DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zir and DOCK6

DIOPT Version :9

Sequence 1:NP_608489.2 Gene:Zir / 33165 FlyBaseID:FBgn0031216 Length:2064 Species:Drosophila melanogaster
Sequence 2:XP_005260057.1 Gene:DOCK6 / 57572 HGNCID:19189 Length:2113 Species:Homo sapiens


Alignment Length:2159 Identity:993/2159 - (45%)
Similarity:1342/2159 - (62%) Gaps:196/2159 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SSAQRSFVQKVSKQSAADVRKNVS-----GCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNII 61
            :|.:|:|..|:::..||:|||.||     ..|.|:....||........||||:|:.|.......
Human     3 ASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVLLSRPPDA 67

  Fly    62 NRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEYAQRHL 126
            ...||:.:::||..|:.:.:.||:.||.:..:|.:...|.  .|:..|..|...|.:|....::|
Human    68 EPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDA--QVRAAVEMYIEDWVIVHRRYQYL 130

  Fly   127 SSSCYIRERIDRGTISPSAYQQEFEIDKDF--SSFEEAFAYKSESCTPSSRQSIASLASVSSCTD 189
            |::           .||.....:.|..|..  ..||:..:....|....|..|.....|...   
Human   131 SAA-----------YSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPED--- 181

  Fly   190 TLTPRGSWAS--FDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPESEAEENI 252
              |||.|.||  ||||....|.|:|:||:...||.:|:.||..|:|.|..||.:|||..:.:|.:
Human   182 --TPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDEDEAV 244

  Fly   253 ERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRML 317
            ||....|.|.||.|.||.|.||.|:.|:|:||||..:|:||.:|::|||||||||:|:||:|.:|
Human   245 ERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDLNSDSMKGLL 309

  Fly   318 SSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPY--LKE-----DKDKYR 374
            .:|.....|||.:.||||.::|||.|:||||:||||| ||||:...|||  |||     :|:|. 
Human   310 RAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMVLKEVDTAKNKEKL- 373

  Fly   375 EKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSN 439
            ||::..|..:|.|||:||||||||.::|.|:.:       .||..:|||             .|.
Human   374 EKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVS-------SAGQLDRDS-------------DSE 418

  Fly   440 SLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQ 504
            ...|.:.|   |:.||...|                 |:.|.|| |.....|||.|:||.:||||
Human   419 GERRPAWT---DRRRRGPQD-----------------RASSGDD-ACSFSGFRPATLTVTNFFKQ 462

  Fly   505 EADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNVR 569
            ||:::.||||:|.|.:::||||::::.:.:...:|::|||..|.....|:|||..|.|......|
Human   463 EAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGR 527

  Fly   570 PVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETPKDAVNAIYGK 634
            |.|||||||...:|.||.||||||:|.|..||||||.||.||:|||||.|.||.|..|:..|:||
Human   528 PTKEILEFPAREVYAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGK 592

  Fly   635 SSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPI 699
            |||.:|:.||||.|.||||.|.||:|.|:.|||.:.::||||||.||||||.:|   ..::|||:
Human   593 SSCSEFTREAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRP---GTALETPV 654

  Fly   700 GYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVEAVTAIHT 764
            |:||:|||:.|:|:.|.|.|||.|:.||.:||.:.|:|.|||::|:|.|:.|||:.:.||:::|.
Human   655 GFTWIPLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHP 719

  Fly   765 LDSFLDRFFLICEYLDTRNIP-----SHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLI 824
            .|.:||:||.:...|:....|     :.:.|.|:|.||:..|..:..|:.||||.....|||||:
Human   720 QDPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVLDKLV 784

  Fly   825 ELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIP------ 883
            .|::....:.||.::||...||.:..|.||:....:...|..|....|:.|||:..::|      
Human   785 RLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAFRLPGTEPSL 849

  Fly   884 ---HPFQSKQRLTCSRST--TEDLQLSESYTI-----------------YDNVLASGRSLDRK-- 924
               .|..:.|..|.:|.:  ...|.|:.|.:|                 ...:||| :.:||.  
Human   850 PDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVSRILAS-KGIDRSHS 913

  Fly   925 --------------------------ELSIDVLHSMAA---------------RDVQVRLLHEEL 948
                                      ..:||...|.|:               |....:||||||
Human   914 WVNSAYAPGGSKAVLRRAPPYCGADPRQAIDCNSSRASSYLEGSSSAPPATQLRPTVQKLLHEEL 978

  Fly   949 ALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTT 1013
            ||.|||:|....:..:.::||.|:|:||||..||.....|:.|||.|||.:|.||::.||..|..
Human   979 ALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRFPGRFLDDITALVGSVGL 1043

  Fly  1014 KVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPD---LMNYKI 1075
            :|:.....:.:||:.|||||.||:.|:||::||||||.|::.:.|.:.::..|.|:   |:..::
Human  1044 EVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAHYKQVATRLQSSPNPAALLTLRM 1108

  Fly  1076 DFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER-----ALHADLSQEF 1135
            :|.||:|||||:|.||||    ...::.|.||:||.:|:.||:|..|.:.     ....:||..|
Human  1109 EFTRILCSHEHYVTLNLP----CCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVTSMFELSGPF 1169

  Fly  1136 LQQHFLVGLVLSDLAAVMEVPNPQ----LHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP 1196
            .|||||.||:|::||..:| |..:    ||.|||..:.:|:..||.|.||:|...:||||.||:|
Human  1170 RQQHFLAGLLLTELALALE-PEAEGAFLLHKKAISAVHSLLCGHDTDPRYAEATVKARVAELYLP 1233

  Fly  1197 LLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVK 1261
            ||||..|.:|:||.......:..::..:.|.....:...|.||||.||.||:|..........:.
Human  1234 LLSIARDTLPRLHDFAEGPGQRSRLASMLDSDTEGEGDIAGTINPSVAMAIAGGPLAPGSRASIS 1298

  Fly  1262 NKLP--------LSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEY 1318
            ...|        ||:|::|.||.|.||||||.|..:|.||..||:..::.::|..:.:||..|||
Human  1299 QGPPTASRAGCALSAESSRTLLACVLWVLKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEY 1363

  Fly  1319 TGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRN---STEKFRWRKDQ 1380
            .|:|   ..:|.|:.:|:|  |.|:|.:|||.|.||..||.:::.|.::|:   :.|..|||| .
Human  1364 KGKK---AFERINSLTFKK--SLDMKARLEEAILGTIGARQEMVRRSRERSPFGNPENVRWRK-S 1422

  Fly  1381 MPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA--ANLYHNLLGTVLKVLL 1443
            :.:..|.:|.|.|::.|:|....:||:||||.:||:||||||||...  :....::||.||||:|
Human  1423 VTHWKQTSDRVDKTKDEMEHEALVEGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVL 1487

  Fly  1444 HSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLY 1508
            :||...||.|.||:..|:||||:.|||.|||:::|::||||||.||:||||.:..||:.|:||||
Human  1488 YSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLY 1552

  Fly  1509 LLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQV 1573
            ||||||||||:|||||||||||||||||||:..|||:.|||:|||:|.|||.|..|:|::|.|||
Human  1553 LLMRQNFEIGHNFARVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQV 1617

  Fly  1574 QDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEA 1638
            |||:|||||||:|||||||:|||||||:|||.|||:|||.:||||||||:|||.||.|..||.||
Human  1618 QDLMFNLHMILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEA 1682

  Fly  1639 AMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTET 1703
            |.|.||||:||:|||::||..:|||||.||||.||.|.|.|||:|||:|||.|:|.|.|.||||.
Human  1683 AQCMVHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTEL 1747

  Fly  1704 GLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRI-SQLQG-KR 1766
            ||..|||:|:..|.:.|:|||:|||||.||||.||:||::||:.|||||||||.:| .|..| :|
Human  1748 GLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQSSGWER 1812

  Fly  1767 VFGTYFRVGFYGGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDIN 1831
            ||||||||||||..|||||:|||:||||::|||.||..||:.|||||||.|.|.||||||.||.:
Human  1813 VFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVEIIKDSNPVDKS 1877

  Fly  1832 SLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTIL 1896
            .||..|||||||||||||:|||::.|.|||:||:.::.|::.||||.:|:|||||.||.||||:|
Human  1878 KLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDGRAHGELPEQHKRKTLL 1942

  Fly  1897 TTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTT 1961
            :|.:.|||:||||.|..|::.||.|:||||||:||||.|||.||.|:|.|.|:|||||||.:|.|
Human  1943 STDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFATEQDPPDAKMLQMVLQGSVGPT 2007

  Fly  1962 VNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELER 2026
            |||||:|:|.|||:.:.:...: .:|.|||||||::|.|:|.|||:||:.||..|||:|.|||||
Human  2008 VNQGPLEVAQVFLAEIPEDPKL-FRHHNKLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELER 2071

  Fly  2027 NNDRFIERLTPFIT 2040
            |..|..|.|.|.:|
Human  2072 NYCRLREALQPLLT 2085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZirNP_608489.2 DUF3398 59..151 CDD:288711 20/91 (22%)
C2_Dock-C 589..769 CDD:176078 100/179 (56%)
DHR-2 1549..2037 CDD:284365 320/489 (65%)
DOCK6XP_005260057.1 DUF3398 65..155 CDD:288711 22/102 (22%)
C2_Dock-C 547..724 CDD:176078 100/179 (56%)
DHR2_DOCK6 1658..2080 CDD:212575 271/422 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 745 1.000 Domainoid score I95
eggNOG 1 0.900 - - E1_KOG1997
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1862 1.000 Inparanoid score I60
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55633
OrthoDB 1 1.010 - - D14993at33208
OrthoFinder 1 1.000 - - FOG0000340
OrthoInspector 1 1.000 - - otm41825
orthoMCL 1 0.900 - - OOG6_100358
Panther 1 1.100 - - LDO PTHR23317
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5567
SonicParanoid 1 1.000 - - X255
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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