Protein Alignment Zir and DOCK10

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_016859930.1
• Gene: DOCK10 / 55619
• HGNCID: 23479
• Length: 2245
• Species: Homo sapiens
• Alignment Length: 2320
• Identity: 638/2320 - (27%)
• Similarity: 1018/2320 - (43%)
• Gaps: 535/2320 - (23%)

  Fly    46 EPLDYEEFLSQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPN------ENLSDLPHH 104
            ||||||..:.:.......|||:.:|.||..|.:...:...|||:...||.      |||.
Human    62 EPLDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLL----- 121

  Fly   105 VQECVNCYTRPWKVVEYAQRHLSSSCYIRERIDRGTISPSAY-QQEFEI-------DKDFSS--- 158
            |:|....|:..|.||.|.....|..  ||: :.|....|... ...|||       |:|.:|
Human   122 VKEACKFYSSQWHVVNYKYEQYSGD--IRQ-LPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSS 183

  Fly   159 ------------FEEAFAYKSE-SCTPSSRQSIASLAS--------------------------- 183
                        |:..:.||.. :.|.::..::.|...
Human   184 SKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEP 248

  Fly   184 -----VSSCT---------------------------DTLTPRGSW-------------ASFDLR 203
                 :.|||                           :|.:....|             .....|
Human   249 KGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGR 313

  Fly   204 RSVN------DPLIPNLLDNVPPEHIDQSN------------------EARRQQDRQMALFSLYP 244
            ||..      |.|..::.....||..|.|.                  :..|..:| :.||||.|
Human   314 RSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMER-LNLFSLDP 377

  Fly   245 ESEAEENIERRLLAEIPV-----EHMGHRIQVNCLQLRLELE-------------VEPIFASMAI 291
            :.:..:..::.||....|     |....||.:.|..|...|:             :||.|.|:|:
Human   378 DIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNIEPFFVSVAL 442

  Fly   292 YDAKERQKISENFYFDMNADSLKRML---SSHVQCADIST-------QSH-------------SA 333
            ||.::.:|||.:|:.|:|..::::||   |..::..:|.|       :.|             .|
Human   443 YDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQA 507

  Fly   334 IFEISYPSNDLFLVIRLEKVLQGDINNSVEPYLKE-DKDKYREKVKSNAVDYCERLGKYRMPFAW 397
            :|.:|.|.:::.||.::||||.|:|.:..|||:|. |.:||.:|:..:...:|.:||||||||||
Human   508 VFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAW 572

  Fly   398 TGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSG 462
            .   :.:||              :|:.||              :||.|
Human   573 A---VRSVF--------------KDNQGN--------------VDRDS----------------- 589

  Fly   463 TLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSV 527
                                       .|.|:       |:||:.|:..|||.|::.:.:|...:
Human   590 ---------------------------RFSPL-------FRQESSKISTEDLVKLVSDYRRADRI 620

  Fly   528 MKKYKCIPGSIKLEISPCVEEAKNALTPELAPINP-QSADNVRPVKEILEFPQSAIYN------P 585
             .|.:.||||:.:.:.....|..|.:|....|:.| .......|..|:.||    :|:      |
Human   621 -SKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEF----VYDSTKYCRP 680

  Fly   586 HYSYRNLLFVSPKELNFSSRA--GSARNIAVRVQLM-AGETPKDAVNAIYGKSSCPKFSTEAFTA 647
            :..|:|.:::.||.|.:.|:.  ..||||.|.::.. :.|.....:..||||...|.|::.|:||
Human   681 YRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTA 745

  Fly   648 VNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQ---KKPQDLQPSVETPIGYTWLPLLED 709
            |.:|::.|.|.||:||.||..:.:.||:||:.|||:|.   |.....:.::||.:||.||||::.
Human   746 VLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKH 810

  Fly   710 GKLKFGEFNLPVMVESPPENYSFIPPNVHLPG---IKWLDNHRAVFSINVEAVTAIHTLDSFLDR 771
            .::...|:|:|:....||...||........|   |||:|..:.:|.::...|:.::|.|..::.
Human   811 DQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNA 875

  Fly   772 FFLICEYLDTRNIPSHIGENNIETELKKC--LLDIEYANREPLVRHLPLVLDKLIELLVVTHKVG 834
            ||..|:..:     ..:.::.....::.|  ||::|..:  .::..||::|::|.::|     |.
Human   876 FFQECQKRE-----KDMSQSPTSNFIRSCKNLLNVEKIH--AIMSFLPIILNQLFKVL-----VQ 928

  Fly   835 GQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPHPFQSKQRLTCSRSTT 899
            .:...:.:||..||   :.:::..:::|.|.     .:.:|:.|..|
Human   929 NEEDEITTTVTRVL---TDIVAKCHEEQLDH-----SVQSYIKFVFK------------------ 967

  Fly   900 EDLQLSESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADL-- 962
                                                .|..:.|.:|||||.: |....|:.|.
Human   968 ------------------------------------TRACKERTVHEELAKN-VTGLLKSNDSTT 995

  Fly   963 ---AMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPK 1024
               .:.:|||.|.:|:|||.:||..:|.:..||..|||..:.::|..||.:::..|:..:.:..:
Human   996 VKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSDHVIWKYKDALE 1060

  Fly  1025 LAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVA 1089
            ..:..|.|:..|:....:.||||:||.::..|..:..|  ..:..|..||.|||:.||.||||:.
Human  1061 ETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSS--GDLKTLCQYKFDFLQEVCQHEHFIP 1123

  Fly  1090 LNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHA------DLSQEFLQQHFLVGLVLSD 1148
            |.||       :.:...|.|.|.|.::|        .|||      .::.||.::|||:|::|.:
Human  1124 LCLP-------IRSANIPDPLTPSESTQ--------ELHASDMPEYSVTNEFCRKHFLIGILLRE 1173

  Fly  1149 LAAVMEVPNPQLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQLHQHGL 1213
            :...::......| .|:..::|||..|..|.||.|...:|::|:||:||..:::|.:|:::...|
Human  1174 VGFALQEDQDVRH-LALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYGMLLDNMPRIYLKDL 1237

  Fly  1214 -----------EQDRLQQIGQLEDYQ--------------------GPHQTITASTIN---PEVA 1244
                       .:|.|...|..:...                    ....:|..||:|   ...:
Human  1238 YPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLNSIAAFSSIAISTVNHADSRAS 1302

  Fly  1245 FAISGSRPYSYLNEQVKNKL--------PLS------------SENTRHLLVCFLWVLKNLERNV 1289
            .|...|.|.:  ||:...|.        |||            ...||.||:|||.::|.:....
Human  1303 LASLDSNPST--NEKSSEKTDNCEKIPRPLSLIGSTLRFDKLDQAETRSLLMCFLHIMKTISYET 1365

  Fly  1290 LYR-WLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNV-----------------ATLKRTNTQSFR 1336
            |.. |....|| .|......::|||:.|.|.|::|:                 .|||.:|.
Human  1366 LIAYWQRAPSP-EVSDFFSILDVCLQNFRYLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNP---- 1425

  Fly  1337 KTGSTDVKEKLEECIRGTNSARYDLINRRKDRNSTEKFRWRKDQM--PYRSQYAD-AVGKSEHEL 1398
               |......|.:.:..|:|..    ..::.|:.|......|:.:  |...|..| .:..:.:|:
Human  1426 ---SCQTSGLLSQWMHSTSSHE----GHKQHRSQTLPIIRGKNALSNPKLLQMLDNTMTSNSNEI 1483

  Fly  1399 ELSHFI--EGSLATEVALVLLDTLEIIVHA------AANLYHNLLGTVLKVLLHSLSRNQSVLAL 1455
            ::.|.:  |.::||||.|.:||.|.:....      ..:..::|:..|....:.....|||..||
Human  1484 DIVHHVDTEANIATEVCLTILDLLSLFTQTHQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATAL 1548

  Fly  1456 QNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEIG-- 1518
            :::|||.|..:.|||:..|....|:|...|..:||.|.......:::|:|.||..||:|||..
Human  1549 KHVFASLRLFVCKFPSAFFQGPADLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQ 1613

  Fly  1519 NNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHMI 1583
            .:..|..:|:..::|.|:..:.:...: .:.:|.....:|..|..:::::||.:|:||...:..:
Human  1614 KSIVRSHLQLIKAVSQLIADAGIGGSR-FQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTV 1677

  Fly  1584 LSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAASL 1648
            |..|.:|||:::|||||:||...:|..|.:.|:||.||||:|||.|....:.:||||||:|.|:|
Human  1678 LMATAQMKEHEKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAAL 1742

  Fly  1649 VSEYL--------------SMLESQKH----------------LPVGAVSFQRISPNTLMESAVS 1683
            ::|||              |:|....|                ..:|..:|..|:||...|.|:.
Human  1743 IAEYLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMK 1807

  Fly  1684 DDVLSPGEDGICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKV 1748
            :|  |..:|     ..:.|..|...|.........:..||.:.:|.|.:|.:.|..|||:|||.:
Human  1808 ED--SGMQD-----TPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDL 1865

  Fly  1749 HGKLQEAFNRISQL--QGKRVFGTYFRVGFYG-GKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFY 1810
            :..:..::.:::::  ..||:||.|:||.||| |.|.:.:.:|:|||||.||.|.||..||...|
Human  1866 YYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLY 1930

  Fly  1811 TERFGPDSVHIIKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATP 1875
            .::||.|:|.||:|||.|:...|||..||||:|||.|:||..|:..|:|.||.:.||.||::.||
Human  1931 ADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFETP 1995

  Fly  1876 FTKNGKAHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAAT 1940
            ||.:||.||.:.|||||:|||||::.|||||.||.|||:....|.||||||:::.||..||....
Human  1996 FTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKVSELNQLC 2060

  Fly  1941 NQEPADPKILQMVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFREFSKRCADA 2005
            ..|..|...||:.|||.:...||.|||..|..||.. ::....|......|:..||:|:..|..|
Human  2061 TMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEE-TNAKKYPDNQVKLLKEIFRQFADACGQA 2124

  Fly  2006 LKKNRNLILSDQKDYQRELERN-NDRFIERLTPFITLTSVQNHGV 2049
            |..|..||..||.:||.||..: .|...|       |::|.|..|
Human  2125 LDVNERLIKEDQLEYQEELRSHYKDMLSE-------LSTVMNEQV 2162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	27/98 (28%)
		C2_Dock-C	589..769	CDD:176078	64/188 (34%)
		DHR-2	1549..2037	CDD:284365	204/521 (39%)
DOCK10	XP_016859930.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149368
Domainoid	1	1.000	61	1.000	Domainoid score	I10448
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D20156at2759
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.660