Protein Alignment Zir and DOCK8

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_982272.2
• Gene: DOCK8 / 81704
• HGNCID: 19191
• Length: 2099
• Species: Homo sapiens
• Alignment Length: 2153
• Identity: 914/2153 - (42%)
• Similarity: 1328/2153 - (61%)
• Gaps: 212/2153 - (9%)

  Fly     2 SSAQRSFVQKVSKQSAADVRK------NVSGCH---LSKAMDPSL-CGSSISPTEPLDYEEFLSQ 56
            |:.:|:|..|:::.|:|::||      |:...|   :|.:..||| ......|.||:|:|..|..
Human     6 SAERRAFALKINRYSSAEIRKQFTLPPNLGQYHRQSISTSGFPSLQLPQFYDPVEPVDFEGLLMT 70

  Fly    57 HMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEY 121
            |:|.::....:.:.||...|:.|...|::.||:...:|.|.: :|..||::||..|.|.|.:|..
Human    71 HLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGV-ELDPHVRDCVQTYIREWLIVNR 134

  Fly   122 AQRHLSSSCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSES--CTPSSRQS------- 177
            ..:.....|..::...|               |||........::||:  |:..:.|:
Human   135 KNQGSPEICGFKKTGSR---------------KDFHKTLPKQTFESETLECSEPAAQAGPRHLNV 184

  Fly   178 ---IASLASVSSCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMAL 239
               ::....|::|           .||||....|..:.|||..|..|..::.||..|:.:||..|
Human   185 LCDVSGKGPVTAC-----------DFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAEL 238

  Fly   240 FSLYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENF 304
            |:|||..:.|:.:|.|.:.|.|.||:|:||.|..|.|:.|:|:||:|||:|:||.|||:||||||
Human   239 FALYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENF 303

  Fly   305 YFDMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPY--L 366
            :.|:|:|..|..|.:|......|:|:.||:|.::|||:|::||:::|||| ||:|.:..|||  :
Human   304 HCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVI 368

  Fly   367 KED---KDKYR-EKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNA 427
            ||.   |.|.: ||:|..|..:|:|||||||||||..|.|::.||....|.:   ..:.||....
Human   369 KESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLERE---VTDVDSVVGR 430

  Fly   428 CGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFR 492
              ||:|        :|::...|     |:.::.:.:|...|                  |..||:
Human   431 --SSVG--------ERRTLAQS-----RRLSERALSLEENG------------------VGSNFK 462

  Fly   493 PITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPEL 557
            ..|::|.||||||.|::.||||:|.|.:.||.||:.::.|.|||.::||||...|.....||||:
Human   463 TSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEM 527

  Fly   558 APINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGE 622
            .|:.|...:..||.|||||||...:|.||..|||||:|.|:.|||.::..|||||.:::|.|.||
Human   528 LPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGE 592

  Fly   623 TPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKK 687
            ...:|:..|:||||.|:|..|.:|||.||||.|.||:|:||.|||.:..:||||||.||:|||:|
Human   593 DASNAMPVIFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQK 657

  Fly   688 PQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSF-----IPPNVHLPGIKWLDN 747
            .   ..||||.:||:|||:|.:.:|:.|.:.|||.:|..|.|||.     :|  :..|.|||.:.
Human   658 Q---GASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVP--LQNPPIKWAEG 717

  Fly   748 HRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDT------RNIPSHIGENNIETELKKCLLDIEY 806
            |:.||:|.|:||:::||.|:.|::||.:|..|::      |.:...|.|..:|.|||..::.:..
Human   718 HKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNS 782

  Fly   807 ANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSL 871
            :..||||..|.||||||.:|.|....:.||..:.....||.:..:::.|....|...||:||..|
Human   783 SRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCL 847

  Fly   872 LSTYVHFQCKI------------------PHPFQSKQRLTCSRSTTEDLQ----------LSESY 908
            |::|||:..::                  |..:.:..|.:.:..:::.||          |:.::
Human   848 LASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTH 912

  Fly   909 TIYD----NVLAS---GRSLDRKEL----SIDVLHSMAA-RDVQVRLLHEELALHWVVASGKAAD 961
            :..|    |:::|   .|:..|...    |.|...|.|| |....:..||||||..||::|...:
Human   913 SAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQMVVSTGMVRE 977

  Fly   962 LAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGY---HSNEP 1023
            .....:||.|||:||||.:|:|..:..:..|:.||..:|.||::|:|::||:::...   ...|.
Human   978 TVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSEIAALLVKPQKEN 1042

  Fly  1024 KLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFV 1088
            :.|:.:|.||.||::|:||:|||||||.||:.|...|.:|.:::|.|::.:::||||:|||||::
Human  1043 EQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPTLISMRLEFLRILCSHEHYL 1107

  Fly  1089 ALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER---ALHADLSQEFLQQHFLVGLVLSDLA 1150
            .|||.|   ....|||.||.||.:|.|| :||.|.:.   |...||:.|:.|||||.||:.::||
Human  1108 NLNLFF---MNADTAPTSPCPSISSQNS-SSCSSFQDQKIASMFDLTSEYRQQHFLTGLLFTELA 1168

  Fly  1151 AVMEVPN---PQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHG 1212
            |.::...   .::..||:..|.:|::|||||.|..:.:.:.::||||:||:.|::|.:|||....
Human  1169 AALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLVGIILDALPQLCDFT 1233

  Fly  1213 L-EQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISG-------------SRPYSYLNEQVKNK 1263
            : :..|.:..|..|:.:|      |..||..||.||:|             |.||...|
Human  1234 VADTRRYRTSGSDEEQEG------AGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYN------ 1286

  Fly  1264 LPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLK 1328
             .|:::.||:|::||||::||.:::::.:|:.||...:::::|..:.:|:..|||.|::   :..
Human  1287 -MLNADTTRNLMICFLWIMKNADQSLIRKWIADLPSTQLNRILDLLFICVLCFEYKGKQ---SSD 1347

  Fly  1329 RTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRNS-----TEKFRWRKDQMPYRSQYA 1388
            :.:||..:|  |.|||.:|||.:.....||.:::.||...|.     .|..||:|:|..:| |..
Human  1348 KVSTQVLQK--SRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHWR-QAN 1409

  Fly  1389 DAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANL--YHNLLGTVLKVLLHSLSRNQS 1451
            :.:.|::.||:....|.|:||||..|::||..|.|:.|::.|  ..:|||.||:||::||:.:||
Human  1410 EKLDKTKAELDQEALISGNLATEAHLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQS 1474

  Fly  1452 VLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFE 1516
            ...|.:.||:.||||.||.:|||::|.:.|.|||..:|.||.|.:...||||.|:||||||.:|.
Human  1475 TTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFG 1539

  Fly  1517 IGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLH 1581
            ..:|||||||||||||:||||.:..|:|:.|||:|:|:|.|:|.|:.:|.|.||.||::||.||:
Human  1540 ATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLN 1604

  Fly  1582 MILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAA 1646
            .||.|||||:|:|||||||:|||.||||.||.:||||||||:|||:||.::..:||||||.||||
Human  1605 SILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAA 1669

  Fly  1647 SLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEE 1711
            :||:|||||||...:||||:||||.||.|.|.||.||:|.|||.|||:|.|.:|||:||..|||:
Human  1670 ALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQ 1734

  Fly  1712 ASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGF 1776
            |:..|...|:||.:|||||::|||.||:|:|:||:..|.|||.||:.|.....||:|||||||||
Human  1735 AAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGF 1799

  Fly  1777 YGGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQ 1841
            :|.||||||:|||:||||.:||||||..||:.||.:.||.:.|.:||||..||...|||:|||||
Human  1800 FGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQ 1864

  Fly  1842 ITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVK 1906
            ||:|||||:.|||:.|.||||:|||::||:|.||||..|:..|||:||.:|.|:|||.:.|||:|
Human  1865 ITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYIK 1929

  Fly  1907 TRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMAS 1971
            |||.||.:::.||.||||||||::||||:||.|.||||.|.|:|||||||.:|.||||||:|:|.
Human  1930 TRISVIQKEEFVLTPIEVAIEDMKKKTLQLAVAINQEPPDAKMLQMVLQGSVGATVNQGPLEVAQ 1994

  Fly  1972 VFLSNLSDGTTVPT-----KHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRF 2031
            |||:.      :|.     :|.|||||||:||..||.:|::||:.||.:||::||:||::|.::.
Human  1995 VFLAE------IPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQREYQQELKKNYNKL 2053

  Fly  2032 IERLTPFI 2039
            .|.|.|.|
Human  2054 KENLRPMI 2061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	21/91 (23%)
		C2_Dock-C	589..769	CDD:176078	91/184 (49%)
		DHR-2	1549..2037	CDD:284365	298/492 (61%)
DOCK8	NP_982272.2	DUF3398	73..164	CDD:288711	24/106 (23%)
		C2_Dock-C	559..739	CDD:176078	91/184 (49%)
		DHR2_DOCK8	1636..2057	CDD:212574	256/426 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149369
Domainoid	1	1.000	745	1.000	Domainoid score	I95
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1862	1.000	Inparanoid score	I60
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm41825
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	O	PTHR23317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5567
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800