Protein Alignment Nhe1 and slc9a6

DIOPT Version :10

• Sequence 1: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_002932638.3
• Gene: slc9a6 / 100497414
• XenbaseID: XB-GENE-6048314
• Length: 707
• Species: Xenopus tropicalis
• Alignment Length: 682
• Identity: 213/682 - (31%)
• Similarity: 327/682 - (47%)
• Gaps: 120/682 - (17%)

  Fly    38 TTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTT----------KRGNASTLVTDPPLIDSH 92
            ||..:..:..|.|...|.:||..:.|  .:.|..:.|          .|..|...|.: .::...
 Frog    10 TTLSHDPARITGSPAPVMAPLVAMKP--GSRGRKAWTMLLLLLALALDRAGAQDSVIE-EIVTEK 71

  Fly    93 AVEQEH-NSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSL---------- 146
            .||..| ..|.:|...|.::.|.||.|.......|::|.|:.:.:..|...|:.|
 Frog    72 QVEASHRQDSANLLVFILLLTLTILTIWLFKHRRFRFLHETGLAMIYGLIAGVVLRYGIHVPSDV 136

  Fly   147 -NV----------------MSG-------------------QNGSWKREEVFSPMGFFLVLLPPI 175
             ||                :||                   |:....|:..|....||.:|||||
 Frog   137 NNVTMSCELQTSPATLLVNVSGKFYEYMLKGEISSKALNNVQDNDMLRKVTFDTEVFFNILLPPI 201

  Fly   176 IFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-LLGLGEVAFRLS----FSESFAFG 235
            ||.:||:|.:.:||:|:||||.:|..||.||.|||||.:| .:.|.:|...|.    |::...||
 Frog   202 IFYAGYSLKRRHFFRNMGSILAYAFLGTAISCLVIGALLYGCVKLMKVTGTLDGDFYFTDCLFFG 266

  Fly   236 SLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASIT--QSANVNAEASTGEAMF 298
            ::|||.|||..:||||.|.||..|..|:||||:||||::|||::||.  |.|..|:......|||
 Frog   267 AIISATDPVTVLAIFHELHVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDITAMF 331

  Fly   299 SALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMA 363
            ..:..|..:|..|..:|....::::|:.|...||:.|.||..:..:.:::.::|||....:|::|
 Frog   332 KCIGMFLGIFSGSFAMGAATGVVTSLVTKFTKLREFPLLETGLFFLMSWSTFLLAEACGYTGVVA 396

  Fly   364 ILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFK-HQVELSFVIWAIV 427
            :|||||..:|||:.||||.:|...:|....|.|:||..:|:|:|||:|:|: |....:|::.|.:
 Frog   397 VLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLALFTFQNHVFNPTFIVGAFL 461

  Fly   428 LCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLDSQE-KRHVIITT 491
            ...:|||.||:||:||:|..|::||.:..|.:|.|:|||||:::||::.   |:.. .|.::.:|
 Frog   462 AVFLGRAANIYPLSFLLNLGRKNKIGSNFQHMMMFAGLRGAMAFALAIR---DTATYARQMMFST 523

  Fly   492 TLIIVLFTTLVLGGSTMPLLK--YLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSKSISLSKTRE 554
            ||:||.||..|.||.|..:|.  :::.|.....   .:.|..|..||:      :|:.|....|.
 Frog   524 TLLIVFFTVWVFGGGTTAMLSCMHIRVGVDSEI---DQMAIPENERRS------TKAESAWIFRL 579

  Fly   555 WGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPF----FTRRFNSQELHECKSQMADLTN 615
            | ...|..:|..|........|..            :|.    ..|...|.:.:|.:.|:.|
 Frog   580 W-YNFDHNYLKPLLTHSGPPLTAT------------LPSCCGPLARCLTSPQAYENQEQLKD--- 628

  Fly   616 KWYQAIRVSPLDSDESDEEIGLAASTSQIHLT 647
                         |:||    |..:...|.||
 Frog   629 -------------DDSD----LILNDGDISLT 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	182/546 (33%)
slc9a6	XP_002932638.3	Na_H_Exchanger	186..593	CDD:470090	164/419 (39%)