Protein Alignment Nhe1 and nhx-2

DIOPT Version :9

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_495614.4
• Gene: nhx-2 / 174242
• WormBaseID: WBGene00003730
• Length: 644
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 153/580 - (26%)
• Similarity: 273/580 - (47%)
• Gaps: 77/580 - (13%)

  Fly    95 EQEHNS----------SLSLFFVICVIMLG---ILLIHSMLQTGFQYLPESIVVVFLGAFIGLSL 146
            |:|:.|          ::.:...||:.::|   ..:|.:::....:..|:|.:::.:|..||:..
 Worm    29 EKEYPSRYPIAYFEWENVKIPMTICLWLIGASIAKIIFNLIPHLNELFPDSALLIMIGLIIGIIF 93

  Fly   147 NVMS-GQNGSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVI 210
            .::. .:|..:...||     |.|.||||::|::||.:....||.|.||||.||:.||:.:.:.|
 Worm    94 KLIGVNKNAFFLESEV-----FMLYLLPPLVFDAGYFMPARQFFDNFGSILCFAMIGTSFNIVAI 153

  Fly   211 GAGIYLLGL-GEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAIS 274
            ...::.:.| |..:..........|||:.:.|||||.:.||..|.|:.:|.:.|||||:|||.::
 Worm   154 ALSLWAISLTGLFSVETPLMHMLLFGSVAADVDPVAVIVIFEELKVNEVLFIAVFGESLLNDGVA 218

  Fly   275 IVLTASITQSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEF 339
            :||.......:.:..|........:...:|..:.|...|||::||.:::|:.:.....:...|..
 Worm   219 VVLYRMFLTFSEIGTENLITSDYINGGVSFLVVAFGGIGIGLLFAFLTSLVTRFARDEEVKVLNS 283

  Fly   340 AMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFA 404
            ..:|:..|..|:..|...||.||||:|||..|..|...|:...|....:..::.|:..:||.:|.
 Worm   284 VFILILPYTCYLCGELFGLSSIMAIVFCGAAMRQYCRENVDPDTVKATESFIKVLSLASETVIFV 348

  Fly   405 YLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAI 469
            :|||:..|..|..:.||::..:|.|||.|...:..:.:.:||:|.:|.....||||.:.||||||
 Worm   349 FLGLSTVSSNHHWDTSFIVLTVVFCLIYRTLGVVVMCYFLNKYRLNKYTKVDQFIMAYGGLRGAI 413

  Fly   470 SYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGG 534
            :|.|.:.:. |....:::.:|:.:|::.||..:.|.:..|:.::|:..||
 Worm   414 AYGLVVAIP-DFIPGKNMFVTSCIIVIYFTVFLQGITLKPIAEFLQVEKK--------------- 462

  Fly   535 RRNGSGRKRSKSISLSKTREWGQAIDSEHL-SELTEE-----EDVTFTQA----RDRFGRMDRKY 589
                  ...||::             .||: |||.:.     ||:...:.    ||.:..::..|
 Worm   463 ------NVHSKNM-------------IEHIYSELIDTTMAGMEDIAGFKGHHWIRDSWNALNNNY 508

  Fly   590 FIPFFTRRFNSQELHECKSQMADLTNKWYQAIRVSPLDSDESDEEIGLAASTSQIHLTRS 649
            ..|....:.|.:|:.:.|     |..|:...:       ||..::|......|.:..|::
 Worm   509 LRPILVNKNNMKEMDKTK-----LVRKYKHLV-------DEDAKKIARGDLNSNMVFTKA 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	125/429 (29%)
nhx-2	NP_495614.4	Na_H_Exchanger	103..455	CDD:279355	114/357 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810