WormBaseID: WBGene00009618
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 607
• Identity: 107/607 - (17%)
• Similarity: 210/607 - (34%)
• Gaps: 210/607 - (34%)

  Fly    22 SISGQEV--PQSKTSSNTTTTDNSSS--IHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTL 82
            ||:||..  |.|..:||:....|:::  :|::...|:     .|..:::|         |.....
 Worm    41 SITGQNFLHPLSPVTSNSLNLQNAANEVLHSIISCFM-----MVVLAVAA---------GKLVKF 91

  Fly    83 VTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTG--------FQYLPESIVVVFLG 139
            :..|.||.                  | :::||.: .::.|.|        :|::...:.:|.:.
 Worm    92 IYTPSLIG------------------C-MLVGIAM-RNVPQFGELFYINEYWQFILRKLSLVVII 136

  Fly   140 AFIGLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTT 204
            ...|:|:||.     ..|:..:|          |||:              .:||....|:
 Worm   137 IRWGISINVR-----FIKKNYIF----------PPIL--------------GLGSAFSEAL---- 168

  Fly   205 ISALVIGAGIYL---LGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHAL------------D 254
              |:...|.::.   |.||.:.           |.:::.|.|...:.....|            |
 Worm   169 --AICFTACVFFDFPLSLGLIC-----------GFVVATVSPAVGMPTMIRLKEQGIGTTNNIPD 220

  Fly   255 V-------DPILNMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMF-SALKTFCAMFFAS 311
            |       |.::::|:|.           :|:|:|         .|.:|.| :.:|:..|:..|:
 Worm   221 VVPAACCFDNVVSLLIFS-----------VTSSVT---------FTHDAFFLTMVKSIGAIVLAA 265

  Fly   312 AGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSG------IMAILFCGIV 370
                 |...:...||:......:....||..|:.....|.:...:.:.|      :.|:..|.:.
 Worm   266 -----IIGCVIGWLLRWFPKNDNRHTHFARFLVIASPAYAVITSMLILGYAFPGIVSALCICCVS 325

  Fly   371 MSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQV----ELSFVIWAI----- 426
            .:|:...|...: ::.:.|......|:|...:|:.:|.. |.|::..    :.:|:|.|:
 Worm   326 TTHWREDNPKGI-KVLVHQFDNLWYFVAVPLLFSLVGYT-FDFQNMSAENWKTAFIIIAVGSSFR 388

  Fly   427 ---------------------VLCLIGRA---CNIFP-LAFLVNKFREHKINNKMQFIMWFSGLR 466
                                 .|.|:.:|   |.:.| |.|:.|.|.|.:...|:
 Worm   389 LISAMILSYYGHFNIYEQIILALTLMPKATVQCALAPSLIFMTNGFPELREQTKL---------- 443

  Fly   467 GAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAE 531
             .|:..::.           |::|:.::.:|...|.      |.:..:|.|.....|....:...
 Worm   444 -IINICITA-----------VMVTSPIVEILLDVLA------PRILKIKEGTSTYNRNITNSTIL 490

  Fly   532 EGGRRNGSGRKRSKSISLSKTR 553
            :....|...:|.|.|.|.:.:|
 Worm   491 DEMDPNLELKKTSSSNSTNNSR 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	89/514 (17%)
F41E7.2	NP_509723.2	NhaP	70..>479	CDD:439796	91/543 (17%)