Protein Alignment Zir and dock7

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_021332839.1
• Gene: dock7 / 568817
• ZFINID: ZDB-GENE-050302-15
• Length: 2144
• Species: Danio rerio
• Alignment Length: 2213
• Identity: 1057/2213 - (47%)
• Similarity: 1434/2213 - (64%)
• Gaps: 244/2213 - (11%)

  Fly     5 QRSFVQKVSKQSAADVRKNVSGCH-----LSKAMDPSLCGSSIS-------PTEPLDYEEFLSQH 57
            :|:|.||:|:..||:|||.::|.:     |.|.:  |:.|::.|       ..||:|:||:|..|
Zfish     4 RRAFAQKISRTVAAEVRKQIAGQYGGSPQLLKNL--SVGGNATSNAIPLTEAVEPVDFEEYLITH 66

  Fly    58 MNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEYA 122
            ..||...||:.:::||..|:.|...||:.||:...||.|..:|  .||::|...||..|.:|. .
Zfish    67 PPIIESGPLRDLIEFPPDDIEVLYTPRECRTLSQAVPEEGEND--PHVRDCTRSYTEDWAIVN-R 128

  Fly   123 QRHLSSSCYIRERID------RGTISPSAYQQEFEIDK--DFSSFEEAFAYKSESCTPSSRQSIA 179
            :.|...:.:....:|      ||.  |   :|.||.|:  |.||::       :......|:|:
Zfish   129 KYHKLGTAFNPNTLDKQKERQRGL--P---KQVFESDELPDQSSYQ-------DDQDDLKRRSM- 180

  Fly   180 SLASVSSCTDTLTPRGSWAS--FDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSL 242
                  |..|  |||||||.  |||:.|..|.|:|:|||.||.|.||:.||..|:.:|...||:|
Zfish   181 ------SIDD--TPRGSWACSIFDLKNSQPDALLPHLLDRVPNEEIDRHNEDLRKSNRHRELFAL 237

  Fly   243 YPESEAEENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFD 307
            :|..:.||.|||..:.::|.||.|.|:.|.||.|:.|:|:|||||::|:||.||::|||||||||
Zfish   238 HPALDEEEPIERHCVPDVPKEHFGQRLLVKCLSLKFEIEIEPIFATLALYDVKEKKKISENFYFD 302

  Fly   308 MNADSLKRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPYL--KE- 368
            :|::..|.||..|:..|.|||.:.||:|.|:|||.|:||||:||||| ||||....|||:  ||
Zfish   303 LNSEQTKGMLRPHIPSAAISTLARSAVFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMVFKES 367

  Fly   369 ----DKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACG 429
                :|:|. ||::|.|..:|:|||:||||||||.|:|.|:.|       .||:.|||
Zfish   368 DAAKNKEKL-EKLRSQAEQFCQRLGRYRMPFAWTAIHLMNIVN-------SAGSLERD------- 417

  Fly   430 SSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPI 494
                |.......:||.|.|.    ||     :.::..|.|||     |:.|.|:..::. :|||.
Zfish   418 ----TEVDMGLSERKGSWSE----RR-----NSSIVGRRSLE-----RTTSGDESCSLT-SFRPA 463

  Fly   495 TITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAP 559
            |:||.:|||||.|::.||||||.|.:::|||||:::.:.|...:|::|||..|.....|||:|..
Zfish   464 TLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPDLLQ 528

  Fly   560 INPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETP 624
            :.|.....|||.|||||||...:|.|:.:|||||:|:|:.|||::|.||||||.|:||.|.||.|
Zfish   529 VKPYPDSRVRPTKEILEFPARDVYVPNTTYRNLLYVNPQSLNFANRQGSARNITVKVQFMNGEDP 593

  Fly   625 KDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQ 689
            .:|:..|.|||||.:||.||:|:|.|||:.|.||||:||.||||:..|||:|||.||||||:|.
Zfish   594 SNAMPVISGKSSCAEFSKEAYTSVVYHNRSPDFYDEVKIKLPASLTDHHHILFTFYHVSCQQKQ- 657

  Fly   690 DLQPSVETPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSI 754
              ...:|||:||||:|:|::|:|:.|.|.|||.:|.||::||.:.|:|.|||:||:||||.||::
Zfish   658 --NTPLETPVGYTWIPMLQNGRLRTGHFCLPVSLEKPPQSYSVLSPDVPLPGMKWVDNHRGVFNV 720

  Fly   755 NVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIG-----ENNIETELKKCLLDIEYANREPLVR 814
            .|.|.:.|||.|.:||:||.:...||....|..||     |||:|||||..:..:..:..||:||
Zfish   721 EVVAASTIHTQDQYLDKFFALVHALDEHMFPVRIGDMRIMENNLETELKSSIAALNSSQLEPVVR 785

  Fly   815 HLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQ 879
            .|.|:||||:.|:|....:.||.::||...|||:..:.:.|....|...|.:||.||||:|:|:.
Zfish   786 FLHLLLDKLVLLMVRPPVIAGQIVNLGQASFEVMASIVNRLHKYLDTSQDMHGRNSLLSSYIHYV 850

  Fly   880 CKIPH-----PFQ-------SKQRLTCSRSTTE--DLQLSESYTIY--------------DNV-- 914
            .::|:     |..       |....|.:||...  .|.|:.|.::.              |.|
Zfish   851 FRLPNMDPNSPSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRS 915

  Fly   915 LASGRSLDRKELSIDVL------------------------------HSMAARDVQV-------- 941
            :...:.|||....:..:                              |:.:|..:|.
Zfish   916 IIGSKGLDRSNSWVHTMGCKSAPWGTSPGSTSDTKQAMERSGNRMSSHTESASFLQTLTGRLPTK 980

  Fly   942 RLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLST 1006
            :|.||||||.|||:||...:.|:..:||.|||:|||:|.||:.::.|..|||:|||.:|.||::.
Zfish   981 KLFHEELALQWVVSSGSVREGALQQAWFFFELMVKSIIHHLYFTDRLESPRKNRFPERFMDDITA 1045

  Fly  1007 LVHLVTTKVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASI--PD 1069
            ||..:...:|.....:.:|.:.||.||.||:.|:||:|||||||.|||||.|.:.:|..::  |.
Zfish  1046 LVSTIAGDIVSRFQKDLELVERLNTSLAFFLNDLLSVMDRGFVFTLIKTYWKQVSTKLYALQNPT 1110

  Fly  1070 LMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSL-----ERALHA 1129
            |.:.::|||||||||||:|.|||||    :::|.|.||:||.:|:.||:|..|.     :.|...
Zfish  1111 LESLRLDFLRIVCSHEHYVTLNLPF----SLLTPPASPSPSVSSATSQSSGFSTHVQDQKIANMF 1171

  Fly  1130 DLSQEFLQQHFLVGLVLSDLAAVMEVPNPQ----------LHGKAIRCIRNLMTSHDLDARYSET 1184
            :||..|.:||:|.||:|::||.::|   |:          ||.|.|..:.||::|||.|.||::.
Zfish  1172 ELSVPFREQHYLAGLILTELAVILE---PEADGSVPWMFGLHKKVISVVHNLLSSHDSDPRYADP 1233

  Fly  1185 DARARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGP----HQTITASTINPEVAF 1245
            :.:||||.||:||:.|||:.:||||..   .:.|.|.|:    .||    .:....|.|:..||.
Zfish  1234 EVKARVALLYLPLIGIVMETLPQLHDF---TESLNQWGR----GGPGTEEQEAEGNSMISQTVAM 1291

  Fly  1246 AISG------SRPYSY-LNEQ-VKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRV 1302
            ||:|      |||.|: ||.| .:.....|:|::|.||:|.||||||.:..||.:|..|||..::
Zfish  1292 AIAGTSVPQMSRPSSFLLNPQATRQHGSFSAESSRSLLICLLWVLKNADEMVLQKWFTDLSVSQL 1356

  Fly  1303 HQMLQGVNVCLKTFEY-------TGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYD 1360
            :::|..:.:|:..|||       .|:|   ..:|.|:.:|:|  |.|:|.||||.|.|:..||.:
Zfish  1357 NRLLDLLYLCVSCFEYKAHFLFMQGKK---AFERMNSLTFKK--SKDMKAKLEEAILGSIGARQE 1416

  Fly  1361 LINRRKDR----------NSTEKFRWRKDQMPYRSQYADAVGKSEH------ELELSHFIEGSLA 1409
            ::.|.:.:          .|.|..|||||...:| |.::.:.|.:.      |||....|:|:||
Zfish  1417 MVRRSRGQLERSPSGSAFGSQENLRWRKDMTHWR-QTSEKMDKGQRSVRTRAELEHEAIIDGNLA 1480

  Fly  1410 TEVALVLLDTLEIIVH--AAANLYHNLLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNL 1472
            ||..|::||||||||.  :......::||.||||||||::.|||.|.||:.||:||||:.|||.|
Zfish  1481 TEANLIILDTLEIIVQTVSVTESKESILGGVLKVLLHSMACNQSALYLQHCFATQRALVSKFPEL 1545

  Fly  1473 LFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVG 1537
            ||::||:.||||||.||::|.|.:..||:.|:|||||||||||||||||||||||||||||||||
Zfish  1546 LFEEETEQCADLCLRLLRNCSSSIGTIRAHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVG 1610

  Fly  1538 TSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLD 1602
            ||..|:|:.|||:|||:|.|||.|.:|::|:||:|||||:|||||||||||||||:|||||||:|
Zfish  1611 TSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLID 1675

  Fly  1603 LMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAV 1667
            ||.|||||||.:||||||||:|||.||.||.||.|||.|.||:|:||:|||||||.:|:||||.|
Zfish  1676 LMYRIAKGYQTSPDLRLTWLQNMAGKHSERNNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCV 1740

  Fly  1668 SFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKIL 1732
            :||.||.|.|.||||||||:||.|:|||.|.:|||.||..|||:|:.||.:||||||:|||||:|
Zfish  1741 TFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTEAGLVGLLEQAAASFSMAGMYEAVNEVYKVL 1805

  Fly  1733 IPICEANRDFQKLSKVHGKLQEAFNRI-SQLQG-KRVFGTYFRVGFYGGKFGDLDQQEFIYKEPT 1795
            |||.|||||.:||:.:||||||||.:| .|..| :|:|||||||||||.||||||:|||:||||.
Zfish  1806 IPIHEANRDAKKLATIHGKLQEAFGKIVHQSTGWERMFGTYFRVGFYGSKFGDLDEQEFVYKEPA 1870

  Fly  1796 LTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETY 1860
            :|||.||..||::||.||||.|.|.:|||||.||...|||:||:||||||||||:||||:.|.||
Zfish  1871 ITKLAEISHRLESFYGERFGEDQVEVIKDSNPVDKCKLDPNKAFIQITYVEPYFDTYEMKDRITY 1935

  Fly  1861 FERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVA 1925
            |::|:|::||:|.||||.:|:|||:|:||.||||||||::.|||:||||.:|.:::|:..|||||
Zfish  1936 FDKNYNLRRFVYCTPFTLDGRAHGDLHEQFKRKTILTTSHAFPYIKTRINIIHKEEIISTPIEVA 2000

  Fly  1926 IEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNK 1990
            |||:||||.|||.||:|:|:|.|:|||||||.:||||||||:|:|.||||.:.....: .:|.||
Zfish  2001 IEDMQKKTQELAFATHQDPSDAKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKL-YRHHNK 2064

  Fly  1991 LRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPFITLTSVQNH-GVVKANA 2054
            |||||::|:|||.|||:||::||..|||:||||||||..|..|.|.|.|.....|.: .|::.|:
Zfish  2065 LRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKPVLQVNS 2129

  Fly  2055 YNN 2057
            :.:
Zfish  2130 HRD 2132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	29/97 (30%)
		C2_Dock-C	589..769	CDD:176078	104/179 (58%)
		DHR-2	1549..2037	CDD:284365	332/489 (68%)
dock7	XP_021332839.1	DUF3398	68..158	CDD:314708	29/97 (30%)
		C2_Dock-C	558..735	CDD:176078	104/179 (58%)
		DHR2_DOCK7	1648..2122	CDD:212576	319/474 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583544
Domainoid	1	1.000	746	1.000	Domainoid score	I96
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23566
Inparanoid	1	1.050	1913	1.000	Inparanoid score	I56
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm24579
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	O	PTHR23317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5567
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800