Protein Alignment Zir and DOCK5

DIOPT Version :10

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_079216.4
• Gene: DOCK5 / 80005
• HGNCID: 23476
• Length: 1870
• Species: Homo sapiens
• Alignment Length: 2054
• Identity: 364/2054 - (17%)
• Similarity: 658/2054 - (32%)
• Gaps: 746/2054 - (36%)

  Fly   224 DQSNEARRQQDRQMALFSLYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFAS 288
            |..|.....:...:|||..:  ..|.:.||.::..|..:           || .|:|..:.||::
Human   168 DNGNILDPDETSTIALFKAH--EVASKRIEEKIQEEKSI-----------LQ-NLDLRGQSIFST 218

  Fly   289 ------------------------MAIYDAKERQKISENFYFDMNADSLKRMLSSHVQCADISTQ 329
                                    ||:||..:...||||:.....::.:.:.:.        ...
Human   219 IHTYGLYVNFKNFVCNIGEDAELFMALYDPDQSTFISENYLIRWGSNGMPKEIE--------KLN 275

  Fly   330 SHSAIF-EISYPSNDLF-----LVIRLEKVLQGDINNSVEPYLKEDKDKYREKVKSNAVDYCERL 388
            :..|:| ::|  |.||.     ||.::.:|  |.:.      |||.|               :..
Human   276 NLQAVFTDLS--SMDLIRPRVSLVCQIVRV--GHME------LKEGK---------------KHT 315

  Fly   389 GKYRMPFAWTGIYLTNVFNG--DNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFD 451
            ...|.||....:.:|::.:|  |:                               :.|.....|.
Human   316 CGLRRPFGVAVMDITDIIHGKVDD-------------------------------EEKQHFIPFQ 349

  Fly   452 QLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYK 516
            |:..:      |..|:..|       ..||...::|:....|:|..:......:....|.:.|:.
Human   350 QIAME------TYIRQRQL-------IMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWV 401

  Fly   517 ILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSA 581
            .|             |.:||.:       .:..||.         ....|....:...:.||:
Human   402 SL-------------KLLPGDL-------TQVQKNF---------SHLVDRSTAIARKMGFPE-- 435

  Fly   582 IYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGE-------TPK---------DAVNA 630
                        .:.|         |..|| .:.|.|:.||       |||         |....
Human   436 ------------IILP---------GDVRN-DIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGK 478

  Fly   631 IYGKSSCPKFSTEAF----TAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDL 691
            :..|:..|....|..    :.|.|..|.|.:|:.:|:::........|:.||..|    :..|:.
Human   479 LLEKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRH----RSSQET 539

  Fly   692 QPSVETPIGYTWLPLLE-DG-KLKFGEFNLPVMV--ESPPENYSFIPPNVHLPGIKWLDNHRAVF 752
            :...|...|..::.|:. || .|:.|..:|.|..  ....|:..|.   :.|||.| ::......
Human   540 RDKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFY---LTLPGTK-MEMEEKEL 600

  Fly   753 SINVEAVTAIHTLDSFLDRF---FLICEYLDTRNIPS------HIGENNIETELKKCLLDIEYAN 808
            ..:...||...:.||..|.|   .|||....|:|:..      .....||:..||| |::::...
Human   601 QASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKK-LMEVDGGE 664

  Fly   809 REPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGST----VFEVLCLVSSLLSILNDDQYDQYGRQ 869
               :|:.|...||.|..:::        .||...|    ||:.|..:   :|::.|.::..:  .
Human   665 ---IVKFLQDTLDALFNIMM--------EMSDSETYDFLVFDALVFI---ISLIGDIKFQHF--N 713

  Fly   870 SLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLH 932
            .:|.||:  ||...:.:                 ::||:....|   :|:.....:.||....|.
Human   714 PVLETYIYKHFSATLAY-----------------VKLSKVLNFY---VANADDSSKTELLFAALK 758

  Fly   933 SMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFP 997
            ::.                                 :||..|::|.:.:|.    ..|..|.  .
Human   759 ALK---------------------------------YLFRFIIQSRVLYLR----FYGQSKD--G 784

  Fly   998 HQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGF-----VFGLIKTYT 1057
            .:||:.:..|                           |..|::|  |||..     :.|....|.
Human   785 DEFNNSIRQL---------------------------FLAFNML--MDRPLEEAVKIKGAALKYL 820

  Fly  1058 KVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGS 1122
            ..:|:....:.|.:...:.|.:.:.|                        .|.......:.:|
Human   821 PSIINDVKLVFDPVELSVLFCKFIQS------------------------IPDNQLVRQKLNC-- 859

  Fly  1123 LERALHADLSQEFLQQHFLVGLVLSDLAAVM-EVPNPQLHGKAIRCIRNLMTSHDLDARYSETDA 1186
            :.:.:.:.|.::...:..|:.|:...|:..: :..|...|..:.:.:.|::...|
Human   860 MTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHEASSQLLSNILEVLD---------- 914

  Fly  1187 RARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAIS--- 1248
            |..|.|..:.:..|:...:.::::..:..:|          |.||       |...||..|:
Human   915 RKDVGATAVHIQLIMERLLRRINRTVIGMNR----------QSPH-------IGSFVACMIALLQ 962

  Fly  1249 --GSRPYSYLNEQVKNKLPLSSENTRHLLVCFL-------------------WVLKNLERN---- 1288
              ....||:.         :|:..||..::.||                   |::.|:.:|
Human   963 QMDDSHYSHY---------ISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFL 1018

  Fly  1289 --------VLYRWLMDLSPHRV---------------HQMLQGVNVCLKTFEYTGQKNVATLKRT 1330
                    ||.|:.||.:...:               |:.||     |:||....:..:.
Human  1019 RAINQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQ-----LETFSQAKRNKIV----- 1073

  Fly  1331 NTQSFRKTGSTDVKEKLEECIR------GTNSARY--DLINRRKDRNSTEKFRWRKDQMPYRSQY 1387
                 :|.|  |:::::...||      |.:..::  .::....:...|.:...||..:|.   :
Human  1074 -----KKYG--DMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPI---F 1128

  Fly  1388 ADAV-------GKS-----EHEL--ELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTV 1438
            .|.:       |..     |:||  :|...:||....|...|||:.| ::.|...:.|.:..|.|
Human  1129 FDMMQCEFNFSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKL-LLEHCRKHKYLSSSGEV 1192

  Fly  1439 LKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQA 1503
            ..:|:.||        |:||        ..:..::..||:
Human  1193 FALLVSSL--------LENL--------LDYRTIIMQDES------------------------- 1216

  Fly  1504 AASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTS 1568
                    ::|          :|..|:::
Human  1217 --------KEN----------RMSCTVNV------------------------------------ 1227

  Fly  1569 FPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERA 1633
                                 :..|:|                :...|:.:.:|..:...||:..
Human  1228 ---------------------LNFYKE----------------KKREDIYIRYLYKLRDLHRDCE 1255

  Fly  1634 NHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGN 1698
            |:||||            |..:|    |..:...|.:...|:.|.:.:.               .
Human  1256 NYTEAA------------YTLLL----HAELLQWSDKPCVPHLLQKDSY---------------Y 1289

  Fly  1699 HFTETGLK-ALLEEASNSFQVAGMYEAMNEVYKILIPICEAN-RDFQKLSKVHGKLQEAFNRISQ 1761
            .:|:..|| .|.:|..:.|....|:|...::.|.|....|:. .|::.|..:..|....:..|
Human  1290 VYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGNLLKKRASFYENI-- 1352

  Fly  1762 LQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDS 1825
            ::..|....||.||:||..|.. |..:.|||:.....:..:...||...:     |::.   |.:
Human  1353 IKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQF-----PNAE---KMT 1409

  Fly  1826 NTV----DINSLDPDKAYIQITYVEP-------YFETYEMRHRETYFERNFNIKRFIYATPFTKN 1879
            :|.    ||.|  ..|.|:|...|:|       |.:.........|:..| .:::|.|:.||.|.
Human  1410 STTPPGEDIKS--SPKQYMQCFTVKPVMSLPPSYKDKPVPEQILNYYRAN-EVQQFRYSRPFRKG 1471

  Fly  1880 GK-AHGELNEQCKRKTILTTANHFPYVKT--RIMVISRQQIVLEPIEVAIEDIQKKTLELAAATN 1941
            .| ...|.......:|..|||..||.:..  .:..||.::|  .|:|.|||.::.....::....
Human  1472 EKDPDNEFATMWIERTTYTTAYTFPGILKWFEVKQISTEEI--SPLENAIETMELTNERISNCVQ 1534

  Fly  1942 QEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSN-------------------------- 1976
            |...|..:    |.|:|.|.:...|..|.......|.:.
Human  1535 QHAWDRSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPL 1599

  Fly  1977 LSDGTTVPTKHQNKL---------RL--CFREFSKRCADALKKNRNLILSDQKDYQRELERNNDR 2030
            |::|..:   |..||         ||  ||||..::    ::|:..:|.......:|:..|....
Human  1600 LTEGIRI---HGEKLTEQLKPLHERLSSCFRELKEK----VEKHYGVITLPPNLTERKQSRTGSI 1657

  Fly  2031 FIERLTPFI--------TLTSVQNHGVVKANAYNNKSTP 2061
            .:    |:|        ::|||.: .||..::.::.:.|
Human  1658 VL----PYIMSSTLRRLSITSVTS-SVVSTSSNSSDNAP 1691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380
		C2_Dock-C	589..769	CDD:176078	45/203 (22%)
		DHR2_DOCK_C	1614..2035	CDD:212568	103/478 (22%)
DOCK5	NP_079216.4	SH3_DOCK1_5_A	12..67	CDD:212984
		DOCK_N	75..434	CDD:465040	63/385 (16%)
		C2	442..637	CDD:472691	50/203 (25%)
		DHR2_DOCK5	1238..1637	CDD:212581	100/451 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1679..1702		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1772..1870