Protein Alignment Zir and DOCK4

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_016868308.1
• Gene: DOCK4 / 9732
• HGNCID: 19192
• Length: 2006
• Species: Homo sapiens
• Alignment Length: 2065
• Identity: 384/2065 - (18%)
• Similarity: 689/2065 - (33%)
• Gaps: 735/2065 - (35%)

  Fly   159 FEEAFAYKSESCTPSSRQSIASLAS----VSSCTDTLTPRGS-WAS------------------- 199
            |..::.:...:|..:..|....:.:    ::..|.||...|: |..
Human    88 FPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNE 152

  Fly   200 -FDLRRSVNDPLIPNLLDNVPPE---HI----DQSNEARRQQDRQMALFSLYPESE----AEENI 252
             .||||.|   |:.:|..:...:   ||    |..||       |:.| .|.|..|    ..|:|
Human   153 ILDLRRQV---LVGHLTHDRMKDVKRHITARLDWGNE-------QLGL-DLVPRKEYAMVDPEDI 206

  Fly   253 ----------ERRLLAEIPVEHMGHRIQVN-----CLQLRLELEVEPIFASMAIYDAKERQKISE 302
                      .|....:.||:...|.:.|.     |..|..||||  ||   :::|:||.:.|||
Human   207 SITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEV--IF---SLFDSKENRPISE 266

  Fly   303 NFYFDMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSN----DLFL---VIRLEKVLQGDINN 360
            .|:..:|.:.|.:        |....:.|.::| :...|:    |:::   :||:.::..|:
Human   267 RFFLRLNRNGLPK--------APDKPERHCSLF-VDLGSSELRKDIYITVHIIRIGRMGAGE--- 319

  Fly   361 SVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGD------------NFES 413
                             |.||...     :||.||....:.:.::..|:            |.||
Human   320 -----------------KKNACSV-----QYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTES 362

  Fly   414 KDAGAAER-----DSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERK 473
            :.....|.     ::..|..||:.|.|.|...|.     ...:|:||   :.|...:...|:.||
Human   363 EWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLH-----GDIEQIRR---EYSSVFSHGVSITRK 419

  Fly   474 EKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSI 538
            .        .|:|::                                             :||.:
Human   420 L--------GFSNII---------------------------------------------MPGEM 431

  Fly   539 KLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFS 603
                                                               ||.|:::.:...|.
Human   432 ---------------------------------------------------RNDLYITIERGEFE 445

  Fly   604 SRAGS-ARNIAVRVQLM--AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIAL 665
            ....| |||:.|.:.::  :|:|.||.::  :|....|  ::|..:.|.|||..|.:.:.:|:.:
Human   446 KGGKSVARNVEVTMFIVDSSGQTLKDFIS--FGSGEPP--ASEYHSFVLYHNNSPRWSELLKLPI 506

  Fly   666 PASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLL-EDGKLKFGEFNLP-----VMVE 724
            |....:..|:.|...|.|.::|.:      :...|::::||: |||:      .||     ::|.
Human   507 PVDKFRGAHIRFEFRHCSTKEKGE------KKLFGFSFVPLMQEDGR------TLPDGTHELIVH 559

  Fly   725 SPPENYSFIPPNVHLPGIKWLDNHRAVF-SINVEAVTAIHTLDSFLDRFFLIC--------EYLD 780
            ...||.:......:|.    |...:.:| ..|.:|:.|  |.:||....|| |        :.||
Human   560 KCEENTNLQDTTRYLK----LPFSKGIFLGNNNQAMKA--TKESFCITSFL-CSTKLTQNGDMLD 617

  Fly   781 TRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVF 845
            .....:|      ..::..||..::..:...:|:.|...||.|..:|      ...:...||.||
Human   618 LLKWRTH------PDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGIL------DENSQKYGSKVF 670

  Fly   846 EVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDL-QLSES 907
            :.|.   .::::|.|.::..:  :.::.||:  ||...:.:               .|| ::.:.
Human   671 DSLV---HIINLLQDSKFHHF--KPVMDTYIESHFAGALAY---------------RDLIKVLKW 715

  Fly   908 YTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFE 972
            |.  |.:..:    :|:|            .:|..|..:|....::|.|.:...||...
Human   716 YV--DRITEA----ERQE------------HIQEVLKAQEYIFKYIVQSRRLFSLATGG------ 756

  Fly   973 LIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFI 1037
                                      |..::....:..:...|..:.|.|.|.:.:|:.|...|:
Human   757 --------------------------QNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFL 795

  Fly  1038 FDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVT 1102
            ....::            |:::|  |...:.::.|...|.|
Human   796 SSFPAV------------YSELL--KLFDVREVANLVQDTL------------------------ 822

  Fly  1103 APCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRC 1167
                              |||...||.|.|.:.::                           ::|
Human   823 ------------------GSLPTILHVDDSLQAIK---------------------------LQC 842

  Fly  1168 IRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQ 1232
            |...:.|.    .|:..|:|      || ||.:|:.   .||.|..||..|
Human   843 IGKTVESQ----LYTNPDSR------YI-LLPVVLH---HLHIHLQEQKDL-------------- 879

  Fly  1233 TITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDL 1297
             |..:.|...|...|.            ||    |||.:         ||:.::  |:...|:|
Human   880 -IMCARILSNVFCLIK------------KN----SSEKS---------VLEEID--VIVASLLD- 915

  Fly  1298 SPHRVHQMLQGVNVCLKT-FEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDL 1361
                         :.|:| .|.|.:...::       |..:....||..:...|:       ..|
Human   916 -------------ILLRTILEITSRPQPSS-------SAMRFQFQDVTGEFVACL-------LSL 953

  Fly  1362 INRRKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIV-- 1424
            :.:..||              :..|..|:....|   ||..|:         |.:.....|::
Human   954 LRQMTDR--------------HYQQLLDSFNTKE---ELRDFL---------LQIFTVFRILIRP 992

  Fly  1425 ----------HAAANLYHNLLGTVLKVLLHSLSRN-----------QSVLALQNLFASQRALIFK 1468
                      ...||   |::.|.:..|..:|.:|           .|...|..:|.:|..|..:
Human   993 EMFPKDWTVMRLVAN---NVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLE 1054

  Fly  1469 F-----PNLLFDDETDICADL-CLI------LLKH--------CGSLL-------PGIRSQAAAS 1506
            .     ...:.:...|:...: |.|      |.:|        .|..|       |.:|:.....
Human  1055 MFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPI 1119

  Fly  1507 LYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVL----VYAESDSDLQDT 1567
            .:.:|........||.:|:.::...|.||:....  .:::.|....:::    .|......::..
Human  1120 FHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGK--GDETYRELFNSIIPLFGPYPSLLKKIERE 1182

  Fly  1568 SFPEQVQDLLFNLHMILS------DTVKMKEYQEDPEML---LDLMNRIAKGYQNNPDLRLTWLE 1623
            ::.|....|:..:..::.      |.:||.|.  |.:.:   :.|:| ..|...|..::.:.::.
Human  1183 TWRESGVSLIATVTRLMERLLDYRDCMKMGEV--DGKKIGCTVSLLN-FYKTELNKEEMYIRYIH 1244

  Fly  1624 NMAKKHRERANHTEAAMCYVHAASLVS-------EYLSM-----LESQKHLPVGAV-SFQRISPN 1675
            .:...|.:..|.||||...:....|:.       |:|:.     .:.::||.:..: :|.|
Human  1245 KLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDR---- 1305

  Fly  1676 TLMESAVSDDVLSPG---EDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICE 1737
                          |   |:||.|..                  ::|..||:.
Human  1306 --------------GKCWENGIILCR------------------KIAEQYESY------------ 1326

  Fly  1738 ANRDFQKLSKVHGKLQEA--FNRISQLQGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLTKL 1799
              .|::.|||:  ::.||  :::|...|  |:...:|||||||.||. .|..:||:.:.....:|
Human  1327 --YDYRNLSKM--RMMEASLYDKIMDQQ--RLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERL 1385

  Fly  1800 PEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRE------ 1858
            .....|:.|.:     |.:: .::.:|..|......:..|:||..|.|..|:.|:..||
Human  1386 EAFQQRMLNEF-----PHAI-AMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNI 1444

  Fly  1859 -TYFERNFNIKRFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEP 1921
             ::::.| :|.:|.|..||.|..| ...|.......:|.|......|.:.....|..|:.:.:.|
Human  1445 KSFYKVN-HIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSP 1508

  Fly  1922 IEVAIEDIQKKTLELAAATNQ------EPADPKILQMVLQGCIGTTVNQGPMEMASVF------L 1974
            :|.|||.::.|..:|....:|      :..:|  |.|.|.|.|...||.|.......|      |
Human  1509 LENAIEVLENKNQQLKTLISQCQTRQMQNINP--LTMCLNGVIDAAVNGGVSRYQEAFFVKEYIL 1571

  Fly  1975 SNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQREL 2024
            |:..||..:.     :||....|.::.....|..:...:..|.:...::|
Human  1572 SHPEDGEKIA-----RLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKL 1616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	47/189 (25%)
		DHR-2	1549..2037	CDD:284365	111/528 (21%)
DOCK4	XP_016868308.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740