DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe1 and SLC9B2

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001357130.1	Gene:	SLC9B2 / 133308	HGNCID:	25143	Length:	537	Species:	Homo sapiens

Alignment Length:	403	Identity:	80/403 - (19%)
Similarity:	135/403 - (33%)	Gaps:	135/403 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSML---QTGFQYLPESIVVVFLGA 140
            |..|:.:.|:|:.: |:.:|..|.||    ..|.|.|:|:.:.|   ....:.|....|.:.:|.
Human   152 AGFLIRNIPVINDN-VQIKHKWSSSL----RSIALSIILVRAGLGLDSKALKKLKGVCVRLSMGP 211

  Fly   141 FI------GLSLNVMSGQNGSWKREEVFSPMGFFL----------VLLPPIIF--ESGYNLHKGN 187
            .|      .|..:.:.|....|         ||.|          |::|.::.  ..||.:.||
Human   212 CIVEACTSALLAHYLLGLPWQW---------GFILGFVLGAVSPAVVVPSMLLLQGGGYGVEKG- 266

  Fly   188 FFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFSESFAFGS--------LISAVDPV 244
                             :..|::.||.:...|....|......:|:.||        ::..|..|
Human   267 -----------------VPTLLMAAGSFDDILAITGFNTCLGIAFSTGSTVFNVLRGVLEVVIGV 314

  Fly   245 AT-------VAIFHALDVDPIL---NMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMFS 299
            ||       :..|.:.|.|.::   ..||.|.|:|                          |:||
Human   315 ATGSVLGFFIQYFPSRDQDKLVCKRTFLVLGLSVL--------------------------AVFS 353

  Fly   300 ALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAI 364
                  ::.|...|.|.:..|:.|               |...:.:|      :|...:..|:|:
Human   354 ------SVHFGFPGSGGLCTLVMA---------------FLAGMGWT------SEKAEVEKIIAV 391

  Fly   365 -------LFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFV 422
                   |..|::.:..:..:|...|......|:.....|.....|..:..|.|:.|.::.:||.
Human   392 AWDIFQPLLFGLIGAEVSIASLRPETVGLCVATVGIAVLIRILTTFLMVCFAGFNLKEKIFISFA 456

  Fly   423 IW---AIVLCLIG 432
             |   |.|...||
Human   457 -WLPKATVQAAIG 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	74/382 (19%)
SLC9B2	NP_001357130.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
SLC9B2	NP_001357130.1	Na_H_Exchanger	176..537	CDD:351397	72/378 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810