Protein Alignment Nhe1 and SLC9B1

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_631912.3
• Gene: SLC9B1 / 150159
• HGNCID: 24244
• Length: 515
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 120/597 - (20%)
• Similarity: 214/597 - (35%)
• Gaps: 197/597 - (32%)

  Fly    17 HAGPESISGQEVPQSKTSSNTTTTDNSSSI---------HTVSDVFVNSPLGNVTPSISASGNAS 72
            |...|:......|||....|.|..:.:.::         .|..:.:::.||
Human    10 HLEDENFQTSTTPQSLIDPNNTAQEETKTVLSDTEEIKPQTKKETYISCPL-------------- 60

  Fly    73 TTKRGNASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPE----SI 133
               ||..:.::|:..::                |||..:...||        |.:.||.    .:
Human    61 ---RGVLNVIITNGVIL----------------FVIWCMTWSIL--------GSEALPGGNLFGL 98

  Fly   134 VVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMGFFLVLLPPII--FESGYNLHKGNFFQ------ 190
            .::|..|.||       |:.....|..:..|       |||::  ..:|:.:....|..
Human    99 FIIFYSAIIG-------GKILQLIRIPLVPP-------LPPLLGMLLAGFTIRNVPFINEHVHVP 149

  Fly   191 NIGSILVFAIFGTTISALVIGAGI-----YLLGLGEVAFRLS-------------FSE------- 230
            |..|.::.:|   .::.::|.||:     .|..|..|.|||:             ||.
Human   150 NTWSSILRSI---ALTIILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPW 211

  Fly   231 --SFAFGSLISAVDPVATVAIFHALD-----VDPILNMLVFGESILNDAISIVLTASITQSANVN 288
              :|..|.::.||.|...|.....|.     |:..:..|:...|.::|.::|
Human   212 QWAFLLGFVLGAVSPAVVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAI------------- 263

  Fly   289 AEASTGEAMFSALKTFCAMFFASAGI---------GVIFALISALLLKHIDLRKHPSLE------ 338
                ||      ..|..::.|:|.||         .|..:|::.::|... :|..||.:
Human   264 ----TG------FNTCLSIVFSSGGILNNAIASIRNVCISLLAGIVLGFF-VRYFPSEDQKKLTL 317

  Fly   339 ---FAMMLMFTYAPYVLAE---GIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFI 397
               |.::.|...|  ||..   |:|.||.:    |.:|:|.......|. .::.:|:.:.|:..|
Human   318 KRGFLVLTMCVSA--VLGSQRIGLHGSGGL----CTLVLSFIAGTKWSQ-EKMKVQKIITTVWDI 375

  Fly   398 AETCVFAYLG--LAIFSFKHQ-VELSFVIWAIVLCLIGRACNIFPL-AFLVNKFREHKINNKMQF 458
            .:..:|..:|  :::.|.:.. |.:|....::.||:  |....:.| .|....|:| ||     |
Human   376 FQPLLFGLVGAEVSVSSLESNIVGISVATLSLALCV--RILTTYLLMCFAGFSFKE-KI-----F 432

  Fly   459 I--MWF-SGLRGAISYALSL--------HLNLDSQEKRHVIITTTLIIVLFT----TLVLG--GS 506
            |  .|. .....|:...|:|        ||...:::    ::|...:.:|.|    .|::|  |.
Human   433 IALAWMPKATVQAVLGPLALETARVSAPHLEPYAKD----VMTVAFLAILITAPNGALLMGILGP 493

  Fly   507 TMPLLKYLKPGK 518
            .| |.::..|.|
Human   494 KM-LTRHYDPSK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	104/494 (21%)
SLC9B1	NP_631912.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		6/21 (29%)
		NhaP	140..513	CDD:439796	88/412 (21%)