Protein Alignment Zir and dock8

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_001920107.4
• Gene: dock8 / 403040
• ZFINID: ZDB-GENE-060503-743
• Length: 2090
• Species: Danio rerio
• Alignment Length: 2152
• Identity: 906/2152 - (42%)
• Similarity: 1321/2152 - (61%)
• Gaps: 216/2152 - (10%)

  Fly     2 SSAQRSFVQKVSKQSAADVRKNVSGC---------HLSKAMDPSLC---GSSISPTEPLDYEEFL 54
            :|.:|:|..|:::.|:|::|::.||.         |...| ..|.|   ..|....||:|.:|||
Zfish     6 ASERRAFALKINRHSSAEIRRHFSGVSHGSLPHHRHSYNA-SGSFCFNVPQSYEAVEPVDLDEFL 69

  Fly    55 SQHMNIINRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVV 119
            ...:...:.:.::.:.:||..|:.|:::.|:.||:...:..|.: :|..||::||..||:||.||
Zfish    70 MSQLRSGDAEVMQELGEFPDDDLDVELVERECRTIRPTIAEEGV-ELDSHVRDCVQSYTQPWLVV 133

  Fly   120 EYAQRHLSSSCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSESCTPSSRQSIASLASV 184
            ....:......| .:|.|...|   ..:|.||.|                ..|..::.:....|:
Zfish   134 SRRSQGYGWISY-SDRTDSNKI---LQRQTFESD----------------VQPDKQEQLDKSPSL 178

  Fly   185 SS-CTDTLTPRGSWASFDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPESEA 248
            :: |.|:.....:.:.|:||....|..:.::|....||.:|:.|:..||.:|...||.|||..:.
Zfish   179 TALCDDSARTTLTSSDFNLRALQPDQRVESVLRFSSPEELDRFNQESRQSNRYGELFGLYPPIDE 243

  Fly   249 EENIERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSL 313
            |:.:..|.:.:.|.||.|.||.|.|..::.|:|:||:||:||:||.||::||||||.||:|:|.:
Zfish   244 EDAVAIRPIPDCPKEHFGQRILVRCQTVKFEIEIEPLFATMALYDLKEKKKISENFNFDLNSDQM 308

  Fly   314 KRMLSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPY--LKE-DKDKYR 374
            |..|.:|....|.||.|.||||.|||||.|::|||::|||| ||:|.:..|||  ||| |..|.|
Zfish   309 KGFLRTHTPQVDTSTLSRSAIFSISYPSPDIYLVIKIEKVLQQGEIGDCAEPYMVLKESDTTKNR 373

  Fly   375 ---EKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAP 436
               ||:::.|..:|:|||:||||.|:..:.:.:|.|
Zfish   374 DKLEKLRNQAEGFCQRLGRYRMPLAFATVNIMSVIN----------------------------- 409

  Fly   437 SSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSF 501
              ::|:|:  ||..|.:..:     |::.::|...|.....|...|::  ::..|:| .:|:.:|
Zfish   410 --STLERE--TSDTDSINGR-----GSMDKKGLPRRNSDRFSLMEDNY--ILSGFKP-AVTMCTF 462

  Fly   502 FKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSAD 566
            .|||.:::.||||:|.|.::||.|| .::.|.|||.:|||:.|..:.....|:|||.|:.|.|..
Zfish   463 IKQEGERLSDEDLFKFLADIKRSSS-QRRVKIIPGYLKLEVLPAPDTVPGCLSPELIPVKPVSEK 526

  Fly   567 NVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETPKDAVNAI 631
            |.||:||:||||...:|.||..|||||:|.|..||.::|..|||||.|::|.|:||....|:..|
Zfish   527 NQRPIKEVLEFPSKEVYVPHNIYRNLLYVYPLRLNLTNRLTSARNITVKIQFMSGEDSSCAMPVI 591

  Fly   632 YGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVE 696
            :||||.|:|.||.:|.|.|||:.|.|||||||.|||.:...||||||.:|:|||:| |:...|||
Zfish   592 FGKSSGPEFLTEVYTPVTYHNRSPDFYDEIKILLPARLTDKHHLLFTFFHISCQQK-QNQTGSVE 655

  Fly   697 TPIGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPN---VHLPGIKWLDNHRAVFSINVEA 758
            ..|||:|||:|.:.:|:..:..||::::..|.|||...|.   ..:|.:|||:||:.:|::.::|
Zfish   656 ALIGYSWLPMLNNDRLQTSQQCLPIVLDKLPINYSLHTPEKLPAQVPPVKWLENHKGLFNLELQA 720

  Fly   759 VTAIHTLDSFLDRFFLICEYLDTRNI------PSHIGENNIETELKKCLLDIEYANREPLVRHLP 817
            |:::.|.||.|:|||.:|..|:.::.      ...|.||..|.|||..::.:..|..||||..|.
Zfish   721 VSSVQTQDSHLERFFTLCHALEGKSTFPIRVRDEKIQENMFEHELKLSIISLSSAGLEPLVLFLH 785

  Fly   818 LVLDKLIELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQY--DQYGRQSLLSTYVHFQC 880
            .|||||..|::....:.||..:|....||  .:||.:.|:.|..:.  |..||..||:||::|..
Zfish   786 QVLDKLFRLIMQPMVIAGQTANLAQIAFE--SVVSVINSLHNSQELAKDHQGRNCLLATYLYFVF 848

  Fly   881 KIP----------------HPFQSKQRLTCSRSTTEDLQLSESY-----------------TIYD 912
            ::|                ||......||.:.:||....|.:|.                 |..:
Zfish   849 RLPDTQYEIHTSGTGGLMAHPEGRYSTLTRTTATTVGFMLLQSRIRSSSNPDIPAPLSPEDTEVN 913

  Fly   913 NVLASGRSLD----RKELSIDVLHSM-----AARDVQVRLLHEELALHWVVASGKAADLAMSNSW 968
            |:|  |:.|:    |...:.:..:|.     :.|....:|.||||||..||::|...:.....:|
Zfish   914 NIL--GKVLNHPGSRMSTAANASNSPQSSTGSTRPTNKKLFHEELALQMVVSTGVCRENVYKYAW 976

  Fly   969 FLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTK---VVGYHSNEPKLAQSLN 1030
            |.||::||||.:|:...:.....|::||..:|.||::|:|::||.:   ::.....|.:.|:.:|
Zfish   977 FFFEVLVKSMSQHVSQLDKKTVSRRNRFSDRFKDDITTIVNVVTAEIGNILVKQQKELEQAEKVN 1041

  Fly  1031 ASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNYKIDFLRIVCSHEHFVALNLPFG 1095
            .||.||::|::|:|||||||.|:|.|...:.:|:.::..|::.:::|||::|||||::.|:|.|.
Zfish  1042 ISLAFFLYDLMSLMDRGFVFQLVKNYCNQMAAKSVNMATLISMRLEFLRVLCSHEHYLNLSLFFS 1106

  Fly  1096 TSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHA--DLSQEFLQQHFLVGLVLSDLAAVMEVPNP 1158
            :.   .:||.||:|| .||.:.:||...:..:.|  ||||:|.|:|:|.||:|::|:..:::.:.
Zfish  1107 SP---SSAPASPSPS-VSSQTSSSCSFQDNKIAAMFDLSQDFKQRHYLTGLLLTELSTALDIESE 1167

  Fly  1159 --QLHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIPLLSIVMDCIPQL------------H 1209
              ::..|||....:|:.:||||.|.|.::.:|::||||:||:.|::|.|..|            .
Zfish  1168 GGRVQQKAINATYSLLCAHDLDQRCSRSEVKAKIAALYLPLVGIIIDSINYLDFTVSDSRSGKGK 1232

  Fly  1210 QHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNE---------QVKNKLP 1265
            ..|.|:|             |.   ..:|||..||.||:|: |::.|..         .||....
Zfish  1233 SGGPEED-------------PD---NIATINQSVAMAIAGN-PFNTLTRNALVSMASVSVKTTNM 1280

  Fly  1266 LSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRT 1330
            |::|.:|:||:||||::||.::|::.||.:|:...::.::|:.:.:|...|||.|::   :..:.
Zfish  1281 LTAETSRNLLMCFLWIIKNADQNLIQRWTVDMPSSQLSRLLELLAICTSCFEYRGKQ---SSDKV 1342

  Fly  1331 NTQSFRKTGSTDVKEKLEECIRGTNSARYDLINR----RKDR--NSTEKFRWRKDQMPYRSQYAD 1389
            :||:.:|  |...|.:|||.:.|...||.:::.|    ..||  ...|..|||||...:| |..|
Zfish  1343 STQALQK--SQQAKARLEEALLGGIGARGEMMKRVGVQGNDRTLGLRENLRWRKDLTQWR-QTND 1404

  Fly  1390 AVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA--ANLYHNLLGTVLKVLLHSLSRNQSV 1452
            ...||:.||:....|.|:||||..|::||.||:||.|.  |:...|::|.|||||||||:.|||.
Zfish  1405 RQDKSKAELDQEAIISGNLATETNLIVLDLLEMIVQAVPLADCKDNVVGGVLKVLLHSLTCNQST 1469

  Fly  1453 LALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLYLLMRQNFEI 1517
            ..|.:.|::.||||.||.:|||::|.:.|||||..:|.:|.|.:.|.||||.|:|||:||.::..
Zfish  1470 TYLSHCFSTLRALIVKFGDLLFEEEAEQCADLCQKVLHYCSSCVDGNRSQACATLYLIMRYSYSS 1534

  Fly  1518 GNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQVQDLLFNLHM 1582
            .:||:||||||||||:||||.||...|:.|||:.:|:|.|||.|:::|.|..|.||.:||.||:.
Zfish  1535 ASNFSRVKMQVTMSLASLVGKSSDIHEEYLRRSFRTILAYAEEDTEMQSTQLPSQVDELLRNLNS 1599

  Fly  1583 ILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEAAMCYVHAAS 1647
            ||||||||||:|:|||||:|||.|||||||.:||||||||:|||:||..|...||:|||.||||:
Zfish  1600 ILSDTVKMKEFQKDPEMLMDLMYRIAKGYQTSPDLRLTWLQNMAEKHNGRKCFTESAMCLVHAAA 1664

  Fly  1648 LVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTETGLKALLEEA 1712
            ||:|||||||..|:||||:|:||.||||.|.|||||||:|||.|||:|.|.:|||.||..|||:|
Zfish  1665 LVAEYLSMLEDHKYLPVGSVTFQNISPNVLEESAVSDDILSPDEDGVCSGRYFTENGLVGLLEQA 1729

  Fly  1713 SNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRISQLQGKRVFGTYFRVGFY 1777
            :..|...|::||:|||||:::||.||:|||:||:..|.|||.||:.|.|...||:||||||||||
Zfish  1730 AELFSNGGLFEAVNEVYKVIVPILEAHRDFRKLASTHDKLQRAFDNIIQKGHKRMFGTYFRVGFY 1794

  Fly  1778 GGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDINSLDPDKAYIQI 1842
            |.||||||:||||||||.:|.||||..||:|||::.||...:.:||||..||.|.|.|:||||||
Zfish  1795 GSKFGDLDEQEFIYKEPGITHLPEISHRLENFYSQCFGDGVLEMIKDSTPVDRNKLSPNKAYIQI 1859

  Fly  1843 TYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTILTTANHFPYVKT 1907
            |:|||||:.|||:.|.|.||:|||::||:|.|||||:|:..||||||.||||||||.:.|||:||
Zfish  1860 TFVEPYFDDYEMKDRLTNFEKNFNLRRFMYTTPFTKSGRPRGELNEQYKRKTILTTMHAFPYIKT 1924

  Fly  1908 RIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTTVNQGPMEMASV 1972
            ||.||.:::..|.||||||||:||||.|||.||::|..|..:|||||||.:..||||||:|:|.|
Zfish  1925 RINVIQKEEFDLTPIEVAIEDMQKKTRELAEATHREKPDAVMLQMVLQGSVTATVNQGPLEVAQV 1989

  Fly  1973 FLSNLSDGTTVPT-----KHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELERNNDRFI 2032
            ||:.      :|.     :|.|||||||:||..||.:|::||:.||..|||:||:|:::|.::..
Zfish  1990 FLNE------IPADPKLFRHHNKLRLCFKEFILRCGEAIEKNKQLITPDQKEYQQEMKKNYNKLR 2048

  Fly  2033 ERLTPFI 2039
            |.|.|.:
Zfish  2049 ENLRPML 2055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	24/91 (26%)
		C2_Dock-C	589..769	CDD:176078	88/182 (48%)
		DHR-2	1549..2037	CDD:284365	304/492 (62%)
dock8	XP_001920107.4	DUF3398	75..161	CDD:288711	24/90 (27%)
		C2_Dock-C	549..731	CDD:176078	88/182 (48%)
		DHR2_DOCK8	1630..2051	CDD:212574	261/426 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583546
Domainoid	1	1.000	746	1.000	Domainoid score	I96
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1913	1.000	Inparanoid score	I56
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm24579
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	O	PTHR23317
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5567
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800