Protein Alignment Nhe1 and Nha1

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_061496802.1
• Gene: Nha1 / 1281378
• VectorBaseID: AGAMI1_000233
• Length: 654
• Species: Anopheles gambiae
• Alignment Length: 555
• Identity: 117/555 - (21%)
• Similarity: 200/555 - (36%)
• Gaps: 173/555 - (31%)

  Fly   107 VICVIMLGILL-IHSMLQTGFQYLPE----SIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSPMG 166
            ::.:|::|:|| |.:.:..|....|.    .:||:.:.|..|                      |
Mosquito   159 ILSIILIGVLLWITAFVIIGDTAAPGGQLFQLVVLTVAANFG----------------------G 201

  Fly   167 FFLVL--LPPIIFESGYNLHKGNFFQNIG--------SILVFAIFGTTISALVIGAG-------- 213
            |.:.|  ||.:|   |. |..|..|||:|        .|:...:....:..::|.||
Mosquito   202 FLISLTTLPRLI---GM-LMVGILFQNVGWVNLDGEFQIVTAELRKLALVIILIRAGLEMDPTAF 262

  Fly   214 --IY--LLGLGEVAF---------------RLSFSESFAFGSLISAVDPVATVAIFHALDVD--- 256
              ||  :|.||.:.:               :|.:..|...||::.||.|...|.....|...
Mosquito   263 KKIYKTILKLGLIPWFVECSLIAVCARFFLQLPWMWSILLGSIVGAVSPAVVVPCLFRLRTKGYG 327

  Fly   257 -----PILNMLVFGESILNDAISIV---LTASI---TQSANVN-AEASTGEAMFSALKTFCAMFF 309
                 |.|.:.|.|   ::||:|:.   :.:||   |||..:. |:|..           |.:
Mosquito   328 VVKGIPTLIIAVAG---IDDAVSVAGFGIISSIMFSTQSLGLQIAQAPV-----------CII-- 376

  Fly   310 ASAGIGVIFALISALLLKHIDLRKHPSLEFAMML--MFTYAPYVLA----EGIHLSGI--MAILF 366
              .|:|  |.::...|.|::   ..|...:.:.:  :..:...:||    |.||..|.  :.::|
Mosquito   377 --GGLG--FGVVWGFLCKYV---PEPGDAYVVPIRTLMLFGGGLLAVFGSEEIHFEGAGPLGVVF 434

  Fly   367 CGIVMSHY--------THFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFK---HQVELS 420
            .....|::        ....:||..:|        ...|.|..:|...|.:|...:   |.|.:.
Mosquito   435 AAFTASYFWCGQGWELEDNPVSTAFEI--------FWMIFEPILFGITGASIKIAELDPHIVSIG 491

  Fly   421 FVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQF---IMWFS--GLRGAIS-YALSLHLNL 479
              :.:|....:.|......:||      ..|:|.|.:.   |.|.|  .::.|:. .||...::.
Mosquito   492 --VGSIYAVAVIRILTTVAIAF------GDKLNVKEKIFVAISWMSKATVQAALGPVALKTVMSN 548

  Fly   480 DSQEKRHV----IITTTLIIVLFTTLVLGGSTMPL--LKYLKPGKKRRARGSGRNAAEEGGRRNG 538
            :::.:..|    ::....|:.:..|..||...:.:  .|.||..|::.....|    ..|.||
Mosquito   549 ENRTEEEVHYAELVKMVCILSIILTAPLGAILISVTGTKLLKKTKQQLEPLDG----TLGWRR-- 607

  Fly   539 SGRKRSKSISLSKTREWGQAIDSEHLSELTEEEDV 573
            |.|.....||:         ||.|.     |.||:
Mosquito   608 SHRPSLHDISI---------IDEEE-----EREDI 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	117/551 (21%)
Nha1	XP_061496802.1	None