Protein Alignment Zir and Dock6

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_038937778.1
• Gene: Dock6 / 367039
• RGDID: 1306517
• Length: 2123
• Species: Rattus norvegicus
• Alignment Length: 2185
• Identity: 988/2185 - (45%)
• Similarity: 1363/2185 - (62%)
• Gaps: 216/2185 - (9%)

  Fly     2 SSAQRSFVQKVSKQSAADVRKNVS-----GCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNII 61
            :|.:|:|..|:::..||:|||.||     ..|.|:....||........||||:|:.|......:
  Rat     3 ASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRSSSSLGVPLTEVIEPLDFEDVLLSRPPEV 67

  Fly    62 NRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEYAQRHL 126
            ...||:.:::||..|:.:...||:.||.:..||.:...|.  .|:..|..|:..|.:|....:||
  Rat    68 EPGPLRDMIEFPADDLELLKQPRECRTTESGVPEDGKLDA--QVRAAVEMYSEDWVIVRRRYQHL 130

  Fly   127 SSSCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSESCTP-SSRQSIASLASVSSCTDT 190
            |::           .||...:.:.|..|..:.  :.|    |..|| ..|.....:.....|:.:
  Rat   131 STA-----------YSPITTETQRERQKGLTC--QVF----EQDTPGDERTGPEDVDDSQHCSGS 178

  Fly   191 L--TPRGSWAS--FDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPESEAEEN 251
            .  |||.|.||  |.||....|.|:|.||:...||.:|:.|||.|:|.|..||.:|||..:.:|.
  Rat   179 PEDTPRSSGASGVFSLRNLAADSLLPTLLERAAPEDVDRRNEALRRQHRAPALLTLYPAPDEDEA 243

  Fly   252 IERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRM 316
            :||....|.|.||.|.||.|.||.|:.|:|:||||.::|:||.:|::|||||||||:|:||:|.:
  Rat   244 VERCSHPEPPREHFGQRILVKCLSLKFEIEIEPIFGTLALYDVREKKKISENFYFDLNSDSVKGL 308

  Fly   317 LSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPY--LKE-----DKDKY 373
            |.:|.....|||.:.||||.::|||.|:|||::||||| ||||:...|||  :||     :|:|.
  Rat   309 LRAHGTHPAISTLARSAIFSVTYPSPDIFLVVKLEKVLQQGDISECCEPYMVMKEADTVKNKEKL 373

  Fly   374 REKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSS 438
             ||::..|..:|.|||:||||||||.::|.|:.:       ..|..:|||      .|.|
  Rat   374 -EKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVS-------SVGPQDRDS------DSEG----- 419

  Fly   439 NSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFK 503
               :|:.:.:.    ||          |||     .:.||:|.|| |....:|||.|:||.:|||
  Rat   420 ---ERRPTWAE----RR----------RRG-----PQDRSYSGDD-ACSFSSFRPATLTVTNFFK 461

  Fly   504 QEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNV 568
            |||:::.||||:|.|.:::||||::::.:.:...:|::|||..|.....|:|||..:.|......
  Rat   462 QEAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKIDISPAPENLHFCLSPELLHVKPYPDPRG 526

  Fly   569 RPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETPKDAVNAIYG 633
            ||.|||||||...:|.||..|||||||.|..||||||.||.||:|||:|.||||....|:..|:|
  Rat   527 RPTKEILEFPAREVYAPHTCYRNLLFVYPHSLNFSSRQGSVRNLAVRIQYMAGEDQSQALPVIFG 591

  Fly   634 KSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETP 698
            ||||.:|:.||||.|.||||.|.||:|.|:.|||.:.::|||.||.||||||.:|   ..::|||
  Rat   592 KSSCSEFTREAFTPVVYHNKSPEFYEEFKLRLPACVTENHHLFFTFYHVSCQPRP---GTALETP 653

  Fly   699 IGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVEAVTAIH 763
            :|:||:|||:.|:|:.|.|.|||.|:.||.:||.:.|:|.|||::|:|.|:.|||:.:.||:::|
  Rat   654 VGFTWIPLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVH 718

  Fly   764 TLDSFLDRFFLICEYLDTRNIP-----SHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKL 823
            ..|..||:||.:...|:....|     :.:.|..:|.||:..|..:..|:.||||.....|||||
  Rat   719 PQDPHLDKFFTLVHVLEEGIFPFRLKETVLSEGTMEQELRASLAALRLASPEPLVAFSHHVLDKL 783

  Fly   824 IELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIPH---- 884
            :.|:|....:.||.::||...||.:..|:||:....:...|..|...||:.|||:..::|.
  Rat   784 VRLVVRPPVICGQMVNLGRGAFEAMAHVASLVHRNLEAVQDSRGHCPLLAAYVHYAFRLPGGDLG 848

  Fly   885 -----PFQSKQRLTCSR-----------------STTEDLQ------------------LSESYT 909
                 |..:.|..|.:|                 |:..||.                  :..|::
  Rat   849 LPGEVPPATVQAATLARGSGRPASLYLARSKSISSSNPDLAVVPGSVDDEVSRILASKGVDRSHS 913

  Fly   910 IYDNVLASG------------------RSLDRK--------ELSIDVLHSMAARDVQVRLLHEEL 948
            ..::..|.|                  :::||.        |.|...|.:...|....:||||||
  Rat   914 WVNSAYAPGGSKAVLRRVPPYCGADPRQAIDRNSSRASSYLEASSSALPAPQLRHTVQKLLHEEL 978

  Fly   949 ALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTT 1013
            ||.|||:.....:|.:.::||.|:|:||||..||.....|:.|||.|||.:|.||::.||..|..
  Rat   979 ALQWVVSGSAVRELVLQHAWFFFQLMVKSMELHLLLGQRLDTPRKLRFPGRFLDDIAALVASVGL 1043

  Fly  1014 KVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPD---LMNYKI 1075
            :|:.....:.:||:.|||||.||:.|:|||.|||::|.|::.:.|.:.::..|.|:   |:..::
  Rat  1044 EVITRVHKDMELAERLNASLAFFLSDLLSIADRGYIFSLVRAHYKQVATRLQSAPNPAALLTLRM 1108

  Fly  1076 DFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLE----RALHA-DLSQEF 1135
            ||.||:|||||:|.||||    ...::.|.||:||.:|:.||:|..|.:    :.:.. :||..|
  Rat  1109 DFTRILCSHEHYVTLNLP----CCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVISMFELSGPF 1169

  Fly  1136 LQQHFLVGLVLSDLAAVMEVPNPQ----LHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP 1196
            .|||||.||:|::||..:: |..:    ||.|||..:.||:.|||:|:||::...:|:||.||:|
  Rat  1170 RQQHFLSGLLLTELALALD-PEAEGASLLHKKAITAVHNLLCSHDVDSRYTDATVKAKVAELYLP 1233

  Fly  1197 LLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAIS------GSRP--- 1252
            |||:..|.:|:||.......:..::..:.|.....:.....||||.||.||:      |||.
  Rat  1234 LLSLARDTLPRLHGFAEGSGQRSRLASMLDSDTEGEGDIGGTINPSVAMAIAGGPLAPGSRTSIS 1298

  Fly  1253 ---------YSYLNEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQG 1308
                     :....:..::..|||:|::|.||||.||||||.|..:|.||..||:..::.::|..
  Rat  1299 QGPSTKWILFPLCTQAARSGCPLSAESSRTLLVCVLWVLKNAEPALLQRWAADLALPQLGRLLDL 1363

  Fly  1309 VNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRN---S 1370
            :.:||..|||.|:|   ..:|.|:.:|:|  |.|:|.:|||.|.||..||.:::.|.::|:   :
  Rat  1364 LYLCLAAFEYKGKK---AFERINSLTFKK--SLDMKARLEEAILGTIGARQEMVRRSRERSPFGN 1423

  Fly  1371 TEKFRWRKDQMPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA--ANLYHN 1433
            .|..||||....:| |.:|.|.|::.|:|....::|:||||.:||:||.|||||...  :....:
  Rat  1424 QENVRWRKSVTHWR-QTSDRVDKTKDEVEHEALVDGNLATEASLVVLDMLEIIVQTVMLSEARES 1487

  Fly  1434 LLGTVLKVLLHSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPG 1498
            :||.||||:|:||...||.|.||:..|:||||:.|||.|||:::|::||||||.||:||||.:..
  Rat  1488 ILGAVLKVVLYSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRIST 1552

  Fly  1499 IRSQAAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSD 1563
            ||:.|:||||||||||||||:|||||||.|||||||||||:..|||:.|||:|||:|.|||.|..
  Rat  1553 IRTHASASLYLLMRQNFEIGHNFARVKMLVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDLG 1617

  Fly  1564 LQDTSFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKK 1628
            |:|::|.||||||:|||||||:|||||||:|||||||:|||.|||:|||.:||||||||:|||.|
  Rat  1618 LRDSTFAEQVQDLMFNLHMILTDTVKMKEHQEDPEMLMDLMYRIARGYQGSPDLRLTWLQNMASK 1682

  Fly  1629 HRERANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDG 1693
            |.|..||.|||.|.||||:||:|||::||..:|||||.||||.:|.|.|.|||:|||:|||.|:|
  Rat  1683 HAELGNHAEAAQCMVHAAALVAEYLALLEDSRHLPVGCVSFQNVSSNVLEESAISDDILSPDEEG 1747

  Fly  1694 ICLGNHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNR 1758
            .|.|.:||:.||..|||:|:..|.:.|:|||:|||||.||||.||:||::||:.|||||||||.:
  Rat  1748 FCSGKNFTDLGLVGLLEQAAAYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTK 1812

  Fly  1759 I-SQLQG-KRVFGTYFRVGFYGGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHI 1821
            | .|..| :|||||||||||||.:|||||:|||:||||::|||.||..||:.|||||||.|.|.|
  Rat  1813 IMHQSSGWERVFGTYFRVGFYGARFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVEI 1877

  Fly  1822 IKDSNTVDINSLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGEL 1886
            |||||.||...|||.|||||||||||:|:|||::.|.|||:||:.::.|::.||||.:|:|||||
  Rat  1878 IKDSNPVDKLKLDPQKAYIQITYVEPHFDTYELKDRVTYFDRNYGLRAFLFCTPFTPDGRAHGEL 1942

  Fly  1887 NEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQ 1951
            .||.||||:|:|.:.|||:||||.|..|::.||.|:||||||:||||.|||.||.|:|.|.|:||
  Rat  1943 AEQHKRKTLLSTEHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFATEQDPPDAKMLQ 2007

  Fly  1952 MVLQGCIGTTVNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSD 2016
            |||||.:|.||||||:|:|.||||.:.:...: .:|.|||||||::|.|:|.|||:||:.||..|
  Rat  2008 MVLQGSVGPTVNQGPLEVAQVFLSEIPEDPKL-FRHHNKLRLCFKDFCKKCEDALRKNKALIGPD 2071

  Fly  2017 QKDYQRELERNNDRFIERLTPFIT----------LTSVQN 2046
            ||:|.|||||:..|..|.|.|.:|          .||::|
  Rat  2072 QKEYHRELERHYSRLREALQPLLTQRLPQLLAPSSTSLRN 2111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	22/91 (24%)
		C2_Dock-C	589..769	CDD:176078	99/179 (55%)
		DHR-2	1549..2037	CDD:284365	317/489 (65%)
Dock6	XP_038937778.1	DUF3398	48..157	CDD:403173	32/127 (25%)
		C2_Dock-C	547..724	CDD:176078	99/179 (55%)
		DHR2_DOCK	1668..2090	CDD:414667	268/422 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	750	1.000	Domainoid score	I89
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1879	1.000	Inparanoid score	I52
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm45964
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	LDO	PTHR23317
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980