Protein Alignment Nhe1 and Nhe1

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_061515684.1
• Gene: Nhe1 / 1269244
• VectorBaseID: AGAMI1_006232
• Length: 678
• Species: Anopheles gambiae
• Alignment Length: 639
• Identity: 459/639 - (71%)
• Similarity: 519/639 - (81%)
• Gaps: 49/639 - (7%)

  Fly     6 AYSAAALLLLVHAGPESISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPS-ISASG 69
            |.|.:.:|..:|.|..|:|                  :|::.||       |..:..|: .:|:|
Mosquito    52 AASPSVVLAAIHHGNASVS------------------ASTVATV-------PSASPAPAPATANG 91

  Fly    70 NASTT----KRGNAST-LVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYL 129
            .|:|.    ..||.|| ..|..|  :..||||||.||:|:|||:|||.|||||||.|||||||||
Mosquito    92 TAATATAPPNGGNTSTSSATMSP--EKSAVEQEHYSSMSIFFVLCVIALGILLIHMMLQTGFQYL 154

  Fly   130 PESIVVVFLGAFIGLSLNVMSGQN-GSWKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIG 193
            |||||||||||.|||.|||.|.:: .:|:|||||||..|||||||||||||||||||||||||||
Mosquito   155 PESIVVVFLGALIGLILNVSSVKHIANWEREEVFSPTAFFLVLLPPIIFESGYNLHKGNFFQNIG 219

  Fly   194 SILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPI 258
            |||||||.||||||||||:|:|||||.|||:||:|.||||||||||||||||||||||||||||:
Mosquito   220 SILVFAIIGTTISALVIGSGVYLLGLAEVAYRLNFVESFAFGSLISAVDPVATVAIFHALDVDPV 284

  Fly   259 LNMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISA 323
            ||||||||||||||||||||.::....: ::.:||||::||||.|||.||||||||||:|||:||
Mosquito   285 LNMLVFGESILNDAISIVLTTTVMPMVS-DSGSSTGESIFSALNTFCMMFFASAGIGVVFALMSA 348

  Fly   324 LLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQ 388
            |||||:||||||||||.:||:||||||||||||||||||||||||||||||||||||||||||||
Mosquito   349 LLLKHVDLRKHPSLEFGLMLVFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQ 413

  Fly   389 QTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKIN 453
            |||||||||||||||||||||||||||:.||||||||||||||||||||||||:|||:||||||.
Mosquito   414 QTMRTLAFIAETCVFAYLGLAIFSFKHRCELSFVIWAIVLCLIGRACNIFPLAWLVNRFREHKIT 478

  Fly   454 NKMQFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGK 518
            |:|.|||||||||||||||||||:...::|.|||:|||||||||||||..|||||||:|||:.||
Mosquito   479 NRMAFIMWFSGLRGAISYALSLHMQFSTEESRHVVITTTLIIVLFTTLFFGGSTMPLMKYLQGGK 543

  Fly   519 K-RRARGSGRNAAEEGGRRNGSGRKR-SKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQAR-D 580
            | :|...:||           :|||| .|::||||||||||||||||||||||||:|:|||:| .
Mosquito   544 KVKRTARAGR-----------AGRKRKEKALSLSKTREWGQAIDSEHLSELTEEEEVSFTQSRIG 597

  Fly   581 RFGRMDRKYFIPFFTRRFNSQELHECKSQMADLTNKWYQAIRVSPLDSDESDEE 634
            .|.|.|||:|.|||||||..||||:|||||||||||||||||:||.|.||.||:
Mosquito   598 GFTRWDRKFFTPFFTRRFTHQELHDCKSQMADLTNKWYQAIRISPDDPDEEDED 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	392/489 (80%)
Nhe1	XP_061515684.1	None