Protein Alignment Zir and Dock8

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_083061.2
• Gene: Dock8 / 76088
• MGIID: 1921396
• Length: 2100
• Species: Mus musculus
• Alignment Length: 2147
• Identity: 921/2147 - (42%)
• Similarity: 1318/2147 - (61%)
• Gaps: 199/2147 - (9%)

  Fly     2 SSAQRSFVQKVSKQSAADVRK------NVSGCH---LSKAMDPSL-CGSSISPTEPLDYEEFLSQ 56
            |:.:|:|..|:::.|::::||      |:...|   :|.:..||| ......|.||:|:|..:..
Mouse     6 SAERRAFALKINRYSSSEIRKQFTLPPNLGQYHRHSISTSGFPSLQLPQLYEPVEPVDFEGLVMT 70

  Fly    57 HMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEY 121
            |:|.::.:..:.:.|....|:.|...|::.||:.|.:|.|.: :|..||::||..|.|.|.:|..
Mouse    71 HLNSLDAELAQELGDLTDDDLHVAFTPKECRTLQHSLPEEGV-ELDPHVRDCVQTYIREWLIVNR 134

  Fly   122 AQRHLSSSCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSESCTPSSRQSIASLASVS- 185
            ..:..|..|..::...|.....:..:|.||        .|.............|..:..|..||
Mouse   135 KNQGSSEFCSFKKTGSRRDFQKTLQKQTFE--------SETLECSEPDTQTGPRHPLNVLCDVSG 191

  Fly   186 -----SCTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPE 245
                 ||           .||||....|..:.|||..|..|..::..|..|:.:|...||:|||.
Mouse   192 KGPLTSC-----------DFDLRSLQPDERLENLLQLVSAEDFEKEKEEARKTNRPAELFALYPP 245

  Fly   246 SEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNA 310
            .:.|:.:|.|.:.|.|.||:|:||.|..|.|:.|:|:||:|||:|:||.|||:||||||:.|:|:
Mouse   246 VDEEDAVEIRPVPECPKEHLGNRILVKVLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNS 310

  Fly   311 DSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPYL---KEDKD 371
            |..|..|.:|....|.|:|:.||:|.::|||:|::||:::|||| ||:|.:..|||:   :.|..
Mouse   311 DQFKGFLRAHTPSIDPSSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIADCAEPYMIIKESDGG 375

  Fly   372 KYREKV---KSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLG 433
            |.:|||   |..|..:|:|||||||||||..|.|.:.||        ....||:|      :.:.
Mouse   376 KSKEKVEKLKLQAESFCQRLGKYRMPFAWAPISLASFFN--------ISTLERES------TDVE 426

  Fly   434 TAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITV 498
            .....||:..|.|.|   |.||.:.       |..|||..            .|..||:..|:..
Mouse   427 PGVGRNSVGEKRSLS---QSRRPSE-------RTLSLEEN------------GVGSNFKATTLAT 469

  Fly   499 PSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQ 563
            ..|||||.|::.||||:|.|.:.||.||:.::.|.||||::|||||..:.....||||:.|:.|.
Mouse   470 NIFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGSLRLEISPAPDVMNCCLTPEMLPVKPF 534

  Fly   564 SADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETPKDAV 628
            ..:..||.|||||||...:|.||..|||||:|.|:.|||:|:..|||||.:::|.|.||.|.:|:
Mouse   535 PENRTRPHKEILEFPIREVYVPHTVYRNLLYVYPQRLNFASKLASARNITIKIQFMCGEDPSNAM 599

  Fly   629 NAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQP 693
            ..|:||||.|:|..|.:||:.||||.|.||:|:||.|||.:..:||||||.||:|||:|.   ..
Mouse   600 PVIFGKSSGPEFLQEVYTAITYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQ---GA 661

  Fly   694 SVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSF-----IPPNVHLPGIKWLDNHRAVFS 753
            |.|:.:||:|||:|.:.:|:.|.:.|||.:|..|.|||.     :|  :..|.|||.:.|:.||:
Mouse   662 SGESLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSIHSAEKVP--LQNPPIKWAEGHKGVFN 724

  Fly   754 INVEAVTAIHTLDSFLDRFFLICEYLDT------RNIPSHIGENNIETELKKCLLDIEYANREPL 812
            |.|:||:::||.|:.|::||.:|..|::      |.:...|.|:.:|.|||..::.:..:..|||
Mouse   725 IEVQAVSSVHTQDNHLEKFFTLCHSLESQVSFPIRVLDQKITESTLEHELKLSIICLNSSRLEPL 789

  Fly   813 VRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVH 877
            |..|.||||||.:|.|....:.||..:.....||.:..:::.|....|.:.||:||..||::|||
Mouse   790 VLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLRKDQHGRNCLLASYVH 854

  Fly   878 FQCKIP--HPFQSKQ----------------RLTCSRSTTEDLQ----------LSESYTIYD-- 912
            :..::|  |...||.                |.:.:..:::.:|          |:.|:...|
Mouse   855 YVFRLPELHRDTSKSGGPTTVVPDPRYHTYGRTSAAAVSSKLMQARVMSSSNPDLTGSHCAADEE 919

  Fly   913 --NVLAS---GRSLDRKEL----SIDVLHSMAA-RDVQVRLLHEELALHWVVASGKAADLAMSNS 967
              |:::|   .|:..|...    :.|...|.|| |.|..:..||||||..||::|...:.....:
Mouse   920 VKNIMSSKIADRNCSRMSYYCSGNSDAPGSTAAPRPVSKKHFHEELALQMVVSTGVVRETVFKYA 984

  Fly   968 WFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGY---HSNEPKLAQSL 1029
            ||.|||:||||.:::|..:..:..|:.||..:|.||::|:|::||:::...   ...|.:.|:.:
Mouse   985 WFFFELLVKSMAQYVHNLDKRDSFRRTRFSDRFKDDITTIVNVVTSEIAALLVKPQKESEQAEKI 1049

  Fly  1030 NASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPF 1094
            |.||.||::|:||||||||||.|||.|...|.:|...:|.|::.:::||||:|||||::.|||.|
Mouse  1050 NISLAFFLYDLLSIMDRGFVFNLIKHYCSQLSAKLNILPTLISMRLEFLRILCSHEHYLNLNLLF 1114

  Fly  1095 GTSYTMVTAPCSPTPSTTSSNSQTSCGSLER---ALHADLSQEFLQQHFLVGLVLSDLAAVMEVP 1156
               ....|||.||.||.:|.|| :||.|.:.   |...||:.|:.|||||.||:.::||..::..
Mouse  1115 ---MNTDTAPASPCPSISSQNS-SSCSSFQDQKIASMFDLTPEYRQQHFLTGLLFTELAVALDAE 1175

  Fly  1157 N---PQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQH-GLEQDR 1217
            .   .::..||:..|.:|:.|||||.|..:.:.:.::||||:||:.|::|.:|||:.. .....|
Mouse  1176 GDGISRVQRKAVSAIHSLLCSHDLDPRCRKPEVKVKIAALYLPLVGIILDALPQLYDFTDARSGR 1240

  Fly  1218 LQQIGQLEDYQGPHQTITASTINPEVAFAISG-------------SRPYSYLNEQVKNKLPLSSE 1269
            .:..|..|:..      .|:.||..||.||:|             |.||...|       .|:::
Mouse  1241 SRASGSYEEQD------VANGINQNVALAIAGNHFNLKTSGAMLSSLPYKQYN-------MLNAD 1292

  Fly  1270 NTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQS 1334
            .||||::||||::||.:::::.:|:.||...:::::|..:.:|:..|||.|::   :..:.:.|.
Mouse  1293 TTRHLMICFLWIMKNADQSLIRKWIADLPSMQLNRILDLLFICVSCFEYKGKQ---SSDKVSNQV 1354

  Fly  1335 FRKTGSTDVKEKLEECIRGTNSARYDLINRR---KDR--NSTEKFRWRKDQMPYRSQYADAVGKS 1394
            .:|  |.|||.||||.:.....||.:::.||   .||  ...|..||||:|..:| |..:.:.|:
Mouse  1355 LQK--SRDVKAKLEEALLRGEGARGEMMRRRIPGTDRFPGINENLRWRKEQTQWR-QANEKLDKT 1416

  Fly  1395 EHELELSHFIEGSLATEVALVLLDTLEIIVHAAANL--YHNLLGTVLKVLLHSLSRNQSVLALQN 1457
            :.||:....|.|:||||..|::||..|.|:.|::.|  ..:|||.||:||::|||.:||...|.:
Mouse  1417 KAELDQEALISGNLATEANLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLSCDQSTTYLTH 1481

  Fly  1458 LFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFA 1522
            .||:.||||.||.:|||::|.:.|||||..:|.||.|.:...||||.|:||||||.:|...:|||
Mouse  1482 CFATLRALIAKFGDLLFEEEMEQCADLCQRVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFA 1546

  Fly  1523 RVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDT 1587
            ||||||||:|:||||.:..|:|:.|||:|:|:|.|:|.|:.:|.|.||.||::||.||:.||.||
Mouse  1547 RVKMQVTMALASLVGKAPDFNEEHLRRSLRTILAYSEEDTAMQTTPFPMQVEELLCNLNSILYDT 1611

  Fly  1588 VKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEY 1652
            |||:|:|||||||:|||.||||.||.:||||||||:|||:||.::...||||||.||||:||:||
Mouse  1612 VKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCFTEAAMCLVHAAALVAEY 1676

  Fly  1653 LSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQ 1717
            |||||...:||||:||||.||.|.|.|||||||.|||.|||:|.|.:|||:||..|||:|:..|.
Mouse  1677 LSMLEDHSYLPVGSVSFQNISSNVLEESAVSDDTLSPDEDGVCSGRYFTESGLVGLLEQAAELFS 1741

  Fly  1718 VAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFG 1782
            ..|:||.:|||||::|||.||:|||:||:..|.|||:||:.|.....||:|||||||||||.:||
Mouse  1742 TGGLYETVNEVYKLVIPILEAHRDFRKLTSTHDKLQKAFDNIINKDHKRMFGTYFRVGFYGSRFG 1806

  Fly  1783 DLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEP 1847
            |||:|||:||||.:||||||..||:.||.:.||.:.|.:||||..||...|||:|||||||:|||
Mouse  1807 DLDEQEFVYKEPAITKLPEISHRLEGFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEP 1871

  Fly  1848 YFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVI 1912
            ||:.|||:.|.||||:|||::||:|.||||..|:..|||:||.:|.|:|||.:.|||:||||.|.
Mouse  1872 YFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQHRRNTVLTTMHAFPYIKTRIRVS 1936

  Fly  1913 SRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNL 1977
            .:::.||.||||||||::||||:||.||:|||.|.|:|||||||.:|.||||||:|:|.|||:.
Mouse  1937 QKEEFVLTPIEVAIEDMKKKTLQLAVATHQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAE- 2000

  Fly  1978 SDGTTVPT-----KHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTP 2037
                 :|.     :|.|||||||:||..||.:|::|||.||.::|::||:||::|.::..:.|.|
Mouse  2001 -----IPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNRRLITAEQREYQQELKKNYNKLRDSLRP 2060

  Fly  2038 FI 2039
            .|
Mouse  2061 MI 2062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	23/91 (25%)
		C2_Dock-C	589..769	CDD:176078	90/184 (49%)
		DHR-2	1549..2037	CDD:284365	299/492 (61%)
Dock8	NP_083061.2	DUF3398	73..164	CDD:288711	23/91 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..453		9/38 (24%)
		C2_Dock-C	560..740	CDD:176078	90/184 (49%)
		DHR2_DOCK8	1637..2058	CDD:212574	257/426 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839428
Domainoid	1	1.000	742	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1863	1.000	Inparanoid score	I60
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm43876
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	O	PTHR23317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5567
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800