DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Zir and DOCK7

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:NP_001354490.1 Gene:DOCK7 / 85440 HGNCID:19190 Length:2140 Species:Homo sapiens


Alignment Length:2187 Identity:1045/2187 - (47%)
Similarity:1429/2187 - (65%) Gaps:233/2187 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QRSFVQKVSKQSAADVRKNVSGCH-----LSKAMDPSLCG-----SSISPTE---PLDYEEFLSQ 56
            :|:|.||:|:..||:|||.:||.:     |.|.:  ::.|     :::..||   |:|.|::|..
Human     4 RRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNL--NIVGNISHHTTVPLTEAVDPVDLEDYLIT 66

  Fly    57 HMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEY 121
            |...::..||:.:::||..|:.|...||..||:...||.|  |::..||::|:..||..|.:|  
Human    67 HPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEE--SEMDPHVRDCIRSYTEDWAIV-- 127

  Fly   122 AQRHLSSSCYIRERIDRGT-ISPSAYQQEFEIDKD-----FSSFE--EAFAYKSESCTPSSRQSI 178
                      ||:....|| .:|:...::.|..|.     |.|.|  :..:|:.:. ....|:|:
Human   128 ----------IRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQ-DDLKRRSM 181

  Fly   179 ASLASVSSCTDTLTPRGSWAS--FDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFS 241
                   |..|  |||||||.  |||:.|:.|.|:|||||..|.|.||:.|:.:|:.:|...||:
Human   182 -------SIDD--TPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFA 237

  Fly   242 LYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYF 306
            |:|..:.||.|||..:.:||.||.|.|:.|.||.|:.|:|:||||||:|:||.||::||||||||
Human   238 LHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYF 302

  Fly   307 DMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPYL--KE 368
            |:|::.:|.:|..||..|.|:|.:.||||.|:|||.|:||||:||||| ||||....|||:  ||
Human   303 DLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKE 367

  Fly   369 -----DKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNAC 428
                 :|:|. ||:||.|..:|:||||||||||||.|:|.|:.:       .||:.||||     
Human   368 ADATKNKEKL-EKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVS-------SAGSLERDS----- 419

  Fly   429 GSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRP 493
                 |....::.:||.|.|.    ||     :.::..|.|||     |:.|.||..|:. :|||
Human   420 -----TEVEISTGERKGSWSE----RR-----NSSIVGRRSLE-----RTTSGDDACNLT-SFRP 464

  Fly   494 ITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELA 558
            .|:||.:|||||.|::.||||||.|.:::|||||:::.:.|...:|::|||..|.....|||||.
Human   465 ATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELL 529

  Fly   559 PINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGET 623
            .:.......|||.:||||||...:|.|:.:|||||::.|:.|||::|.||||||.|:||.|.||.
Human   530 QVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGED 594

  Fly   624 PKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKP 688
            |.:|:..|:|||||.:||.||:|||.|||:.|.|::|||:.|||::..|||||||.||||||:|.
Human   595 PSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQ 659

  Fly   689 QDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFS 753
               ...:|||:||||:|:|::|:||.|:|.|||.:|.||:.||.:.|.|.|||:||:|||:.||:
Human   660 ---NTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFN 721

  Fly   754 INVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIG-----ENNIETELKKCLLDIEYANREPLV 813
            :.|.||::|||.|.:||:||.:...||....|..||     |||:|.|||..:..:..:..||:|
Human   722 VEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQLEPVV 786

  Fly   814 RHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHF 878
            |.|.|:|||||.|::....:.||.::||...||.:..:.:.|....:..:||:||.|||::|:|:
Human   787 RFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNSLLASYIHY 851

  Fly   879 QCKIPHPFQ------------SKQRLTCSRSTTE--DLQLSESYTIY--------------DNV- 914
            ..::|:.:.            |....|.:||...  .|.|:.|.::.              |.| 
Human   852 VFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVR 916

  Fly   915 -LASGRSLDRKELSIDV--------------------------------------LHSMAARDVQ 940
             :...:.|||....::.                                      |.::..|...
Human   917 SIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPT 981

  Fly   941 VRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLS 1005
            .:|.||||||.|||.||...:.|:..:||.|||:||||:.||:.::.|..|||.|||.:|.||::
Human   982 KKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLEAPRKSRFPERFMDDIA 1046

  Fly  1006 TLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPD- 1069
            .||..:.:.:|.....:.::.:.||.||.||:.|:||:|||||||.|||:..|.:.||..|:|: 
Human  1047 ALVSTIASDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLIKSCYKQVSSKLYSLPNP 1111

  Fly  1070 --LMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSL-----ERAL 1127
              |::.::|||||:|||||:|.||||    .:::|.|.||:||.:|:.||:|..|.     :.|.
Human  1112 SVLVSLRLDFLRIICSHEHYVTLNLP----CSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIAN 1172

  Fly  1128 HADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQ----LHGKAIRCIRNLMTSHDLDARYSETDARA 1188
            ..:||..|.|||:|.||||::||.::: |:.:    ||.|.|..:.||::|||.|.|||:...:|
Human  1173 MFELSVPFRQQHYLAGLVLTELAVILD-PDAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKA 1236

  Fly  1189 RVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQ-----LEDYQGPHQTITASTINPEVAFAIS 1248
            |||.||:||:.|:|:.:|||:..   .:...|.|:     .:||:..    :.|.|:..||.||:
Human  1237 RVAMLYLPLIGIIMETVPQLYDF---TETHNQRGRPICIATDDYESE----SGSMISQTVAMAIA 1294

  Fly  1249 G------SRPYSYL--NEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQM 1305
            |      :||.|:|  :...:.....|:|::|.||:|.||||||.:..||.:|..|||..:::::
Human  1295 GTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRL 1359

  Fly  1306 LQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDR-- 1368
            |..:.:|:..|||.|:|   ..:|.|:.:|:|  |.|::.||||.|.|:..||.:::.|.:.:  
Human  1360 LDLLYLCVSCFEYKGKK---VFERMNSLTFKK--SKDMRAKLEEAILGSIGARQEMVRRSRGQLG 1419

  Fly  1369 -----------------NSTEKFRWRKDQMPYRSQYADAVGKSEHELELSHFIEGSLATEVALVL 1416
                             .|.|..|||||...:| |..:.:.||..|:|....|:|:||||..|::
Human  1420 TYTIASPPERSPSGSAFGSQENLRWRKDMTHWR-QNTEKLDKSRAEIEHEALIDGNLATEANLII 1483

  Fly  1417 LDTLEIIVH--AAANLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETD 1479
            ||||||:|.  :......::||.||||||||::.|||.:.||:.||:||||:.|||.|||::||:
Human  1484 LDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETE 1548

  Fly  1480 ICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSE 1544
            .||||||.||:||.|.:..|||.|:|||||||||||||||||||||||||||||||||||..|:|
Human  1549 QCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNE 1613

  Fly  1545 QSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAK 1609
            :.|||:|||:|.|||.|.:|::|:||:|||||:|||||||||||||||:|||||||:|||.||||
Human  1614 EFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAK 1678

  Fly  1610 GYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISP 1674
            |||.:||||||||:|||.||.||:||.|||.|.||:|:||:|||||||.:|:||||.|:||.||.
Human  1679 GYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQNISS 1743

  Fly  1675 NTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEAN 1739
            |.|.||||||||:||.|:|||.|.:|||:||..|||:|:.||.:||||||:|||||:||||.|||
Human  1744 NVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEAN 1808

  Fly  1740 RDFQKLSKVHGKLQEAFNRI-SQLQG-KRVFGTYFRVGFYGGKFGDLDQQEFIYKEPTLTKLPEI 1802
            ||.:|||.:||||||||::| .|..| :|:|||||||||||.||||||:|||:||||.:|||.||
Human  1809 RDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEI 1873

  Fly  1803 FSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNI 1867
            ..||:.||.||||.|.|.:|||||.||...|||:|||||||||||||:||||:.|.|||::|:|:
Human  1874 SHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNL 1938

  Fly  1868 KRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKK 1932
            :||:|.||||.:|:|||||:||.||||||||::.|||:|||:.|..:::|:|.||||||||:|||
Human  1939 RRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKK 2003

  Fly  1933 TLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFRE 1997
            |.|||.||:|:|||||:|||||||.:||||||||:|:|.||||.:.....: .:|.|||||||::
Human  2004 TQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKL-FRHHNKLRLCFKD 2067

  Fly  1998 FSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFI 2039
            |:|||.|||:||::||..|||:||||||||..|..|.|.|.|
Human  2068 FTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLI 2109

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 26/92 (28%)
C2_Dock-C 589..769 CDD:176078 103/179 (58%)
DHR-2 1549..2037 CDD:284365 337/489 (69%)
DOCK7NP_001354490.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..183 9/52 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 888..971 8/82 (10%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149367
Domainoid 1 1.000 745 1.000 Domainoid score I95
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H23566
Inparanoid 1 1.050 1862 1.000 Inparanoid score I60
Isobase 1 0.950 - 0 Normalized mean entropy S4471
OMA 1 1.010 - - QHG55633
OrthoDB 1 1.010 - - D14993at33208
OrthoFinder 1 1.000 - - FOG0000340
OrthoInspector 1 1.000 - - otm41825
orthoMCL 1 0.900 - - OOG6_100358
Panther 1 1.100 - - O PTHR23317
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5567
SonicParanoid 1 1.000 - - X255
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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