DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11377 and CRELD2

DIOPT Version :9

Sequence 1:	NP_608490.1	Gene:	CG11377 / 33166	FlyBaseID:	FBgn0031217	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_005261794.1	Gene:	CRELD2 / 79174	HGNCID:	28150	Length:	403	Species:	Homo sapiens

Alignment Length:	349	Identity:	126/349 - (36%)
Similarity:	173/349 - (49%)	Gaps:	68/349 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PPPCRACTQLVSSFRAGL-ERTKRGHAGGDTAWEEEKLRSYKNSEVRLVEIQEKLCSEGEVINKD 91
            |.||..|..||..|..|: :..|:...||:|||||:.|..|::||:||:||.|.||...:.
Human    28 PTPCHRCRGLVDKFNQGMVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEILEGLCESSDF---- 88

  Fly    92 HCHNLANEHEALLEDWFIHKQTESPDLQSWLCIDQLTVCCPLNTYGPDCLTC-----TECNGNGK 151
            .|:.:....|..||.|::..::|.|||..|.|:..|.|||...|||||||.|     ..|:|||.
Human    89 ECNQMLEAQEEHLEAWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGH 153

  Fly   152 CKGDGTRKGNGKCKCDPGYAGPNCNECGPEHYESFRDEKKLLCTQ-----------------C-- 197
            |.|||:|:|:|.|:|..||.||.|.:|...::.|.|:|...:||.                 |
Human   154 CSGDGSRQGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTAVRTGLSDSYPPCCLSLGCWR 218

  Fly   198 ---HA------------------------ACGEG--GCTGGGPKSCRKCKKGWSMDSEAGCVDIN 233
               ||                        ||.|.  .|:|...:.|.:|:.||.:| |..|||::
Human   219 GVGHAWIRGRNTHTQPGYSSRVWIAAFSPACDESCKTCSGLTNRDCGECEVGWVLD-EGACVDVD 282

  Fly   234 ECLEQQRPNPCRPQQFCVNNEGSFSCLECDRSCDGCDGDGPDMCRKCADGYELKEGKCHDIS--- 295
            ||..:  |.||...|||.|..||::|.|||.||.||.|:||..|::|..||..:.|:|.|:.
Human   283 ECAAE--PPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKECISGYAREHGQCADVDECS 345

  Fly   296 -AEQ---RSNYVSFTRMLTYFGMC 315
             ||:   |.|...:....:|..:|
Human   346 LAEKTCVRKNENCYNTPGSYVCVC 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11377	NP_608490.1	DUF3456	31..123	CDD:288766	35/92 (38%)
		EGF_CA	231..>259	CDD:214542	12/27 (44%)
		FU	258..293	CDD:214589	17/34 (50%)
CRELD2	XP_005261794.1	DUF3456	31..120	CDD:371810	35/92 (38%)
		FU	247..280	CDD:214589	12/33 (36%)
		FU	305..345	CDD:214589	18/39 (46%)
		vWFA	<338..378	CDD:381780	8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3406
eggNOG	1	0.900	-	-		E1_KOG4260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11526
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3022
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45808
OrthoDB	1	1.010	-	-		D378427at33208
OrthoFinder	1	1.000	-	-		FOG0002526
OrthoInspector	1	1.000	-	-		otm41471
orthoMCL	1	0.900	-	-		OOG6_105894
Panther	1	1.100	-	-	LDO	PTHR24034
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1897
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840