DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11377 and mec-9

DIOPT Version :9

Sequence 1:	NP_608490.1	Gene:	CG11377 / 33166	FlyBaseID:	FBgn0031217	Length:	374	Species:	Drosophila melanogaster
Sequence 2:	NP_001256153.1	Gene:	mec-9 / 179382	WormBaseID:	WBGene00003173	Length:	838	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	102/463 - (22%)
Similarity:	154/463 - (33%)	Gaps:	170/463 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVFIAAASASYSP-----------EKPVPPPCRACTQLVSSFRAGLERTKRGHAGGDTAWE---E 61
            |||:........|           |...|.||: ..|:...:...:|..|..|.||....:   .
Worm    14 LVFLNLVDTKDEPVFVKNNEDICLEDVDPGPCQ-YYQVQWFWDKQVEECKEFHYGGCMGTKNRFS 77

  Fly    62 EKLRSYKNSEVRL---VEIQEKLCSEGEVINKD--HCHNLANEHEALLEDWFIHKQTESPDLQSW 121
            .|.:..|..:.::   |.:.: ||    :::.|  ||.:..|.|      |:.....||.:.:.:
Worm    78 SKQQCVKQCKYKMFNPVAVPD-LC----LLDADQGHCGDERNGH------WWYFFNQESGECEKF 131

  Fly   122 --------------------LCIDQLT---VC--CPL-----------------------NTYGP 138
                                :|.::|:   .|  |.|                       |.||
Worm   132 FYYGCGGNDNKFYSLHMCRKVCGERLSPQIACDHCDLRTSFCKSNSKFNYTCECRSGYEKNQYG- 195

  Fly   139 DCLTCTECNG-------NGKCKGDGTRKGNGKCKCDPGYA--GPNCNECGPEHYESFRDEKKLLC 194
            :|:...||.|       |..|..:   .|:.||:|...|.  |.:|...|       .....:.|
Worm   196 ECIDIDECRGYKAVCDRNAWCVNE---IGSYKCECMASYRGDGKHCTYVG-------LGRSSIDC 250

  Fly   195 TQC--HAACGEGGCTGGGPKSCRKCKKGWSMDSEAGCVDINECLEQQRPNPCRPQQFCVNNEGSF 257
            ..|  ||.|..|.|         :||:|:..|. ..|.|:||||  :||..|.....|:|.||||
Worm   251 KDCSMHATCMNGVC---------QCKEGYEGDG-FNCTDVNECL--RRPEMCNKNAECINREGSF 303

  Fly   258 --SCLE--------CDRSCDGC----DGDGPDMC---------------RKCAD-GYELKEGKCH 292
              :|||        |..|.:.|    |.|..|.|               |.|.. .|:...|:..
Worm   304 ICTCLEGYAGNGYNCTVSKNSCLDKFDHDYKDTCGNENWRPHFFFNHQTRMCEQFWYDGCRGRSR 368

  Fly   293 DISAEQRSNYVSFTRMLTYFGMCVATCVIFQSSTHIAWG---------CIVGAAVAGY------I 342
            :|.:|    |.:.|.      ||..|.|:  :...:.|.         |:.|.....|      :
Worm   369 NIFSE----YDTCTT------MCEETNVL--TRAEVCWDKFDMNYRNQCMNGQWQQRYYFDHASL 421

  Fly   343 AVSEYWIN 350
            ...::|.:
Worm   422 TCRQFWFD 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11377	NP_608490.1	DUF3456	31..123	CDD:288766	20/119 (17%)
		EGF_CA	231..>259	CDD:214542	14/29 (48%)
		FU	258..293	CDD:214589	14/62 (23%)
mec-9	NP_001256153.1	Kunitz_BPTI	35..87	CDD:278443	12/52 (23%)
		Kunitz_BPTI	100..154	CDD:278443	9/63 (14%)
		EGF_CA	199..238	CDD:284955	11/41 (27%)
		EGF_3	283..318	CDD:289699	14/36 (39%)
		KU	323..381	CDD:197529	13/67 (19%)
		KU	<408..449	CDD:197529	3/22 (14%)
		KU	460..516	CDD:197529
		EGF_CA	550..586	CDD:238011
		EGF	639..671	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4707
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950