DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zir and dock5

DIOPT Version :9

Sequence 1:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster
Sequence 2:	NP_001103482.1	Gene:	dock5 / 571688	ZFINID:	ZDB-GENE-080108-4	Length:	1867	Species:	Danio rerio

Alignment Length:	2010	Identity:	380/2010 - (18%)
Similarity:	655/2010 - (32%)	Gaps:	624/2010 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 RQMALFSLYPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQK 299
            ||.:...::|.|...       |.|..||..|.:..|...:|.|..|:....        :|..:
Zfish    51 RQKSQKGIFPASYIH-------LKEAKVEGTGKQETVVPTELPLVQELGTTL--------REWTQ 100

  Fly   300 ISENFYFDMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLF--------------LVIRL 350
            |....|.: |..:|.|.:.   |.|....:..|.|...:.|::||.              .::.|
Zfish   101 IWHKLYVN-NKSTLFRNVQ---QMAYSLIEYRSQIVSGTLPNDDLVELKKKVTAKIDYGNRILGL 161

  Fly   351 EKVLQGDINNSVEPYLKEDKDKYR-EKVKSNAVDYCERLGKYRMPF---------AWTGIYLTN- 404
            :.|::.:..|:::|........:| .:..|:::|  ||:.:.:|..         .::|::..:
Zfish   162 DLVVRDEAGNTLDPESSSTVSLFRAHESASHSID--ERIQEEKMRLQNLEKRRQSLFSGVHTYSL 224

  Fly   405 VFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKAN------DMSGT 463
            :.|..||.......||  .|.:..........|.|.|.|..||....::.:..|      |::.:
Zfish   225 LMNLRNFVCNIGEDAE--LFMSLYDPDKSEFISENFLVRWDSTGMPKEIEKLNNLPALFTDLNSS 287

  Fly   464 ------------LTRRGSLERKE--KHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDL 514
                        :.|.|.:|.||  ||.....          ||..:.|.........|..|:|.
Zfish   288 DLLRQRLFLVCQIIRVGCMELKEGKKHTGGLR----------RPFGVAVMDITDIAHGKTDDDDK 342

  Fly   515 YKILP--------ELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNAL--------------TPEL 557
            ...:|        .:::...:|.  ..||..:..|..|.|......:              |.:|
Zfish   343 QYFIPFQQIAMETYIRQRQLIMS--PLIPSRVIGENEPLVAVFNKVIATREVNHKGQGLFVTLKL 405

  Fly   558 APIN--------PQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFS-SRAGSARNIA 613
            .|.:        |...|....:...:.||:  |..|.| .||.::|:..:..|. .:..:.:|:.
Zfish   406 LPGDVFQVQKDYPHFVDRTTAIVRKMGFPE--IILPGY-VRNDIYVTLLQGEFDRGKKKTPKNVE 467

  Fly   614 VRVQLMAGE-TPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLF 677
            |.|.::..| .|.:  .||:..:..... ||..:.:.|..|.|.:.:.:|:|:|.......||..
Zfish   468 VIVSVLDEEGNPME--KAIFPGAGYEGI-TEYKSVIYYQVKQPCWNETVKVAIPIEDVCRCHLRL 529

  Fly   678 TIYHVSCQKKPQDLQPSVETPIGYTWLPL-------LEDGKLKFGEFNLPVMVESPPENYSFIPP 735
            |..|    :..||.:...|.|.|..::.|       |.|||.:...:.:........:.|
Zfish   530 TFRH----RSSQDSRDKSEKPFGMAFVRLMKSDGTTLPDGKHELIVYKVDGKKADDAKTY----- 585

  Fly   736 NVHLPGIKWLDNHRAVFSINVEAVTAIH-------TLDSFLDRFFLICEYLDTRNIPSHIG---- 789
             :.|||     .:..|.....:...:.|       |.||| ....|.|....|:|: ..:|
Zfish   586 -LSLPG-----TYTEVEEKERQTGKSFHHGGAVPVTKDSF-QIATLTCSTKLTQNV-DLLGLLNW 642

  Fly   790 ENNIE--TELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVS 852
            .:|.|  .|:.:.|:::|...   :::.|...||.|..:::.|    .:..:..:.||..|..:
Zfish   643 RSNTERLEEILQKLMEVEGGE---IIKFLQDTLDALFNIMMET----SEEETYDTLVFNALVFI- 699

  Fly   853 SLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVL 915
              :|::.|.::..:  ..:|.||:  ||...:.:     |:||
Zfish   700 --ISLIGDIKFQHF--NPVLETYINKHFSATLAY-----QKLT---------------------- 733

  Fly   916 ASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIE 980
                    |.|:..|.|   |.|    ..|.|.    :.|:.||..       :||..||:|.:.
Zfish   734 --------KVLNYFVGH---AED----STHTER----LYAALKAFK-------YLFRFIVQSRVL 772

  Fly   981 HLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMD 1045
            :|....      |.....||.|.:.||                           |....||  ||
Zfish   773 YLRFYG------KSEDGGQFQDSIRTL---------------------------FLSISIL--MD 802

  Fly  1046 RGF-----VFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPC 1105
            |..     :.|.|..|...:|:....:.|.:...:...:.:.|        :|   .:.||
Zfish   803 RPLDEGVKIKGAILKYLPTIINDLQKVFDAVELSVQLSKFIES--------IP---DFQMV---- 852

  Fly  1106 SPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEVPNPQLHGKAIRCIRN 1170
                       :...|.|.:.:.::|.::...:..|:.|:...|
Zfish   853 -----------RQKLGCLVKIVESNLFKQPDCRDVLLPLITDQL--------------------- 885

  Fly  1171 LMTSHDLDARYSETDARARVAALYIPLLSIVMDCI------PQLHQHGLEQDRLQQIGQLEDYQG 1229
               |..||...::.|..|     .:.|||.|:|.:      |......|..|||.
Zfish   886 ---SGQLDDNSNKPDLEA-----CVQLLSTVLDMLDCKNVGPTSGHVKLIVDRLL---------- 932

  Fly  1230 PHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLE-------- 1286
              :.:..:.||                       |.|.|....|.|.|...:||.:|
Zfish   933 --RRVNRTVIN-----------------------LSLDSPYIGHYLACMTAILKQMEDAHYAQYI 972

  Fly  1287 -----RNVLYRWLMD------------LSPHRVHQMLQGVNVCLKTF-EYTGQKN---------- 1323
                 |..:..:||:            ..|..:...|..:.|.|:.. :|:...|
Zfish   973 NTFKTRQDVIDFLMETFIMFKNLMGNVFPPDWMIMNLLQMKVFLRAIDQYSEVLNKGFLDYASFH 1037

  Fly  1324 -----------VA--TLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFR 1375
                       ||  |.|....:||    |.:.::|              ::|:..|...:..|:
Zfish  1038 LQLWNNYFHLIVAFLTHKSLQLESF----SPEKRDK--------------ILNKYGDMRKSIGFK 1084

  Fly  1376 WRK---DQMPYRSQYADAVGKSEHELELSHFIEGSLATEVAL------VLLDTLEIIVHAAANLY 1431
            .|.   :..|.:.::..|:        :...:|.:|..|..|      :..|.::...|...|
Zfish  1085 LRDMWYNLGPQKMKFIPAM--------VGPILEATLVPEPELRKATIPIFFDMMQCEHHFTTN-- 1139

  Fly  1432 HNLLGTVLKVLLHSLSR--NQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGS 1494
                        |:..:  |:.:..|.......|.          |::..|..:  ..||:||
Zfish  1140 ------------HTFQKFENELITKLDQEVEGGRG----------DEQYKILLE--KTLLEHC-- 1178

  Fly  1495 LLPGIR-----SQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTV 1554
                 |     ||...:|.||                     ||||               |:.:
Zfish  1179 -----RRHRYLSQPGEALALL---------------------LSSL---------------LENL 1202

  Fly  1555 LVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGY--QNNPDL 1617
            |.|.....|                               |.||:.:.....:...|  :...|:
Zfish  1203 LAYRTFTHD-------------------------------ESPELRMSCTVNLLNFYKEKKREDI 1236

  Fly  1618 RLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAV 1682
            .:.:|..:...|....|:||||    :...|.:|.|...|            :..||:
Zfish  1237 YIRYLYKLRDLHLVCENYTEAA----YTLLLHAELLEWSE------------KPCSPH------- 1278

  Fly  1683 SDDVLSPGEDGICLGNHFTETGLK-ALLEEASNSFQVAGMYEAMNEVYKILIPICEANR-DFQKL 1745
                |.||:    ....:|:..|| .|.:|...:.....|:|...|:.|.|:.:.|... ||.:|
Zfish  1279 ----LIPGD----AAQVWTQQELKERLFQEIMCNLDKGKMWEKAIEMAKQLVKLHENQMFDFIEL 1335

  Fly  1746 SKVHGKLQEAFNRISQLQGKRVFGTYFRVGFYGGKFGD-LDQQEFIYKEPTLTKLPEIFSRLQNF 1809
            .::..:..:.:..|  :...|....||.||:||..|.. |..:.|||:......|.:...:|.:.
Zfish  1336 GQLLKQQAQYYENI--MHAMRPQPEYFAVGYYGQGFPSFLRNKMFIYRGKEYEWLEDFSLKLLSQ 1398

  Fly  1810 YTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEP------YFETYEMRHRETYFERNFNIK 1868
            :     |::|.:...|...| |.......:||...|:|      :|:...:..:...:.|...:.
Zfish  1399 F-----PNAVRMTSTSPPAD-NICSSTGQHIQCFTVKPVLNLPSHFKDKGLPEQILNYYRTNEVD 1457

  Fly  1869 RFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKK 1932
            :|.|:.||.|..| ...|.......:|...||..||.:.....|.|.....:.|::.|||.::..
Zfish  1458 KFQYSRPFRKGEKDPDNEFATMWIERTTFITAYRFPGILKWFEVKSMSVEEISPLDNAIETMELA 1522

  Fly  1933 TLELAAATNQEPADPKI----LQMVLQGCIGTTVNQGPMEMASVFLS------NLSDGTTVPT-K 1986
            ..:|:....|:..|...    |.|:|.|.:...|..|.......|.:      |......:.. |
Zfish  1523 NEKLSNLVQQQACDRSCPVHPLSMMLNGIVDPAVMGGFSNYEKAFFTEAYMKKNPDHLERIEVLK 1587

  Fly  1987 HQNKLRL-----CFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFITL 2041
            |...|::     ..|...::..:.||...|.|::..:|.:.:        :|:|...|||
Zfish  1588 HLIALQIPLLDEGIRIHGEKSTEQLKPLHNRIVTCFQDLRAK--------VEKLYGVITL 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	42/195 (22%)
		DHR-2	1549..2037	CDD:284365	105/515 (20%)
dock5	NP_001103482.1	SH3_DOCK1_5_A	12..67	CDD:212984	4/22 (18%)
		DOCK_N	71..434	CDD:292790	70/390 (18%)
		C2	442..636	CDD:301316	47/213 (22%)
		DHR2_DOCK	1235..1634	CDD:297424	96/445 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830