DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and nhx-4

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001024562.1	Gene:	nhx-4 / 180964	WormBaseID:	WBGene00003732	Length:	749	Species:	Caenorhabditis elegans

Alignment Length:	594	Identity:	149/594 - (25%)
Similarity:	273/594 - (45%)	Gaps:	110/594 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LVHAGPESISGQ-EVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGN 78
            |::..||:.:.. |.||: .::||:.||.                     |:.|.|
Worm    37 LLNTVPENFTNNIEYPQN-NNNNTSETDE---------------------SMDAEG--------- 70

  Fly    79 ASTLVTDPP--------LIDSHAVEQEH-NSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIV 134
             ..:.:.||        |:|...|:.|| :..|:..|:|.::.|....:|..:   .:.||||:|
Worm    71 -EWVQSAPPEEIEEAKHLLDPVHVDFEHTHKPLAFVFLIILVTLAKPTLHWPV---LRKLPESVV 131

  Fly   135 VVFLGAFIGLSLNVM----SGQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSI 195
            ::..|..:..::..:    .||..::.         ||::|||.|:.::|.::.|..|...:..|
Worm   132 LMLYGVLMATAVKALMRIDPGQLDTFM---------FFMILLPAIVNDAGLSMQKKEFTIALPKI 187

  Fly   196 LVFAIFGTTISALVIGAGIYLLGLGEV-AFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPIL 259
            |:||:.||.:.||::.|.:|  |:..: :|:..|...|.|.:||||||||:.::.|..|||...|
Worm   188 LLFAVVGTVVHALLLAATMY--GIEPIFSFKPGFLHLFVFATLISAVDPVSVLSTFAELDVKKSL 250

  Fly   260 NMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMF---SALKTFCAMFFASAGIGVIFALI 321
            .:|:||||:.|||::|||..:   |.||...:...:.|.   |.:.:....|....|.|::...:
Worm   251 FILIFGESLCNDAVTIVLYRT---SINVIKTSDASDEMLTITSVVGSCVVQFMIVCGFGLLCGAV 312

  Fly   322 ----SALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTV 382
                ...::|  ::..|...:....|...|..|:|||..|.|||:|.:.|..:||:|...|:...
Worm   313 VGFAGVFIMK--NMVGHQMNQPIFQLFCPYLAYLLAETGHYSGILASILCAAIMSYYMAANMCVE 375

  Fly   383 TQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKF 447
            .:.......:|.:.::|:|:|.|||:::.|:.|:.:..|:...:..|.:.|......|:...|.|
Worm   376 MEFAAFTFSKTGSSLSESCIFFYLGVSLVSYNHEFDFYFIAVTVFCCTLYRFLVTCTLSAFYNLF 440

  Fly   448 REHKINNKM----QFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTM 508
            ...|  |::    |.::..:|:|||:.:.|...::......:...:||||.::..|:::.|.:..
Worm   441 ASEK--NRIPFTDQLVVTHAGIRGAVCFGLVQIIDERIIPAKPYFVTTTLAMIFVTSILQGCTIK 503

  Fly   509 PLLKYLK-PGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTREWGQAIDSEHLSELTEEE- 571
            .::|.|| ||.                  :|:.:|..|::      .|...::.:::.:....|
Worm   504 FVMKCLKIPGD------------------DGTKQKDPKAL------RWLTHLNDKYIKKFLVSEN 544

  Fly   572 -----DVTF 575
                 |.||
Worm   545 TYLPTDETF 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	117/430 (27%)
nhx-4	NP_001024562.1	b_cpa1	94..637	CDD:273294	131/505 (26%)
nhx-4	NP_001024562.1	Na_H_Exchanger	104..508	CDD:279355	115/424 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810