Protein Alignment Zir and Dock6

DIOPT Version :9

• Sequence 1: NP_608489.2
• Gene: Zir / 33165
• FlyBaseID: FBgn0031216
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_017168915.1
• Gene: Dock6 / 319899
• MGIID: 1914789
• Length: 2181
• Species: Mus musculus
• Alignment Length: 2159
• Identity: 981/2159 - (45%)
• Similarity: 1349/2159 - (62%)
• Gaps: 198/2159 - (9%)

  Fly     2 SSAQRSFVQKVSKQSAADVRKNVS-----GCHLSKAMDPSLCGSSISPTEPLDYEEFLSQHMNII 61
            :|.:|:|..|:::..||:|||.||     ..|.|:....||........||||:|:.|......:
Mouse     3 ASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRSSSSLGVPLTEVIEPLDFEDVLLSRPPEV 67

  Fly    62 NRDPLKHILDFPQGDVTVKIIPRKIRTVDHVVPNENLSDLPHHVQECVNCYTRPWKVVEYAQRHL 126
            ...||:.:::||..|:.:...||:.||.:..||.:  ..|...|:..|..|:..|.:|....:||
Mouse    68 EPGPLRDLIEFPVDDLELLKQPRECRTTESGVPED--GQLDAQVRAAVEMYSEDWVIVRRRYQHL 130

  Fly   127 SSSCYIRERIDRGTISPSAYQQEFEIDKDFSSFEEAFAYKSESCTP-SSRQSIASLASVSSCTDT 190
            |::           .||...:.:.|..|..:.  :.|    |..|| ..|.....:.....|:.:
Mouse   131 STA-----------YSPITTETQREWQKGLTC--QVF----EQDTPGDERTGPEDVDDPQHCSGS 178

  Fly   191 L--TPRGSWAS--FDLRRSVNDPLIPNLLDNVPPEHIDQSNEARRQQDRQMALFSLYPESEAEEN 251
            .  |||.|.||  |.||....|.|:|.||:...||.:|:.|||.|:|.|...|.:|||..:.:|.
Mouse   179 PEDTPRSSGASGIFSLRNLAADSLLPTLLEQAAPEDVDRRNEALRRQHRAPTLLTLYPAPDEDEA 243

  Fly   252 IERRLLAEIPVEHMGHRIQVNCLQLRLELEVEPIFASMAIYDAKERQKISENFYFDMNADSLKRM 316
            :||....|.|.||.|.||.|.||.|:.|:|:||||.::|:||.:|::|||||||||:|:||:|.:
Mouse   244 VERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGTLALYDVREKKKISENFYFDLNSDSVKGL 308

  Fly   317 LSSHVQCADISTQSHSAIFEISYPSNDLFLVIRLEKVL-QGDINNSVEPY--LKE-----DKDKY 373
            |.:|.....|||.:.||||.::|||.|:|||::||||| ||||:...|||  :||     :|:|.
Mouse   309 LRAHGTHPAISTLARSAIFSVTYPSPDIFLVVKLEKVLQQGDISECCEPYMVMKEADTAKNKEKL 373

  Fly   374 REKVKSNAVDYCERLGKYRMPFAWTGIYLTNVFNGDNFESKDAGAAERDSFGNACGSSLGTAPSS 438
             ||::..|..:|.|||:||||||||.::|.|:.:.......|:....|.::..
Mouse   374 -EKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSRPQDRDSDSEGERRPTWAE------------ 425

  Fly   439 NSLDRKSSTSSFDQLRRKANDMSGTLTRRGSLERKEKHRSWSPDDFANVVENFRPITITVPSFFK 503
                           ||          |||     .:.|.:|.|| |....:|||.|:||.:|||
Mouse   426 ---------------RR----------RRG-----PQDRGYSGDD-ACSFSSFRPATLTVTNFFK 459

  Fly   504 QEADKMKDEDLYKILPELKRPSSVMKKYKCIPGSIKLEISPCVEEAKNALTPELAPINPQSADNV 568
            |||:::.||||:|.|.:::||||::::.:.:...:||:|||..|.....|:|:|..:.|......
Mouse   460 QEAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKLDISPAPENLHFCLSPDLLHVKPYPDPRG 524

  Fly   569 RPVKEILEFPQSAIYNPHYSYRNLLFVSPKELNFSSRAGSARNIAVRVQLMAGETPKDAVNAIYG 633
            ||.|||||||...:|.||..|||||||.|..||||||.||.||:|||:|.||||....|:..|:|
Mouse   525 RPTKEILEFPAREVYAPHSCYRNLLFVYPHSLNFSSRQGSVRNLAVRIQYMAGEDQSQALPVIFG 589

  Fly   634 KSSCPKFSTEAFTAVNYHNKCPSFYDEIKIALPASIKQHHHLLFTIYHVSCQKKPQDLQPSVETP 698
            ||||.:|:.||||.|.||||.|.||:|.|:.|||.:.::|||.||.||||||.:|   ..::|||
Mouse   590 KSSCSEFTREAFTPVVYHNKSPEFYEEFKLRLPACVTENHHLFFTFYHVSCQPRP---GTALETP 651

  Fly   699 IGYTWLPLLEDGKLKFGEFNLPVMVESPPENYSFIPPNVHLPGIKWLDNHRAVFSINVEAVTAIH 763
            :|:||:|||:.|:|:.|.|.|||.|:.||.:||.:.|:|.|||::|:|.|:.|||:.:.||:::|
Mouse   652 VGFTWIPLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVH 716

  Fly   764 TLDSFLDRFFLICEYLDTRNIP-----SHIGENNIETELKKCLLDIEYANREPLVRHLPLVLDKL 823
            ..|..||:||.:...|:....|     :.:.|..:|.||:..|..:..|:.||||....||||||
Mouse   717 PQDPHLDKFFTLVHVLEEGIFPFRLKETVLSEGTMEQELRASLAALRLASPEPLVAFSHLVLDKL 781

  Fly   824 IELLVVTHKVGGQAMSLGSTVFEVLCLVSSLLSILNDDQYDQYGRQSLLSTYVHFQCKIP----- 883
            :.|:|....:.||.::||...||.:..|:||:....:...|..|...||::|||:..::|
Mouse   782 VRLVVRPPIICGQMVNLGRGAFEAMAHVASLVHRNLEAVQDSRGHCPLLASYVHYAFRLPGGDLS 846

  Fly   884 ----HPFQSKQRLTCSR-----------------STTEDLQ------------------LSESYT 909
                .|..:.|..|.:|                 |:..||.                  :..|::
Mouse   847 LPGEAPPATVQAATLARGSGRPASLYLARSKSISSSNPDLAVVPGSVDDEVSRILASKGVDRSHS 911

  Fly   910 IYDNVLASG------------------RSLDRK--------ELSIDVLHSMAARDVQVRLLHEEL 948
            ..::..|.|                  :::||.        |.|...|.:..:|....:||||||
Mouse   912 WVNSAYAPGGSKAVLRRVPPYCGADPRQAIDRNSSRASSYLEASSSALPAPQSRHTVQKLLHEEL 976

  Fly   949 ALHWVVASGKAADLAMSNSWFLFELIVKSMIEHLHCSNTLNGPRKHRFPHQFNDDLSTLVHLVTT 1013
            ||.|||:.....:|.:.::||.|:|:||||..||.....|:.|||.|||.:|.||::.||..|..
Mouse   977 ALQWVVSGSAVRELVLQHAWFFFQLMVKSMELHLLLGQRLDTPRKLRFPGRFLDDIAALVASVGL 1041

  Fly  1014 KVVGYHSNEPKLAQSLNASLGFFIFDILSIMDRGFVFGLIKTYTKVLISKNASIPD---LMNYKI 1075
            :|:.....:.|||:.|||||.||:.|:|||.|||::|.|::.:.|.:.::..|.|:   |:..::
Mouse  1042 EVITRVHKDMKLAERLNASLAFFLSDLLSIADRGYIFSLVRAHYKQVATRLQSAPNPTALLTLRM 1106

  Fly  1076 DFLRIVCSHEHFVALNLPFGTSYTMVTAPCSPTPSTTSSNSQTSCGSLER-----ALHADLSQEF 1135
            ||.||:|||||:|.||||    ...::.|.||:||.:|:.||:|..|.:.     ....:||..|
Mouse  1107 DFTRILCSHEHYVTLNLP----CCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVTSMFELSGPF 1167

  Fly  1136 LQQHFLVGLVLSDLAAVMEVPNPQ----LHGKAIRCIRNLMTSHDLDARYSETDARARVAALYIP 1196
            .|||||.||:|::||..:: |..:    ||.|||..:.:|:.|||:|:||:|...:|:||.||:|
Mouse  1168 RQQHFLSGLLLTELALALD-PEAEGASLLHKKAISAVHSLLCSHDVDSRYAEATVKAKVAELYLP 1231

  Fly  1197 LLSIVMDCIPQLHQHGLEQDRLQQIGQLEDYQGPHQTITASTINPEVAFAISGS--RPYSYL--- 1256
            |||:..|.:||||.......:..::..:.|.....:....|||||.||.||:|.  .|.|..
Mouse  1232 LLSLARDTLPQLHGFAEGSGQRSRLASMLDSDTEGEGDIGSTINPSVAMAIAGGPLAPGSRTSIS 1296

  Fly  1257 ---NEQVKNKLPLSSENTRHLLVCFLWVLKNLERNVLYRWLMDLSPHRVHQMLQGVNVCLKTFEY 1318
               :...::..|||:|::|.||||.||||||.|..:|.||..||:..::.::|..:.:||..|||
Mouse  1297 QGPSTAARSGCPLSAESSRTLLVCVLWVLKNAEPTLLQRWAADLALPQLGRLLDLLYLCLAAFEY 1361

  Fly  1319 TGQKNVATLKRTNTQSFRKTGSTDVKEKLEECIRGTNSARYDLINRRKDRN---STEKFRWRKDQ 1380
            .|:|   ..:|.|:.:|:|  |.|:|.:|||.|.||..||.:::.|.::|:   :.|..||||..
Mouse  1362 KGKK---AFERINSLTFKK--SLDMKARLEEAILGTIGARQEMVRRSRERSPFGNQENVRWRKSA 1421

  Fly  1381 MPYRSQYADAVGKSEHELELSHFIEGSLATEVALVLLDTLEIIVHAA--ANLYHNLLGTVLKVLL 1443
            ..:| |.:|.|.|::.|:|....::|:||||.:||:|||||.||...  :....::|..||||:|
Mouse  1422 THWR-QTSDRVDKTKDEMEHEALVDGNLATEASLVVLDTLETIVQTVMLSEARESILSAVLKVVL 1485

  Fly  1444 HSLSRNQSVLALQNLFASQRALIFKFPNLLFDDETDICADLCLILLKHCGSLLPGIRSQAAASLY 1508
            :||...||.|.||:..|:||||:.|||.|||:::|::||||||.||:||||.:..||..|:||||
Mouse  1486 YSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRMHASASLY 1550

  Fly  1509 LLMRQNFEIGNNFARVKMQVTMSLSSLVGTSSVFSEQSLRRALKTVLVYAESDSDLQDTSFPEQV 1573
            ||||||||||:|||||||.|||||||||||:..|||:.||::|||:|.|||.|..|:|::|.|||
Mouse  1551 LLMRQNFEIGHNFARVKMLVTMSLSSLVGTTQNFSEEHLRKSLKTILTYAEEDIGLRDSTFAEQV 1615

  Fly  1574 QDLLFNLHMILSDTVKMKEYQEDPEMLLDLMNRIAKGYQNNPDLRLTWLENMAKKHRERANHTEA 1638
            |||:|||||||:|||||||:|||||||:|||.|||:|||.:||||||||:|||.||.|..||.||
Mouse  1616 QDLMFNLHMILTDTVKMKEHQEDPEMLMDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEA 1680

  Fly  1639 AMCYVHAASLVSEYLSMLESQKHLPVGAVSFQRISPNTLMESAVSDDVLSPGEDGICLGNHFTET 1703
            |.|.||||:||:|||::||..:|||||.||||.:|.|.|.|||:|||:|||.|:|.|.|.:|||.
Mouse  1681 AQCMVHAAALVAEYLALLEDSRHLPVGCVSFQNVSSNVLEESAISDDILSPDEEGFCSGKNFTEL 1745

  Fly  1704 GLKALLEEASNSFQVAGMYEAMNEVYKILIPICEANRDFQKLSKVHGKLQEAFNRI-SQLQG-KR 1766
            ||..|||:|:..|.:.|:|||:|||||.||||.||:||::||:.|||||||||.:| .|..| :|
Mouse  1746 GLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQSSGWER 1810

  Fly  1767 VFGTYFRVGFYGGKFGDLDQQEFIYKEPTLTKLPEIFSRLQNFYTERFGPDSVHIIKDSNTVDIN 1831
            ||||||||||||.:|||||:|||:||||::|||.||..||:.|||||||.|.|.||||||.||.:
Mouse  1811 VFGTYFRVGFYGTRFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVEIIKDSNPVDKS 1875

  Fly  1832 SLDPDKAYIQITYVEPYFETYEMRHRETYFERNFNIKRFIYATPFTKNGKAHGELNEQCKRKTIL 1896
            .|||.|||||||||||:|:|||::.|.|||:||:.::.|::.||||.:|:|||||.||.||||:|
Mouse  1876 KLDPQKAYIQITYVEPHFDTYELKDRVTYFDRNYGLRAFLFCTPFTPDGRAHGELAEQHKRKTLL 1940

  Fly  1897 TTANHFPYVKTRIMVISRQQIVLEPIEVAIEDIQKKTLELAAATNQEPADPKILQMVLQGCIGTT 1961
            :|.:.|||:||||.|..|::.||.|:||||||:||||.|||.||.|:|.|.|:|||||||.:|.|
Mouse  1941 STEHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFATEQDPPDAKMLQMVLQGSVGPT 2005

  Fly  1962 VNQGPMEMASVFLSNLSDGTTVPTKHQNKLRLCFREFSKRCADALKKNRNLILSDQKDYQRELER 2026
            |||||:|:|.||||.:.:...: .:|.|||||||::|.|:|.|||:||:.||..|||:|.|||||
Mouse  2006 VNQGPLEVAQVFLSEIPEDPKL-FRHHNKLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELER 2069

  Fly  2027 NNDRFIERLTPFIT 2040
            :..|..|.|.|.:|
Mouse  2070 HYSRLREALQPLLT 2083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zir	NP_608489.2	DUF3398	59..151	CDD:288711	22/91 (24%)
		C2_Dock-C	589..769	CDD:176078	99/179 (55%)
		DHR-2	1549..2037	CDD:284365	317/489 (65%)
Dock6	XP_017168915.1	DUF3398	48..157	CDD:371776	32/127 (25%)
		C2_Dock-C	545..722	CDD:176078	99/179 (55%)
		DHR2_DOCK	1656..2078	CDD:384404	269/422 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	742	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_KOG1997
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1863	1.000	Inparanoid score	I60
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55633
OrthoDB	1	1.010	-	-		D14993at33208
OrthoFinder	1	1.000	-	-		FOG0000340
OrthoInspector	1	1.000	-	-		otm43876
orthoMCL	1	0.900	-	-		OOG6_100358
Panther	1	1.100	-	-	LDO	PTHR23317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840