DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11377 and creld1

DIOPT Version :9

Sequence 1:	NP_608490.1	Gene:	CG11377 / 33166	FlyBaseID:	FBgn0031217	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	XP_009302639.1	Gene:	creld1 / 569741	-ID:	-	Length:	400	Species:	Danio rerio

Alignment Length:	412	Identity:	148/412 - (35%)
Similarity:	199/412 - (48%)	Gaps:	86/412 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YC-WLATLVFIAAASASYSPEKPVPPPCRACTQLVSSFRAGLERT-KRGHAGGDTAWEEEKLRSY 67
            :| ||  |:|      |.|.|......|:.|.:|..||..||||| .:...||:||||||||..|
Zfish     2 WCVWL--LLF------SLSVETLSSSSCQTCRKLSHSFIKGLERTANKNFGGGNTAWEEEKLAKY 58

  Fly    68 KNSEVRLVEIQEKLCSEGEVINKDHCHNLANEHEALLEDWFIHKQTESPDLQSWLCIDQLTVCCP 132
            ..||.||:||.|..|.:.:.    .|:.|..:.|..:|.|:.|:|.|:|||..||||::|.:|||
Zfish    59 ARSETRLLEIVEAACDKSDF----ECNRLLEQIEDQVETWWFHRQQEAPDLFEWLCIEELRLCCP 119

  Fly   133 LNTYGPDCLTCTE-----CNGNGKCKGDGTRKGNGKCKCDPGYAGPNCNECGPEHY-ESFRDEKK 191
            ...|||.|..|..     |.|.|:|:|:|||.|:|.|.|||||||..|.||...:| |...:..:
Zfish   120 AGHYGPQCAECPSGPAGVCGGLGRCEGEGTRLGDGDCVCDPGYAGVLCQECADGYYREKSSNHTQ 184

  Fly   192 LLCTQCHAACGEGGCTGGGPKSCRKCKKGWSMDSEAGCVDINEC-LEQQRPNPCRPQQFCVNNEG 255
            ..|:.||.:|..  |:|...|.|:.||.||.:.| :.|:|::|| .|..|   |....:|.|.:|
Zfish   185 PPCSACHHSCKV--CSGPLEKQCQLCKSGWILHS-SRCIDVDECGTELAR---CPSNTYCFNTDG 243

  Fly   256 SFSCLECDRSCDGCDGDGPDMCRKCADGYELKEGKCHDIS----------------AEQRSNY-- 302
            |:.|..||::|.||.|.||..|:|||.|:.|...||.||.                ..:..:|
Zfish   244 SYECRGCDQACVGCMGSGPARCKKCARGFRLTGAKCLDIDECLERTIACPGLNEACVNEEGSYRC 308

  Fly   303 ---VSFTRM-------LT-----------------------YFGMCVATCVIFQSSTHIAWGCIV 334
               ..|.|.       ||                       :||  |..|.:   :|..|.|.:|
Zfish   309 ECADGFIRRDSICVENLTPAGPEKGLFDDMTDDEVLVLQQMFFG--VVICAL---ATLAAKGDMV 368

  Fly   335 GAA--VAGYIAVSEYWINSEAG 354
            ..|  :.|..|::.||: ||.|
Zfish   369 FTAIFIGGVAAMAGYWL-SEKG 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11377	NP_608490.1	DUF3456	31..123	CDD:288766	41/92 (45%)
		EGF_CA	231..>259	CDD:214542	10/28 (36%)
		FU	258..293	CDD:214589	17/34 (50%)
creld1	XP_009302639.1	DUF3456	21..110	CDD:288766	41/92 (45%)
		FU	187..237	CDD:214589	20/55 (36%)
		EGF_CA	281..>314	CDD:304395	3/32 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2811
OMA	1	1.010	-	-		QHG45808
OrthoDB	1	1.010	-	-		D378427at33208
OrthoFinder	1	1.000	-	-		FOG0002526
OrthoInspector	1	1.000	-	-		otm25017
orthoMCL	1	0.900	-	-		OOG6_105894
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2992
SonicParanoid	1	1.000	-	-		X1897
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770