DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zir and Dock5

DIOPT Version :9

Sequence 1:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster
Sequence 2:	NP_808448.2	Gene:	Dock5 / 68813	MGIID:	2652871	Length:	1868	Species:	Mus musculus

Alignment Length:	1869	Identity:	348/1869 - (18%)
Similarity:	599/1869 - (32%)	Gaps:	676/1869 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 SSNSLDRKSSTSSFDQLRRKAN------DMSGT------------LTRRGSLERKE--KHRSWSP 481
            |.|.|.|..|.....::.:..|      |:|.|            :.|.|.:|.||  ||.....
Mouse   255 SENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKEGKKHTCGLR 319

  Fly   482 DDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILP--ELKRPSSVMKKYKCIPGSIKLEISP 544
                      ||..:.|.........|:.||:....:|  ::...:.:.::        :|.:||
Mouse   320 ----------RPFGVAVMDISDIVHGKVDDEEKQHFIPFQQIAMETYIRQR--------QLIMSP 366

  Fly   545 CVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKEL--------- 600
            .:   .:.:..|..|:. ...:.|...||:....|.            |:||.|.|
Mouse   367 LI---TSHVIGENEPLT-SVLNKVIAAKEVNHKGQG------------LWVSLKLLPGDLTQVQK 415

  Fly   601 NFSSRAGSARNIAVRVQLMAGETPKDAVNAIY----------GKSSCPK--------FS------ 641
            |||.....:..||.::.......|.|..|.||          ||...||        |.
Mouse   416 NFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVFDEEGNLL 480

  Fly   642 -------------TEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQP 693
                         :|..:.|.|..|.|.:|:.:|:.:........|:.||..|    :..|:.:.
Mouse   481 EKAIHPGAGYEGVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFRH----RSSQESRD 541

  Fly   694 SVETPIGYTWLPLLE-DG-KLKFGEFNLPVMVESPPENYSFIPPNVHLPGIK-WLDNHRAVFSIN 755
            ..|...|..::.|:. || .|:.|..:| |:.:...:........:.|||.| .|:......|.|
Mouse   542 KSERAFGVAFVKLMNADGTTLQDGRHDL-VVYKGDNKKMEDAKYYLTLPGTKAELEEKELQASKN 605

  Fly   756 VEAVTAIHTLDSFLDRF---FLICEYLDTRNIPS------HIGENNIETELKKCLLDIEYANREP 811
            ....|.  :.||..|.|   .|||....|:|:..      .....||:..||| |::::...
Mouse   606 PSVFTP--SKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKK-LMEVDGGE--- 664

  Fly   812 LVRHLPLVLDKLIELLVVTHKVGGQAMSLGST----VFEVLCLVSSLLSILNDDQYDQYGRQSLL 872
            :|:.|...||.|..:::        .||...|    ||:.|..:   :|::.|.::..:  ..:|
Mouse   665 IVKFLQDTLDALFNIMM--------EMSDNETYDFLVFDALVFI---ISLIGDIKFQHF--NPVL 716

  Fly   873 STYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMA 935
            .||:  ||...:.|                 ::||:....|   :|:.....:.||....|.::.
Mouse   717 ETYIYKHFSATLAH-----------------VKLSKVLNFY---VANAEDPSKTELLFAALKALK 761

  Fly   936 ARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQ- 999
                                             :||..|::|.:.:|            ||..|
Mouse   762 ---------------------------------YLFRFIIQSRVLYL------------RFYGQS 781

  Fly  1000 -----FNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGF-----VFGLIK 1054
                 |||.:..|                           |..|:  ::|||..     :.|...
Mouse   782 EDGDEFNDSIRQL---------------------------FLAFN--TLMDRPLEEAVKIKGAAL 817

  Fly  1055 TYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTS 1119
            .|...:|:....:.|.|...:.|.:.:.|                        .|.......:.:
Mouse   818 KYLPSIINDVKLVFDPMELSVLFCKFIQS------------------------IPDNQLVRQKLN 858

  Fly  1120 CGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSET 1184
            |  :.:.:.:.|.|:...:..|:.| |:|          ||.|:             ||...::.
Mouse   859 C--MTKIVESSLFQQAECREVLLPL-LTD----------QLSGQ-------------LDDHSTKP 897

  Fly  1185 DARARVAALYIPLLSIVMDCIPQ-------LHQHGLEQDRLQQIGQL---EDYQGPHQTITASTI 1239
            |..|.     ..|||.:::.:.:       .|...:.:..|::|.:.   ...|.||       |
Mouse   898 DHEAS-----SQLLSNILEVLDRTDVGPTSAHVQLIMERLLRRINRTVIGMSRQSPH-------I 950

  Fly  1240 NPEVAFAISGSRP-----YSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSP 1299
            ...||..|:..|.     ||:.         :|:..||..::.||     :|..::::.|:
Mouse   951 GSFVACMIAVLRQMEDSHYSHY---------ISTFKTRQDIIDFL-----METFIMFKDLI---- 997

  Fly  1300 HRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINR 1364
                    |.||..|.:        ..:..|..:.|               :|..|.....|...
Mouse   998 --------GKNVYAKDW--------MVMNMTQNRVF---------------LRAINQFAEVLTKS 1031

  Fly  1365 RKDRNSTEKFRWRKDQMPYRSQYADAVGKSEHE-LELSHFIE----------GSLATEVALVLLD 1418
            ..|:.|.|...|       .:.:..||....|| |:|..|.|          |.:..|:...:.|
Mouse  1032 FMDQASFELQLW-------NNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDMRKEIGFRIRD 1089

  Fly  1419 TLEIIVHAAANLYHNL-----------LGTVLKVLL---------------------HSLSRNQS 1451
                       :::||           :|.:|:|.|                     .:||.|
Mouse  1090 -----------MWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGN-- 1141

  Fly  1452 VLALQNLFASQRALIFKFPNLLFDDETDICADLCL--ILLKHCGSLLPGIRSQAAASLYLLMRQN 1514
                .|....:..||.|....:.....|....:.|  :||:||                   |::
Mouse  1142 ----GNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHC-------------------RKH 1183

  Fly  1515 FEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRAL---KTVLVYAESDSDLQDTSFPEQVQDL 1576
            ..:.|:                |.:..|...||...|   :|::::.||..:.
Mouse  1184 KYLANS----------------GEAFAFLVSSLLENLLDYRTIIIHDESKENR------------ 1220

  Fly  1577 LFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMC 1641
                   :|.||.:..:.:|               :...|:.:.:|..:...||:..|:||||
Mouse  1221 -------MSCTVNVLNFYKD---------------KKREDIYIRYLYKLRDLHRDCENYTEAA-- 1261

  Fly  1642 YVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLK 1706
                      |..:|.::                           |....|..|:.:
Mouse  1262 ----------YTLLLHAE---------------------------LLQWSDKPCVPH-------- 1281

  Fly  1707 ALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAF-NRISQLQG------ 1764
             ||:.  :|:.|....|...::|:.:|...:..:.::|..|:..:|.|.: :::...:|
Mouse  1282 -LLQR--DSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGSLLK 1343

  Fly  1765 KRVF------------GTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGP 1816
            ||..            ..||.||:||..|.. |..:.|||:.....:..:...||...:     |
Mouse  1344 KRALFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQF-----P 1403

  Fly  1817 DSVHIIKDSNTV----DINSLDPDKAYIQITYVEP-------YFETYEMRHRETYFERNFNIKRF 1870
            ::.   |.::|.    ||.|  ..|.|:|...|:|       |.:.........|:..| .:::|
Mouse  1404 NAE---KMTSTTPPGEDIKS--SPKQYLQCFTVKPVMSLPPSYKDKPVPEQILNYYRAN-EVQQF 1462

  Fly  1871 IYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLE---PIEVAIEDIQK 1931
            .|:.||.|..| ...|.......:|...||..||.:   :.....::|.:|   |:|.|||.::.
Mouse  1463 SYSRPFRKGEKDPENEFATMWIERTTYRTAYTFPGI---LKWFEAKEISVEEISPLENAIETMEL 1524

  Fly  1932 KTLELAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLSN---------------- 1976
            ....::....|...|..:    |.|:|.|.:...|..|.......|.:.
Mouse  1525 TNERVSNCVQQHAWDHSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELL 1589

  Fly  1977 ----------LSDGTTVPTKHQNKL---------RL--CFREFSKRCADALKKNRNLILSDQKDY 2020
                      |::|..:   |..||         ||  ||||..::    ::|...:|.....
Mouse  1590 KRLIALQIPLLTEGIRI---HGEKLTEQLKPLHARLSSCFRELKEK----VEKLYGVITLPPS-- 1645

  Fly  2021 QRELERNNDRFIERLTPFI--------TLTSVQNHGV-VKANAYNNKST 2060
              ..||...|....:.|:|        ::|||.:..: ..:|:.:|.|:
Mouse  1646 --MTERKPSRAGSMVLPYILSSTLRRLSVTSVASSVISTSSNSSDNASS 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	51/228 (22%)
		DHR-2	1549..2037	CDD:284365	107/566 (19%)
Dock5	NP_808448.2	SH3_DOCK1_5_A	12..67	CDD:212984
		DOCK_N	75..434	CDD:292790	42/212 (20%)
		C2	442..637	CDD:301316	46/201 (23%)
		DHR2_DOCK5	1238..1637	CDD:212581	95/469 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1730		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1742..1868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740