Protein Alignment Zir and dock4a

DIOPT Version :10

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_005170755.2
• Gene: dock4a / 566115
• ZFINID: ZDB-GENE-090112-1
• Length: 1925
• Species: Danio rerio
• Alignment Length: 2201
• Identity: 388/2201 - (17%)
• Similarity: 688/2201 - (31%)
• Gaps: 853/2201 - (38%)

  Fly    35 PSLCGSSISPTEPLD--YEEFLSQHMNIINRDPLKHILDFPQGDVTVK------------IIPRK 85
            |...|.::...|..:  |..|::::.|:      |.|  ||...:.:|            :||
Zfish    26 PLEIGDTVQILEKCEGWYRGFITKNPNV------KGI--FPSSYIHLKNAHVKNKGQFETVIP-- 80

  Fly    86 IRTVDHVVPN-----------------ENLSDLPHHVQECVNCYTRPWKVVEYAQR----HLSS- 128
              |.|.|:..                 .|..||.|.:...:|      :::|..|:    ||:.
Zfish    81 --TEDSVITEITMTLRDWGTMWKQLYMRNEGDLFHRLWHVMN------EILELRQQVLVGHLTHD 137

  Fly   129 -----SCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSESCTPSSRQSIASLASVSSCT 188
                 ..:|..|:|.|       .::..:|
Zfish   138 RLSDIKQHITARLDWG-------NEQLGLD----------------------------------- 160

  Fly   189 DTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPESEAEENIE 253
              |.||..::..|    .:|..|..|...:...|      .||:...|.:|..|:.:.:
Zfish   161 --LVPRRDFSMVD----PDDISITELYRLMERRH------RRREAPPQASLHHLFLQMK------ 207

  Fly   254 RRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSL-KRML 317
                              :.:...|..|:|..|   ::||::|.:.|||.|:..:|...| |...
Zfish   208 ------------------SMMSSSLGEELEVFF---SVYDSREMRPISERFFVRLNKQGLPKSPE 251

  Fly   318 SSHVQC---ADI-STQSHSAIFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLKEDKDKYREKVK 378
            .:..||   .|: |:.....::.:::       :.|:.:::.|:                ::.|.
Zfish   252 KTERQCTLFVDLGSSDLRKDVYVVAH-------IFRIGRMVAGE----------------KKNVS 293

  Fly   379 SNAVDYCERLGKYRMPFAWTGIYLTNVFNGD------------NFESK-----DAGAAERDSFGN 426
            |.         :|:.|:....|.:.::...|            |.||:     |:...:..|..:
Zfish   294 ST---------QYKRPYGCAVISVADLLTADFKDDHLLKIYSCNAESEWYQIHDSIIRKVSSRYS 349

  Fly   427 ACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENF 491
            ..||:.|...|...|.     ...:|:|:   |.....||..|:.::.        .|::::
Zfish   350 HIGSNTGLNVSLQLLH-----GDMEQIRK---DYMRLFTRNVSITKRL--------GFSDII--- 395

  Fly   492 RPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPE 556
                                                      |||.:
Zfish   396 ------------------------------------------IPGEM------------------ 400

  Fly   557 LAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGS-ARNIAVRVQLMA 620
                                             ||.|:|:.:...|.....| |||:.|.|.|:.
Zfish   401 ---------------------------------RNDLYVTLERGEFEKGGKSVARNVEVTVYLLG 432

  Fly   621 --GETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVS 683
              |:..|..|....|:...    .|..:.|.||:..|.:.::||:.:|..:.:..||.|.:.|.|
Zfish   433 ADGQLLKGLVCCGSGEPGV----DEHHSFVLYHSNSPRWAEQIKLPIPLEMFRGTHLRFELRHCS 493

  Fly   684 CQKKPQDLQPSVETPIGYTWLPLL-EDGK-LKFGEFNLPV--------------MVESPPENYSF 732
            .::|.:      :...|::::||: :||: |..|...|.|              .::.|....|.
Zfish   494 TKEKGE------KKLFGFSFVPLMQDDGRPLPDGTHELIVHKCEETADLQDLARYLKLPFSKASL 552

  Fly   733 IPPNVHLPGIKWLDNHRAVFSINVEAVTAIHTLDSFLDRFFLICEYLDTRNIPSHIGENNIETEL 797
            .|.|                         ..|:.:..:.|::......|:     :.:|....:|
Zfish   553 QPGN-------------------------NQTIKNSKESFWIQSSLCSTK-----LTQNGDMLDL 587

  Fly   798 KK----------CLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVS 852
            .|          ||..::..:...:|:.|...||.|..:|      .......|..||:  |||
Zfish   588 LKWRVHPDRIIDCLSKLKDIDGTEIVKFLQDTLDTLFGIL------DESPQRYGLKVFD--CLV- 643

  Fly   853 SLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDLQLSESYTIYDNVL 915
            .::::|.|.::..:  :.::..|:  ||...:              |..:.:::.:.|
Zfish   644 HVINLLQDSKFQLF--KPVMDNYIENHFAGAL--------------SYRDLIRVLKWY------- 685

  Fly   916 ASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWFLFELIVKSMIE 980
                 :||   .||..|....:.|                        :..|.:||:.||:|  .
Zfish   686 -----VDR---IIDAEHQEQIQQV------------------------LKASEYLFKYIVQS--R 716

  Fly   981 HLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLGFFI--FDILSI 1043
            .|:.:.| .|..:..|....: :|...:||       :.|:|.|....:..:...|:  |..:|.
Zfish   717 RLYAAAT-GGQNEEEFRCSVH-ELFKSIHL-------FLSHESKGISPITHTQAVFLRSFPTVSC 772

  Fly  1044 MDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFGTSYTMVTAPCSP- 1107
                   .|:|.:         |:.::.|...|.|.           :||   :.|....|..|
Zfish   773 -------ELLKIF---------SMREVANVARDTLN-----------SLP---TLTHTDCPLQPV 807

  Fly  1108 --------TPSTTSSNSQTSCGSLE---RALHADLSQE------------FLQQHF--------- 1140
                    ..|...:|:::.|..|.   |.||..|.::            .|..|.
Zfish   808 KLQCMAKTVESPLYTNTESRCVLLPVVLRLLHTHLQEQRELVLCANILSSMLTLHTPATDCGVSD 872

  Fly  1141 LVGLVLSDLAAV-----MEVPN-PQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLS 1199
            .|.||:..|:.|     :||.| ||....::|            .:|.  |......|..:.||.
Zfish   873 EVNLVMESLSGVLLRTILEVTNRPQPSASSLR------------LQYQ--DVTGEFVACLLTLLR 923

  Fly  1200 IVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKL 1264
            .:.|                     ::||                              |:.::.
Zfish   924 QLKD---------------------KEYQ------------------------------QLLSRF 937

  Fly  1265 PLSSENTRHLLVCFLWVLKNLERNVLYRWLM--DLSPHRVHQM-LQGVNVCLKTFEYTGQKNVAT 1326
            |...|.|..||..|          .::|.|:  |:.|.....| |...||.:.|..|
Zfish   938 PTKDELTSFLLQLF----------TVFRILIRPDMFPKDWTVMRLVANNVIITTILY-------- 984

  Fly  1327 LKRTNTQSFRKTGSTDVKEKLE---------ECIRGTNS--ARYDLINRRKDRNSTEKFRWRKDQ 1380
            |..|...||       :.||.:         .||...|.  .:.::....|.:...||:
Zfish   985 LSDTLRNSF-------LNEKFDFKVWESYFYLCIIFINQPCLQLEMFPPSKRKKVLEKY------ 1036

  Fly  1381 MPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAAANLYHNLLGTVLKVLLHS 1445
                                     |.:...:...:....:.:.....||...|:|..::|.|..
Zfish  1037 -------------------------GDMRVMIGCEIFSMWQHLGDYKLNLIPTLIGPFMEVTLVP 1076

  Fly  1446 LSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLL 1510
            ....::||               .|  :|.|..|            |.....|
Zfish  1077 QMDLRNVL---------------IP--IFHDMMD------------CEQRRSG------------ 1100

  Fly  1511 MRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQD 1575
                     ||.:|:.::...|..|:....  .:::.|.....::.
Zfish  1101 ---------NFKQVEAKLIDKLDGLMSEGK--GDETYRELFNNIIP------------------- 1135

  Fly  1576 LLFNLHMILSDTVKMKEYQED-----------PEMLLD--------------------LMNRIAK 1609
             ||..:..|...::.:.::|.           .|.|||                    |:| ..|
Zfish  1136 -LFGPYPSLLKKIERETWRESGVSHIATVTRLMERLLDYRDCMKIGEVDGKTMGCTVNLLN-FYK 1198

  Fly  1610 GYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASLVS-------EYLSM-LESQKHLPVGA 1666
            ...|..::.:.::..:.:.|.:..|:|||:...:....|:.       |:||. ::|:
Zfish  1199 TELNKEEMYIRYIHKLYELHLKAQNYTEASYTLLLYDELLEWTERPLREFLSYPMQSE------- 1256

  Fly  1667 VSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKI 1731
              :||       :..:...::...:.|.|..|..      .|..|.:|.:
Zfish  1257 --WQR-------KECLHLTIIHNFDRGKCWENCI------ILCRELANQY--------------- 1291

  Fly  1732 LIPICEANRDFQKLSKVHGKLQEA--FNRISQLQGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKE 1793
                 ||..|::.|||:  ::.||  :::|...|  |:...:|||||||.||. .|..:||:.:
Zfish  1292 -----EAYYDYRNLSKM--RMMEASFYDKIMNQQ--RLEPEFFRVGFYGKKFPFFLRNKEFVCR- 1346

  Fly  1794 PTLTKLPEIFSRLQNFYTERFGPDSVHII--KDSNTVDINSLDPDKAYIQITYVEPYFETYEMRH 1856
                  ...:.||:.| .:|...:..|.|  :.:|..|......|..|:||..|.|..|..::..
Zfish  1347 ------GNDYERLEAF-QQRMLSEFPHAIAMQHANQPDQTIHQADAQYLQIYAVSPVPENQDVLQ 1404

  Fly  1857 RE-------TYFERNFNIKRFIYATPFTKNGK-AHGELNEQCKRKTILTTANHFPYVKTRIMVIS 1913
            |:       ::::.| :|.||.|..||.|..| ...|.......:|.||.|...|.:.....|..
Zfish  1405 RDGVPNNIKSFYKVN-HIWRFRYDRPFHKGTKDKENEFKSLWVERTTLTLAQSLPGISRWFEVEK 1468

  Fly  1914 RQQIVLEPIEVAIEDIQKKTLEL----AAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASVFL 1974
            |:.:.:.|:|.|.|.|:.|||:|    |....::..:...|.|.|.|.|...||.|.......|.
Zfish  1469 RELVEMSPLENASEVIENKTLQLRTLIAQCQMRQMLNINPLTMCLNGVIDAAVNGGLARYQEAFF 1533

  Fly  1975 ------SNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQREL 2024
                  ::..||..:     .:||....|.:......|..:...:..|.|...::|
Zfish  1534 AKDYIANHPEDGEKI-----TRLRELMFEQAHILEFGLAVHEKFVPQDMKPLHKKL 1584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DOCK_C-D_N	46..153	CDD:463380	27/147 (18%)
		C2_Dock-C	589..769	CDD:176078	44/198 (22%)
		DHR2_DOCK_C	1614..2035	CDD:212568	102/442 (23%)
dock4a	XP_005170755.2	None