DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11377 and creld2

DIOPT Version :9

Sequence 1:	NP_608490.1	Gene:	CG11377 / 33166	FlyBaseID:	FBgn0031217	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_956817.1	Gene:	creld2 / 393495	ZFINID:	ZDB-GENE-040426-1626	Length:	341	Species:	Danio rerio

Alignment Length:	270	Identity:	128/270 - (47%)
Similarity:	165/270 - (61%)	Gaps:	14/270 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CRACTQLVSSFRAGLERT-KRGHAGGDTAWEEEKLRSYKNSEVRLVEIQEKLCSEGEVINKDHCH 94
            |..|.|||..|..|||:| |:...||:|||||.||..|:.||:||.|..|.||.....    .|.
Zfish    31 CSTCRQLVDDFDKGLEKTAKQNFGGGNTAWEERKLSKYETSEIRLTETLEGLCQSSNF----ECS 91

  Fly    95 NLANEHEALLEDWFIHKQTESPDLQSWLCIDQLTVCCPLNTYGPDCLTC-----TECNGNGKCKG 154
            ::..|:|..||.|:..::|:.|||..|.||:.:.||||..::||||.||     ..|:|||||.|
Zfish    92 HMLEENEEHLEAWWFKRKTKHPDLFKWFCIETIKVCCPKGSFGPDCNTCIGGADRPCHGNGKCDG 156

  Fly   155 DGTRKGNGKCKCDPGYAGPNCNECGPEHYESFRDEKKLLCTQCHAACGEGGCTGGGPKSCRKCKK 219
            ||||.|||||.||.||.|..|.:|...::.|.|::...||.:||.:|  .||:||..:.|::|:.
Zfish   157 DGTRAGNGKCSCDEGYDGEFCLDCSDGYFNSLRNDTFSLCKECHESC--VGCSGGTNQHCKECRN 219

  Fly   220 GWSMDSEAGCVDINECLEQQRPNPCRPQQFCVNNEGSFSCLECDRSCDGCDGDGPDMCRKCADGY 284
            ||..|.|..|:|||||::.  |.||...|:|:|.:|||||..||..|.||.|||...|..|||||
Zfish   220 GWVKDQEGSCIDINECIKD--PAPCSDDQYCLNTDGSFSCKACDIRCTGCKGDGASSCLNCADGY 282

  Fly   285 ELKEGKCHDI 294
            :.:||.|.||
Zfish   283 KDEEGTCTDI 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11377	NP_608490.1	DUF3456	31..123	CDD:288766	40/92 (43%)
		EGF_CA	231..>259	CDD:214542	14/27 (52%)
		FU	258..293	CDD:214589	19/34 (56%)
creld2	NP_956817.1	DUF3456	31..120	CDD:288766	40/92 (43%)
		FU 1	193..248		25/58 (43%)
		FU	194..>225	CDD:214589	13/32 (41%)
		FU 2	254..308		23/39 (59%)
		EGF_CA	291..>317	CDD:304395	2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11526
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2811
OMA	1	1.010	-	-		QHG45808
OrthoDB	1	1.010	-	-		D378427at33208
OrthoFinder	1	1.000	-	-		FOG0002526
OrthoInspector	1	1.000	-	-		otm25017
orthoMCL	1	0.900	-	-		OOG6_105894
Panther	1	1.100	-	-	LDO	PTHR24034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2992
SonicParanoid	1	1.000	-	-		X1897
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870