Protein Alignment Nhe1 and Nhe3

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_061518597.1
• Gene: Nhe3 / 1275569
• VectorBaseID: AGAMI1_006807
• Length: 733
• Species: Anopheles gambiae
• Alignment Length: 653
• Identity: 189/653 - (28%)
• Similarity: 307/653 - (47%)
• Gaps: 137/653 - (20%)

  Fly    89 IDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNV----- 148
            :|:.|.:.....||:|.....::.|.:|.|.........:|.|:.:.|..|..:|..:..
Mosquito    49 LDAKANKIHQIDSLNLLLYTFLLTLTVLTIWLFKHRRVSWLHETGLAVIYGLIVGAIIRYAGTTT 113

  Fly   149 -------------------------------------------------MSGQNGSWKREEV--- 161
                                                             ..|:.|:.:..|:
Mosquito   114 PIIHVSVEAEPDAKFNQSLPPDTLWLKFPGNLPHGSDQPVKANKTYTYSFRGELGNVEENEIDLK 178

  Fly   162 --FSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAF 224
              |.|..||.::||||||.:||:|.:..||:|:|:||:|||.|||:||.:|||.:|  |..::..
Mosquito   179 ATFDPEVFFNIILPPIIFHAGYSLKRKYFFRNLGAILMFAIIGTTLSAFLIGALMY--GFVQLMP 241

  Fly   225 RL----SFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQ-- 283
            :|    :|.::..||:|||..||:..:|||..:.||..|..||||||:||||::|||:.:|..
Mosquito   242 KLKSSFTFLDTLYFGALISPTDPLTILAIFSDMHVDVNLYALVFGESVLNDAVAIVLSGAIQNYG 306

  Fly   284 ---SANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMF 345
               |:|...|   |.|...:|..|.::|..|..||.....::|::.|...:|..|.||.|:.::.
Mosquito   307 EHYSSNGEFE---GHAFLRSLGDFFSVFAFSLLIGASMGCVTAMMTKFTRIRDFPLLESALFVLM 368

  Fly   346 TYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAI 410
            :|:.:::||...|:|::|:|||||..:|||:.|||..::...:|....|.|:||..:|:|:|:::
Mosquito   369 SYSTFLIAEAAELTGVVAVLFCGICQAHYTYNNLSDDSRTRTKQIFELLNFLAENFIFSYIGVSM 433

  Fly   411 FSF-KHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALS 474
            |:| ||..:..|:....:...||||.||:||:.|:|..|:.||:...|.:::|:|||||:|:||:
Mosquito   434 FTFPKHHFDPLFIFTGFMCAAIGRAVNIYPLSALLNIARKPKISWNFQHMLFFAGLRGAMSFALA 498

  Fly   475 LHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLK------------PGKKRRARGSGR 527
            :...:  .:.|..::|||.:||:.|.::.||:...||.:|.            |.:..|   |..
Mosquito   499 IRNTV--SDARQAMLTTTSLIVITTVIIQGGAANFLLNWLNIPVGVDDETEVLPYQGVR---SVY 558

  Fly   528 NAAEEGGRRNGSG-------------RKRSKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQAR 579
            |:.|     |.:|             .:|:.|:.|                |..:.|..|.....
Mosquito   559 NSME-----NTAGSIDVGLNLSQLQVNRRASSLDL----------------ENPDSEGATTPGGT 602

  Fly   580 DR----------FGRMDRKYFIPFFT--RRFNSQELHECKSQMADLTNKWYQAIRVSPLDSDESD 632
            .|          :|..|.:|..|..|  |....:.|..|.|.:|.|.....|..:..|....:||
Mosquito   603 RRGHEKAVLARLWGNFDSRYMKPLLTHSRPTLLETLPVCLSPLARLLTTTEQLTQDGPTRRSDSD 667

  Fly   633 EEI 635
            .::
Mosquito   668 SDL 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	174/591 (29%)
Nhe3	XP_061518597.1	None