Protein Alignment Zir and Dock11

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_006541469.1
• Gene: Dock11 / 75974
• MGIID: 1923224
• Length: 2086
• Species: Mus musculus
• Alignment Length: 2269
• Identity: 669/2269 - (29%)
• Similarity: 1042/2269 - (45%)
• Gaps: 464/2269 - (20%)

  Fly     6 RSFVQKVSKQ-SAADVRKNVSGCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNIINRDPLKHI 69
            |.|.:::||. :||::|::|     |:|:..|:........||||||..::|....|..|||:.:
Mouse     5 RKFTKRLSKPGTAAELRQSV-----SEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDL 64

  Fly    70 LDFPQGDVTVKIIPRKIRTVDHVVPNE---NLSDLPHHVQECVNCYTRPWKVVEYAQRHLSSSCY 131
            |.||..|:::.:|.|:.|||...||.:   ....|  .|:||:..|:..|.||.|.....|...
Mouse    65 LMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSL--FVKECIKTYSTDWHVVNYKYEDFSGDF- 126

  Fly   132 IRERIDRGTISPSAYQQE-FEIDKDFSSFEEAF-------------------------------- 163
              ..:...::.|...... ||||:|....|::.
Mouse   127 --RMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFK 189

  Fly   164 -----------------AYKSESCTPSSRQSIASLASVSSCTDTL-TPRGSWASFDLRR------ 204
                             :||.|..:..|:..|    .:.:|.|.: .|:....:|:|:.
Mouse   190 RRYFYLTQLPDGSYILNSYKDEKNSKESKGCI----YLDACIDVVQCPKMRRHAFELKMLDKYSH 250

  Fly   205 ---------------------SVN-DPLIPNLLDNVP-------------------------PE- 221
                                 .:| |.|:....|.|.                         ||
Mouse   251 YLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPEL 315

  Fly   222 -----HIDQSNEARRQQDRQMALFSLYPE------SEAEENIERRLLAEIPVEH-MGHRIQVNCL 274
                 ..:|.|:..|...|| .|||...|      |..|.:::       |.|. ...|..|||.
Mouse   316 MKYGRETEQLNKLSRGDGRQ-NLFSFDSEVQRLDFSGIEPDVK-------PFEEKCNKRFMVNCH 372

  Fly   275 QLRLEL-------------EVEPIFASMAIYDAKERQKISENFYFDMNADSLKRM-------LSS 319
            .|...:             .|||.|.::|::|.|...|||.:|:.|:|..|::.|       ||:
Mouse   373 DLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSN 437

  Fly   320 HVQCADISTQS-------------HSAIFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLK-EDK 370
            .......|.:|             ...||.::.|..::|||:|:||||||:|.:..|||:| .|.
Mouse   438 DGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDP 502

  Fly   371 DKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTA 435
            .|..:||...|...|.|||:|||||||                     |.|..|
Mouse   503 IKTAQKVHRTAKQVCSRLGQYRMPFAW---------------------AARPIF----------- 535

  Fly   436 PSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPS 500
                                  .|:.|:|...|                     .|.|:
Mouse   536 ----------------------KDVQGSLDLDG---------------------RFSPL------ 551

  Fly   501 FFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINP--Q 563
             :||::.|:.:||:.|:|.|.|:|...  |.:.|||.:.:.:.....:..|.:|....|:.|  :
Mouse   552 -YKQDSSKLSNEDILKLLSEYKKPEKT--KLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEK 613

  Fly   564 SADNVRPVKEILEF-PQSAIY-NPHYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM-AGET 623
            :..|:  ..|:.|| |:...| .|...|:|.|:|.|.:|.:.|:.  ..||||||.|:.. :.|:
Mouse   614 NCQNI--TVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDES 676

  Fly   624 PKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ--- 685
            ...|:..||||.:...|:|.|:..|::||:.|.|||||||.||..:.|.||||||.|||||:
Mouse   677 DASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINT 741

  Fly   686 KKPQDLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVH--------LPGI 742
            |.....|.:||||:|:.|:|||:||::...|..|||....||   .::  ||:        ...|
Mouse   742 KGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPP---GYL--NVNDAESRRQSNADI 801

  Fly   743 KWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETELKKCLLDIEYA 807
            ||:|..:.:..|.....:.|:|.|..:.:||..|:.:.:       |...:..||.|.|..:...
Mouse   802 KWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQS-------GSKEVPGELIKYLKCLHAM 859

  Fly   808 NREPLVRHLPLVLDKLIELLV-VTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSL 871
            ..:.:::.||::|.:|..:|. :||:   ..:.:..|:.        ||.|::  :..:.|.:|.
Mouse   860 EIQVMIQFLPVILMQLFRVLTNMTHE---DDVPINCTMV--------LLHIVS--KCHEEGLESY 911

  Fly   872 LSTYVHFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAA 936
            |.:::.:..:...|           ||
Mouse   912 LRSFIKYSFRPEKP-----------ST-------------------------------------- 927

  Fly   937 RDVQVRLLHEELALHWVVASGKAADLAMSN-----SWFLFELIVKSMIEHLHCSNTLNGPRKHRF 996
              :|.:|:||.||...:....::||....|     |||.||:|.|||..:|...|.:..||..||
Mouse   928 --LQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRF 990

  Fly   997 PHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLI 1061
            |..::..|.:|:..:...|...::..|..:::.|.||..|:...|::|||||||.||..|.....
Mouse   991 PEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFS 1055

  Fly  1062 SKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERA 1126
            .|:..:  |..||.:||:.:|:|||::.||||..     ...|.........|.:.....|::..
Mouse  1056 PKDPKV--LAEYKFEFLQTICNHEHYIPLNLPMA-----FAKPKLQRVQDFFSFAVDRLTSVDSN 1113

  Fly  1127 LHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVA 1191
            |...||.|:.:.||||||:|.:.:..:: .|.::...||..|:||:..|..|.||...:.:|::|
Mouse  1114 LEYSLSDEYCKHHFLVGLLLRETSIALQ-DNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIA 1177

  Fly  1192 ALYIPLLSIVMDCIPQL-----------------------------HQHGLEQDRLQQIGQLEDY 1227
            .||:|.:.::::.|.:|                             ::..|..|:....|..::.
Mouse  1178 QLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNG 1242

  Fly  1228 QGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSEN------TRHLLVCFLWVLKNLE 1286
            .|..:..:..::.||.|.........|....|..::..:|..|      .|:||:|:|:::|.:.
Mouse  1243 HGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMIS 1307

  Fly  1287 RNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECI 1351
            .:.|..:...:||..:..:|..:.|||..|.|.|::|:|   |.:.....|....|.|.:....:
Mouse  1308 EDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIA---RVHDAWLSKHFGIDRKSQTMPAL 1369

  Fly  1352 RGTNSARYDLINRRKDRNSTEKFRWRKDQMPYRSQYADAVGKS---EH-----ELELSH--FIEG 1406
            |.                       |...|..|.|:..::..|   .|     |.::.|  .:||
Mouse  1370 RN-----------------------RSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEG 1411

  Fly  1407 SLATEVALVLLDTLEIIVHAAANLY-----HN-LLGTVLKVLLHSLSRNQSVLALQNLFASQRAL 1465
            :.||||:|.:|||:........|..     || |:..|..:.|..|...||.::|:::|||.|:.
Mouse  1412 NTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSF 1476

  Fly  1466 IFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI--GNNFARVKMQV 1528
            |.|||:..|....::||..|..:||.|.|.:...|::|:|.||||||.|||.  ...|.|..:|:
Mouse  1477 ISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQI 1541

  Fly  1529 TMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEY 1593
            .:::|.|:...::......:.:|..:..:|.||..::.|:||.:|:||...:..:|..|.:|||:
Mouse  1542 IIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEH 1606

  Fly  1594 QEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLES 1658
            ::|||||:||...:||.|.:.|:||.|||::|||.|.:..:.:||||||||.|:||:|:   |..
Mouse  1607 EKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEF---LHR 1668

  Fly  1659 QKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYE 1723
            :|..|.|..:|::|:||...|.|:.       ||...:..|::|..|..|||:..:....|..||
Mouse  1669 KKLFPSGCSAFKKITPNIDEEGAMK-------EDAGMMDVHYSEEVLLELLEQCVDGLWKAERYE 1726

  Fly  1724 AMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQ--GKRVFGTYFRVGFYGGK-FGDLD 1785
            .::|:.|::|||.|..|:|:||::|:..|..|:.:|.::.  .||:.||:|||.|||.. |.:.|
Mouse  1727 VISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEED 1791

  Fly  1786 QQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFE 1850
            .:|:|||||.||.|.||..||...|.|:||.::|.||:||:.|:...|||..|:||:|||:|||:
Mouse  1792 GKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFD 1856

  Fly  1851 TYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQ 1915
            ..|:..|:|.||||.||.||::..|:|.:||..|.:.|||||:|||||:|.|||||.||.:...|
Mouse  1857 DKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQ 1921

  Fly  1916 QIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDG 1980
            |:.|:||:||.::|:.||.||....:....|...||:.||||:...||.||:..|..|| |.|..
Mouse  1922 QVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFL-NESQA 1985

  Fly  1981 TTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFI 2039
            ...|.|..|:|:..||:|.:.|:.||:.|..||..||.:|...|:.|....::.|:..|
Mouse  1986 NKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDII 2044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	26/95 (27%)
		C2_Dock-C	589..769	CDD:176078	77/193 (40%)
		DHR-2	1549..2037	CDD:284365	210/490 (43%)
Dock11	XP_006541469.1	DUF3398	37..147	CDD:371776	35/114 (31%)
		PH_DOCK-D	161..283	CDD:270087	13/125 (10%)
		C2_Dock-D	639..828	CDD:176079	77/193 (40%)
		DHR2_DOCK11	1628..2040	CDD:212573	184/422 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660