Protein Alignment Zir and DOCK7

DIOPT Version :10

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_001354490.1
• Gene: DOCK7 / 85440
• HGNCID: 19190
• Length: 2140
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 61/320 - (19%)
• Similarity: 94/320 - (29%)
• Gaps: 136/320 - (42%)

  Fly   101 SSVVKDVSSLSIDIEHDVRRDAYKTLGC-----------------------ILAACGQSVMVPFY 142
            |.:|..|..|::....|     |.|..|                       :||:.  .|:|...
Human    75 SEIVSSVLVLNLTNAED-----YGTFTCSVWNVSSHSFTLWRAGPAGHVAAVLASL--LVLVVLL 132

  Fly   143 EVLLSFLRCSMTHI------QSRIQEDSLLLLDVLLQY--LPE--------------------LV 179
            .|.|.:::|.:..:      ...::.:...|.|..:.|  .||                    |.
Human   133 LVALLYVKCRLNMLLWYQDTYGEVEMNDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLF 197

  Fly   180 VANRDKILPQFLDMISKLRTESKPGRTLTINLDKQSTSTRWRVKVLSRIMLHAPTTWFASKVPD- 243
            :.:|| :||:           ::|...|.:||.:    .|..:.|||...|..|  |.:....:
Human   198 LEDRD-LLPR-----------AEPSADLLVNLSR----CRRLIVVLSDAFLSRP--WCSQSFREG 244

  Fly   244 -----YQPDKAVQINYTFDRASTMFLPI--------QKRHLYT---------------------T 274
                 ....:.:.|.:...|..    ||        |.|||.|                     .
Human   245 LCRLLELTRRPIFITFEGQRRE----PIHPALRLLRQHRHLVTLVLWKPGSVTPSSDFWKELQLA 305

  Fly   275 CPMDVLFRKTTG-------TDKD--LSLGDRVDDGRKLKMYVEMLMPVLFESWLEVRPTG 325
            .|..|.:|...|       .|||  |.:..|...||.:            ||.|:..|.|
Human   306 LPRKVQYRPVEGDPQTRLQDDKDPMLIVRGRAAQGRGM------------ESELDPDPEG 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380	15/74 (20%)
		C2_Dock-C	589..769	CDD:176078
		DHR2_DOCK_C	1614..2035	CDD:212568
DOCK7	NP_001354490.1	DOCK_C-D_N	52..161	CDD:463380	15/92 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..183		6/44 (14%)
		C2_Dock-C	560..737	CDD:176078
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	888..971
		DHR2_DOCK7	1644..2118	CDD:212576