DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zir and Dock4

DIOPT Version :9

Sequence 1:	NP_608489.2	Gene:	Zir / 33165	FlyBaseID:	FBgn0031216	Length:	2064	Species:	Drosophila melanogaster
Sequence 2:	XP_038934052.1	Gene:	Dock4 / 366608	RGDID:	1561724	Length:	1978	Species:	Rattus norvegicus

Alignment Length:	2054	Identity:	378/2054 - (18%)
Similarity:	678/2054 - (33%)	Gaps:	688/2054 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 FEEAFAYKSESCTPSSRQSIASLAS----VSSCTDTLTPRGS-WAS------------------- 199
            |..::.:...:|..:..|....:.:    ::..|.||...|| |..
  Rat    57 FPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGSMWKQLYVRNEGDLFHRLWHIMNE 121

  Fly   200 -FDLRRSVNDPLIPNLLDNVPPE---HI----DQSNEARRQQDRQMALFSLYPESE----AEENI 252
             .||||.|   |:.:|..:...:   ||    |..||       |:.| .|.|..|    ..|:|
  Rat   122 ILDLRRQV---LVGHLTHDRMKDVKRHITARLDWGNE-------QLGL-DLVPRKEYAMVDPEDI 175

  Fly   253 ----------ERRLLAEIPVEHMGHRIQVN-----CLQLRLELEVEPIFASMAIYDAKERQKISE 302
                      .|....:.||:...|.:.|.     |..|..||||  ||   :::|:||.:.|||
  Rat   176 SITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEV--IF---SLFDSKENRPISE 235

  Fly   303 NFYFDMNADSLKRMLSSHVQCADISTQSHSAIFEISYPSN----DLFL---VIRLEKVLQGDINN 360
            .|:..:|.:.|.:        |....:.|.::| :...|:    |:::   :||:.::..|:
  Rat   236 RFFLRLNRNGLPK--------APDKPERHCSLF-VDLGSSELRKDIYITVHIIRIGRMGAGE--- 288

  Fly   361 SVEPYLKEDKDKYREKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGD------------NFES 413
                             |.||...     :||.||....:.:.::..|:            |.||
  Rat   289 -----------------KKNACSV-----QYRRPFGCAVLSIADLLTGETKDDLVLKVYMCNTES 331

  Fly   414 KDAGAAER-----DSFGNACGSSLGTAPSSNSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERK 473
            :.....|.     ::..|..||:.|.|.|...|.     ...:|:||   :.|...:...|:.||
  Rat   332 EWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLH-----GDIEQIRR---EYSSVFSHGVSITRK 388

  Fly   474 EKHRSWSPDDFANVVENFRPITITVPSFFKQEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSI 538
            .        .|::::                                             :||.:
  Rat   389 L--------GFSDII---------------------------------------------MPGEM 400

  Fly   539 KLEISPCVEEAKNALTPELAPINPQSADNVRPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFS 603
                                                               ||.|:::.:...|.
  Rat   401 ---------------------------------------------------RNDLYITVERGEFE 414

  Fly   604 SRAGS-ARNIAVRVQLM--AGETPKDAVNAIYGKSSCPKFSTEAFTAVNYHNKCPSFYDEIKIAL 665
            ....| |||:.|.:.::  .|:..||.::  :|  |....::|..:.|.|||..|.:.:.:|:.:
  Rat   415 KGGKSVARNVEVTMFIVDSNGQPLKDFIS--FG--SGEPLASEYHSFVLYHNNSPRWSELLKLPI 475

  Fly   666 PASIKQHHHLLFTIYHVSCQKKPQDLQPSVETPIGYTWLPLL-EDGKLKFGEFNLP-----VMVE 724
            |....:..|:.|...|.|.::|.:      :...|::::||: |||:      .||     ::|.
  Rat   476 PVDKFRGSHIRFEFRHCSTKEKGE------KKLFGFSFVPLMQEDGR------TLPDGTHELIVH 528

  Fly   725 SPPENYSFIPPNVHL--PGIK--WLDNHRAVFSINVEAVTAIHTLDSFLDRFFLIC--------E 777
            ...||.:......:|  |..|  :|.|       |.:.:.|  |.:||....|| |        :
  Rat   529 KCEENTNLQDTTRYLKFPFSKVIFLGN-------NNQTMKA--TKESFWITSFL-CSTKLTQNGD 583

  Fly   778 YLDTRNIPSHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKLIELLVVTHKVGGQAMSLGS 842
            .||.....:|      ..::..||..::..:...:|:.|...||.|..:|      ...:...||
  Rat   584 MLDLLKWRTH------PDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGIL------DENSQKYGS 636

  Fly   843 TVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYV--HFQCKIPHPFQSKQRLTCSRSTTEDL-QL 904
            .||:.|.   .::::|.|.::..:  :.::.||:  ||...:.:               .|| ::
  Rat   637 KVFDSLV---HIINLLQDSKFHHF--KPVMDTYIESHFAGALAY---------------RDLIKV 681

  Fly   905 SESYTIYDNVLASGRSLDRKELSIDVLHSMAARDVQVRLLHEELALHWVVASGKAADLAMSNSWF 969
            .:.|.  |.:..:    :|:|            .:|..|..:|....::|.|.:...||...
  Rat   682 LKWYV--DRITEA----ERQE------------HIQEVLKAQEYIFKYIVQSRRLFSLATGG--- 725

  Fly   970 LFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTTKVVGYHSNEPKLAQSLNASLG 1034
                                         |..::....:..:...|..:.|.|.|...:|:.|..
  Rat   726 -----------------------------QNEEEFRCCIQELLMSVRFFLSQESKGTGALSQSQA 761

  Fly  1035 FFI-------FDILSIMDRGFVFGLIKTYTKVLISKNASIPDLMNY--KIDFLRIVCSHEHFVAL 1090
            .|:       .::|.:.|       ::....::.....|:|.:|:.  .:..:::.|
  Rat   762 VFLSSFPAVYSELLKLFD-------VREVANLVQDTLGSLPTIMHVDDSLQAIKLQC-------- 811

  Fly  1091 NLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLERALHADLSQEFLQQHFLVGLVLSDLAAVMEV 1155
                             ...|..|...|:..|               ::.|:.:||..|...:
  Rat   812 -----------------IGKTVESQLYTNPDS---------------RYILLPVVLHHLHIHL-- 842

  Fly  1156 PNPQLHGKAIRCIRNLMTSHDL-DARYSETDARARVAALYIPLLSIVMDCIPQLHQHGLEQDRLQ 1219
               |.....|.|.|.|.....| ....||......:..:...||.|::..|.::...........
  Rat   843 ---QEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQASSSAM 904

  Fly  1220 QIGQLEDYQGPHQTITASTINPEVAFAISGSRPYSYLNEQVKNKLPLSSENTRHLLVCFLWVLKN 1284
            :: |.:|..|.......|.:....      .|.|..|         |:|.||:..|..||..:..
  Rat   905 RL-QFQDVTGEFVACLLSLLRQMT------DRHYQQL---------LNSFNTKEELRDFLLQIFT 953

  Fly  1285 LERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEYTGQKNVATLKRTNTQSFRKTGSTDVK----- 1344
            :.| :|.|..|......|.:::.. ||.:.|..|...   |..|....::|      |.|
  Rat   954 VFR-ILIRPEMFPKDWTVMRLVAN-NVIITTVLYLSD---ALRKNFLNENF------DYKIWDSY 1007

  Fly  1345 --------EKLEECIRGTNSARYDLINRRKDRNSTEKF-------------RWRKDQMPYRSQYA 1388
                    .:|  |:      :.::....|.:...||:             .|:
  Rat  1008 FYLAVIFINQL--CL------QLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQ----------- 1053

  Fly  1389 DAVGKSEHELELSHFIEGSLA--TEVALVLLDTLEIIVHAAANLYHNLL-------GTVLKVLLH 1444
               ...||:|   |||...:.  .||.|:....|..::   ..::|:::       |...:|...
  Rat  1054 ---NLGEHKL---HFIPALIGPFLEVTLIPQPDLRNVM---IPIFHDMMDWEQRRSGNFKQVEAK 1109

  Fly  1445 SLSRNQSVLA-------LQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQ 1502
            .:.:..|:::       .:.||.|...|...:|:||...|.:...:..:.|:.....|:..:
  Rat  1110 LIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRLMERL--- 1171

  Fly  1503 AAASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDT 1567
                  |..|...:||....: |:..|:||.:...|.....|..:|      .::...|..|:..
  Rat  1172 ------LDYRDCMKIGEVDGK-KIGCTVSLLNFYKTELNKEEMYIR------YIHKLYDLHLKAQ 1223

  Fly  1568 SFPEQVQDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRER 1632
            :|.|....||....::......::|:...|         :...:|....|.||.::|.
  Rat  1224 NFTEAAYTLLLYDELLEWSDRPLREFLTYP---------MQTEWQRKEHLHLTIIQNF------- 1272

  Fly  1633 ANHTEAAMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLG 1697
                :...|:                                                |:||.|.
  Rat  1273 ----DRGKCW------------------------------------------------ENGIILC 1285

  Fly  1698 NHFTETGLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEA--FNRIS 1760
            .                  ::|..||:.              .|::.|||:  ::.||  :::|.
  Rat  1286 R------------------KIAEQYESY--------------YDYRNLSKM--RMMEASLYDKIM 1316

  Fly  1761 QLQGKRVFGTYFRVGFYGGKFG-DLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKD 1824
            ..|  |:...:|||||||.||. .|..:||:.:.....:|.....|:.|.:     |.:: .::.
  Rat  1317 DQQ--RLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEF-----PHAI-AMQH 1373

  Fly  1825 SNTVDINSLDPDKAYIQITYVEPYFETYEMRHRE-------TYFERNFNIKRFIYATPFTKNGK- 1881
            :|..|......:..|:||..|.|..|:.|:..||       ::::.| :|.:|.|..||.|..|
  Rat  1374 ANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVN-HIWKFRYDRPFHKGTKD 1437

  Fly  1882 AHGELNEQCKRKTILTTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQ---- 1942
            ...|.......:|.|......|.:.....|..|:.:.:.|:|.|||.::.|..:|....:|
  Rat  1438 KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQSR 1502

  Fly  1943 --EPADPKILQMVLQGCIGTTVNQGPMEMASVF------LSNLSDGTTVPTKHQNKLRLCFREFS 1999
              :..:|  |.|.|.|.|...||.|.......|      ||:..||..:.     :||....|.:
  Rat  1503 QMQNINP--LTMCLNGVIDAAVNGGVSRYQEAFFVKDYILSHPEDGEKIA-----RLRELMLEQA 1560

  Fly  2000 KRCADALKKNRNLILSDQKDYQRELERNNDRFIERLTPF 2038
            :.....|..:...:..|.:...::|.   |:|....:.|
  Rat  1561 QILEFGLAVHEKFVPQDMRPLHKKLV---DQFFVMKSSF 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711
		C2_Dock-C	589..769	CDD:176078	47/192 (24%)
		DHR-2	1549..2037	CDD:284365	101/510 (20%)
Dock4	XP_038934052.1	SH3_DOCK4_B	10..65	CDD:212982	1/7 (14%)
		DOCK_N	69..392	CDD:406558	82/388 (21%)
		C2_Dock-B	400..584	CDD:176077	51/260 (20%)
		DHR2_DOCK4	1206..1596	CDD:212578	103/516 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840